Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Adrian P. Mountford"'
Autor:
David E Sanin, Adrian P Mountford
Publikováno v:
Parasites & Vectors, Vol 8, Iss 1, Pp 1-12 (2015)
Abstract Background Schistosoma mansoni cercariae penetrate the skin by releasing excretory/secretory (E/S) products known as 0-3hRP, which are associated with immune modulation through Toll like receptor (TLR) signalling. Furthermore, these secretio
Externí odkaz:
https://doaj.org/article/475c4f078098456b9d4c681e0a5dd7a3
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004911 (2016)
In a murine model of repeated exposure of the skin to infective Schistosoma mansoni cercariae, events leading to the priming of CD4 cells in the skin draining lymph nodes were examined. The dermal exudate cell (DEC) population recovered from repeated
Externí odkaz:
https://doaj.org/article/3d59119ecf844210b0c3cd3de0d02111
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004841 (2015)
The skin provides an important first line of defence and immunological barrier to invasive pathogens, but immune responses must also be regulated to maintain barrier function and ensure tolerance of skin surface commensal organisms. In schistosomiasi
Externí odkaz:
https://doaj.org/article/2402fa00dc86412bb47969fcc9c811df
Autor:
Joseph D Turner, Claire D Bourke, Lynn Meurs, Moustapha Mbow, Tandakha Ndiaye Dièye, Souleymane Mboup, Katja Polman, Adrian P Mountford
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2817 (2014)
Circulating monocyte sub-sets have recently emerged as mediators of divergent immune functions during infectious disease but their role in helminth infection has not been investigated. In this study we evaluated whether 'classical' (CD14brightCD16-),
Externí odkaz:
https://doaj.org/article/374927509f974c839f893f86c5eaaeda
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1003063 (2012)
Schistosomes are blood-dwelling parasitic helminths which produce eggs in order to facilitate transmission. Intestinal schistosomes lay eggs in the mesenteries, however, it is unclear how their eggs escape the vasculature to exit the host. Using a mu
Externí odkaz:
https://doaj.org/article/bfa5026cad6e4dea998d9982b4a048af
Autor:
Joseph D Turner, Gavin R Jenkins, Karen G Hogg, Sarah A Aynsley, Ross A Paveley, Peter C Cook, Mark C Coles, Adrian P Mountford
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 8, p e1269 (2011)
Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity. However, although CD4+CD25+FoxP3+ regu
Externí odkaz:
https://doaj.org/article/c358775b61f74ea0803b070abac259ab
Autor:
Peter C Cook, Sarah A Aynsley, Joseph D Turner, Gavin R Jenkins, Nico Van Rooijen, Mosiuoa Leeto, Frank Brombacher, Adrian P Mountford
Publikováno v:
PLoS Pathogens, Vol 7, Iss 3, p e1001323 (2011)
Infection of the mammalian host by schistosome larvae occurs via the skin, although nothing is known about the development of immune responses to multiple exposures of schistosome larvae, and/or their excretory/secretory (E/S) products. Here, we show
Externí odkaz:
https://doaj.org/article/029cab324ffe43299c6dab7fc3ada1a1
Autor:
Lynn Meurs, Lucja Labuda, Abena Serwaa Amoah, Moustapha Mbow, Ulysse Ateba Ngoa, Daniel Adjei Boakye, Souleymane Mboup, Tandakha Ndiaye Dièye, Adrian P Mountford, Joseph D Turner, Peter Gottfried Kremsner, Katja Polman, Maria Yazdanbakhsh, Ayola Akim Adegnika
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24393 (2011)
BackgroundSchistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shapes the adaptive response, has not been e
Externí odkaz:
https://doaj.org/article/216218e08e8f4e8fb30075f04f340b4d
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 10, p e528 (2009)
Infection of the mammalian host by the parasitic helminth Schistosoma mansoni is accompanied by the release of excretory/secretory molecules (ES) from cercariae which aid penetration of the skin. These ES molecules are potent stimulants of innate imm
Externí odkaz:
https://doaj.org/article/4488ce64808d442c84d4f48791b3dd95
Publikováno v:
The Journal of Immunology Author Choice
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections, macrophages are an important source of IL-10; however, the molecular mechanism underpinning production of IL-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5f74c252786db8f068b56e25147fd7
https://doi.org/10.4049/jimmunol.1500146
https://doi.org/10.4049/jimmunol.1500146