Výsledky vyhledávání - "Adrian P. Ireland"

Clinical Significance of p53 Mutations in Adenocarcinoma of the Esophagus and Cardia

Autor: Jeffrey H. Peters, Darryl Shibata, Para Chandrasoma, Adrian P. Ireland, Tom R. DeMeester, Reginald V. Lord

Publikováno v: Annals of Surgery. 231:179-187

p53 gene abnormalities are common in human tumors, 1 and involvement of p53, by mutation, 2–10 altered mRNA expression, 11,12 allelic loss, 8,13–18 or protein overexpression, is found in a majority of esophageal adenocarcinomas. Although numerous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcdedc2abbb3dc16a2fdbba3190c126
https://doi.org/10.1097/00000658-200002000-00005

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Duodenoesophageal reflux induces esophageal adenocarcinoma without exogenous carcinogen

Autor: Martin Fein, Adrian P. Ireland, Jeffrey A. Hagen, Manfred P. Ritter, Jeffrey H. Peters, Stefan Öberg, Cedric G. Bremner, Tom R. DeMeester, Para Chandrasoma

Publikováno v: Journal of Gastrointestinal Surgery. 2:260-268

In the rat model, esophageal adenocarcinoma reproducibly develops following surgically induced duodenal reflux into the esophagus and administration of nitrosamine. In addition, decreasing gastric acid via partial or total gastrectomy increases the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049c9af26dae9105e7e164d461427c2c
https://doi.org/10.1016/s1091-255x(98)80021-8

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Inflammation and Specialized Intestinal Metaplasia of Cardiac Mucosa Is a Manifestation of Gastroesophageal Reflux Disease

Autor: Adrian P. Ireland, Para Chandrasoma, Peter F. Crookes, Manfred P. Ritter, Tom R. DeMeester, Jeffrey H. Peters, Rodney J. Mason, Cedric G. Bremner, Jeffrey A. Hagen, Stefan Öberg

Publikováno v: Annals of Surgery. 226:522-532

OBJECTIVE: The purpose of the study was to test the hypothesis that cardiac mucosa, carditis, and specialized intestinal metaplasia at an endoscopically normal-appearing cardia are manifestations of gastroesophageal reflux disease. SUMMARY BACKGROUND

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d0ad11b2c36488321e008301100039
https://doi.org/10.1097/00000658-199710000-00013

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Duodenogastric reflux potentiates the injurious effects of gastroesophageal reflux

Autor: Manfred P. Ritter, Martin Fein, Tom R. DeMeester, Jeffrey H. Peters, Adrian P. Ireland, Jeffrey A. Hagen, Cedric G. Bremmer

Publikováno v: Journal of Gastrointestinal Surgery. 1:27-33

Experimental studies have shown that the severity of esophageal mucosal injury in gastroesophageal reflux disease is related to the reflux of both gastric and duodenal juice. The purpose of this study was to determine whether duodenal juice potentiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075085c56fb23389387f4319142345c0
https://doi.org/10.1007/s11605-006-0006-x

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Gastric Juice Protects Against the Development of Esophageal Adenocarcinoma in the Rat

Autor: Sidney S. Mirvish, Thomas C. Smyrk, Tom R. Demeester, Geoffrey W.B. Clark, Adrian P. Ireland, Jeffrey H. Peters, Thomas E. Adrian

Publikováno v: Annals of Surgery. 224:358-371

Objective The authors investigate the effects of gastric juice on tumorigenesis in a rat model of esophageal adenocarcinoma. Summary Background Data In rats treated with the carcinogen methyl-n-amyl nitrosamine, squamous cancer of the esophagus devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591007b9811b4a9fa83719cd575a3a12
https://doi.org/10.1097/00000658-199609000-00012

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Dysplasia in Barrett’s Esophagus: Diagnosis, Surveillance and Treatment

Autor: Adrian P. Ireland, Tom R. DeMeester, Geoffrey W.B. Clark

Publikováno v: Digestive Diseases. 14:213-227

Barrett's esophagus is a premalignant metaplastic change in the lining of the distal esophagus. It represents a peculiar form of healing which occurs in response to chronic gastroesophageal reflux disease. The condition should be considered in all pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097f3a54eb342613932a4b9c732e10db
https://doi.org/10.1159/000171554

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Carcinoembryonic antigen measurements in the management of esophageal cancer: An indicator of subclinical recurrence

Autor: Jeffrey A. Hagen, Jeffrey H. Peters, Jean-Marie Collard, Tom R. DeMeester, Geoffrey W.B. Clark, Adrian P. Ireland

Publikováno v: The American Journal of Surgery. 170:597-601

Background : Detection of subclinical recurence after surgical resection of esophageal cancer would allow earlier treatment of recurrent disease and potentially offer a better outcome for rescue therapy. Methods : The utility of serum carcinoembryoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55606adab83ee45c2a92df7e0073bfa8
https://doi.org/10.1016/s0002-9610(99)80023-3

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A tailored approach to antireflux surgery

Autor: Tom R. DeMeester, Cedric G. Bremner, Adrian P. Ireland, Jeffrey H. Peters, Werner K. H. Kauer, Johannes Heimbucher

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 110:141-147

Tailored surgical antireflux procedures were done in 104 patients during a 7-year period. Presenting symptoms included heartburn in 95 patients (91%), regurgitation in 83 patients (80%), and dysphagia in 61 patients (60%). Evaluation before operation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18da2bcbc2bacb7f313425d39df5bca1
https://doi.org/10.1016/s0022-5223(05)80019-4

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Does duodenal juice reflux into the esophagus of patients with complicated GERD? evaluation of a fiberoptic sensor for bilirubin

Autor: Adrian P. Ireland, Tom R. DeMeester, Geoffrey W.B. Clark, Patricio Burdiles, Werner K. H. Kauer, Cedric G. Bremner, Jeffrey H. Peters

Publikováno v: The American Journal of Surgery. 169:98-104

Background It is controversial whether duodenal juice can damage esophageal mucosa in patients with gastroesophageal reflux disease (GERD). The issue remains unresolved partly because of difficulties in detecting the presence of duodenal juice in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a293c36f7864d44e07ed21c1080aa45
https://doi.org/10.1016/s0002-9610(99)80116-0

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Outcome of adenocarcinoma arising in Barrett's esophagus in endoscopically surveyed and nonsurveyed patients

Autor: Para Chandrasoma, Jeffrey H. Peters, Adrian P. Ireland, Tom R. DeMeester, Geoffrey W.B. Clark, Thomas C. Smyrk

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 108:813-822

The value of endoscopic surveillance of Barrett's esophagus and the appropriate management of high-grade dysplasia remain unclear. Seventeen patients who were referred from endoscopic surveillance programs for management of high-grade dysplasia or ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3779ea97691aacce2f0c20982c6b7a74
https://doi.org/10.1016/s0022-5223(94)70178-4

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