Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Adrian P. Ireland"'
Autor:
Jeffrey H. Peters, Darryl Shibata, Para Chandrasoma, Adrian P. Ireland, Tom R. DeMeester, Reginald V. Lord
Publikováno v:
Annals of Surgery. 231:179-187
p53 gene abnormalities are common in human tumors, 1 and involvement of p53, by mutation, 2–10 altered mRNA expression, 11,12 allelic loss, 8,13–18 or protein overexpression, is found in a majority of esophageal adenocarcinomas. Although numerous
Autor:
Martin Fein, Adrian P. Ireland, Jeffrey A. Hagen, Manfred P. Ritter, Jeffrey H. Peters, Stefan Öberg, Cedric G. Bremner, Tom R. DeMeester, Para Chandrasoma
Publikováno v:
Journal of Gastrointestinal Surgery. 2:260-268
In the rat model, esophageal adenocarcinoma reproducibly develops following surgically induced duodenal reflux into the esophagus and administration of nitrosamine. In addition, decreasing gastric acid via partial or total gastrectomy increases the p
Autor:
Adrian P. Ireland, Para Chandrasoma, Peter F. Crookes, Manfred P. Ritter, Tom R. DeMeester, Jeffrey H. Peters, Rodney J. Mason, Cedric G. Bremner, Jeffrey A. Hagen, Stefan Öberg
Publikováno v:
Annals of Surgery. 226:522-532
OBJECTIVE: The purpose of the study was to test the hypothesis that cardiac mucosa, carditis, and specialized intestinal metaplasia at an endoscopically normal-appearing cardia are manifestations of gastroesophageal reflux disease. SUMMARY BACKGROUND
Autor:
Manfred P. Ritter, Martin Fein, Tom R. DeMeester, Jeffrey H. Peters, Adrian P. Ireland, Jeffrey A. Hagen, Cedric G. Bremmer
Publikováno v:
Journal of Gastrointestinal Surgery. 1:27-33
Experimental studies have shown that the severity of esophageal mucosal injury in gastroesophageal reflux disease is related to the reflux of both gastric and duodenal juice. The purpose of this study was to determine whether duodenal juice potentiat
Autor:
Sidney S. Mirvish, Thomas C. Smyrk, Tom R. Demeester, Geoffrey W.B. Clark, Adrian P. Ireland, Jeffrey H. Peters, Thomas E. Adrian
Publikováno v:
Annals of Surgery. 224:358-371
Objective The authors investigate the effects of gastric juice on tumorigenesis in a rat model of esophageal adenocarcinoma. Summary Background Data In rats treated with the carcinogen methyl-n-amyl nitrosamine, squamous cancer of the esophagus devel
Publikováno v:
Digestive Diseases. 14:213-227
Barrett's esophagus is a premalignant metaplastic change in the lining of the distal esophagus. It represents a peculiar form of healing which occurs in response to chronic gastroesophageal reflux disease. The condition should be considered in all pa
Autor:
Jeffrey A. Hagen, Jeffrey H. Peters, Jean-Marie Collard, Tom R. DeMeester, Geoffrey W.B. Clark, Adrian P. Ireland
Publikováno v:
The American Journal of Surgery. 170:597-601
Background : Detection of subclinical recurence after surgical resection of esophageal cancer would allow earlier treatment of recurrent disease and potentially offer a better outcome for rescue therapy. Methods : The utility of serum carcinoembryoni
Autor:
Tom R. DeMeester, Cedric G. Bremner, Adrian P. Ireland, Jeffrey H. Peters, Werner K. H. Kauer, Johannes Heimbucher
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 110:141-147
Tailored surgical antireflux procedures were done in 104 patients during a 7-year period. Presenting symptoms included heartburn in 95 patients (91%), regurgitation in 83 patients (80%), and dysphagia in 61 patients (60%). Evaluation before operation
Autor:
Adrian P. Ireland, Tom R. DeMeester, Geoffrey W.B. Clark, Patricio Burdiles, Werner K. H. Kauer, Cedric G. Bremner, Jeffrey H. Peters
Publikováno v:
The American Journal of Surgery. 169:98-104
Background It is controversial whether duodenal juice can damage esophageal mucosa in patients with gastroesophageal reflux disease (GERD). The issue remains unresolved partly because of difficulties in detecting the presence of duodenal juice in the
Autor:
Para Chandrasoma, Jeffrey H. Peters, Adrian P. Ireland, Tom R. DeMeester, Geoffrey W.B. Clark, Thomas C. Smyrk
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 108:813-822
The value of endoscopic surveillance of Barrett's esophagus and the appropriate management of high-grade dysplasia remain unclear. Seventeen patients who were referred from endoscopic surveillance programs for management of high-grade dysplasia or ad