GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop

Autor: Brian K. Fiske, Simon R.W. Stott, Mart Saarma, Camille Carroll, David Eidelberg, Roger A. Barker, Richard K. Wyse, Patrik Brundin, Amber D. Van Laar, Jamie L. Eberling, David T Dexter, Henri J. Huttunen, Merja H. Voutilainen, Adrian P. Kells, Jeffrey H. Kordower, Eros Bresolin, Alasdair Coles, Leah Mursaleen, Don M. Gash, Karl Kieburtz, Alan L Whone, Howard J. Federoff, A. Jon Stoessl, Sigrid Booms, Lyndsey Isaacs, Massimo S. Fiandaca, Anthony E. Lang, Codrin Lungu, Krystof S. Bankiewicz, Helen Matthews, Anders Björklund

Publikováno v: Journal of Parkinson's disease, vol 10, iss 3
Barker, R A, Bjorklund, A, Gash, D M, Whone, A, Van Laar, A, Kordower, J H, Bankiewicz, K, Kieburtz, K, Saarma, M, Booms, S, Huttunen, H J, Kells, A, Fiandaca, M S, Stoessl, A J, Eidelberg, D, Federoff, H, Voutilainen, M, Dexter, D T, Eberling, J, Brundin, P, Isaacs, L, Mursaleen, L, Bresolin, E, Carroll, C, Coles, A, Fiske, B, Matthews, H, Lungu, C, Wyse, R K, Stott, S & Lang, A E 2020, ' GDNF and Parkinson's Disease : Where Next? A Summary from a Recent Workshop ', Journal of Parkinson's Disease, vol. 10, no. 3, pp. 875-891 . https://doi.org/10.3233/JPD-202004
Journal of Parkinson's Disease

The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using glial cell line-derived neurotrophic factor (GDNF). This neurotrophic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88877f6c9a7279991a0d0736af61ec6
https://doi.org/10.3233/jpd-202004

Safety and tolerability of MRI-guided infusion of AAV2-hAADC into the mid-brain of nonhuman primate

Autor: Waldy San Sebastian, Adrian P Kells, John Bringas, Lluis Samaranch, Piotr Hadaczek, Agnieszka Ciesielska, Michael J Macayan, Phillip J Pivirotto, John Forsayeth, Sheryl Osborne, J Fraser Wright, Foad Green, Gregory Heller, Krystof S Bankiewicz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)

Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare, autosomal-recessive neurological disorder caused by mutations in the DDC gene that leads to an inability to synthesize catecholamines and serotonin. As a result, patients suffer comprom

Externí odkaz: https://doaj.org/article/6808879212064f8090e19ab0d9b2d62a

Widespread optogenetic expression in macaque cortex obtained with MR-guided, convection enhanced delivery (CED) of AAV vector to the thalamus

Autor: John Bringas, Viktor Kharazia, Adrian P. Kells, Krystof S. Bankiewicz, Nan Tian, Ji-Wei He, Azadeh Yazdan-Shahmorad, Lluis Samaranch, Philip N. Sabes

Publikováno v: Journal of Neuroscience Methods. 293:347-358

Background In non-human primate (NHP) optogenetics, infecting large cortical areas with viral vectors is often a difficult and time-consuming task. Previous work has shown that parenchymal delivery of adeno-associated virus (AAV) in the thalamus by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf471353da5099cd70ba9aa2550950e
https://doi.org/10.1016/j.jneumeth.2017.10.009

Development of a novel frameless skull-mounted ball-joint guide array for use in image-guided neurosurgery

Autor: Krystof S. Bankiewicz, John Bringas, Jerusha Naidoo, Adrian P. Kells, Massimo S. Fiandaca, Lluis Samaranch, Amin Mahmoodi, Vivek Sudhakar

Publikováno v: Journal of neurosurgery. 132(2)

OBJECTIVESuccessful convection-enhanced delivery of therapeutic agents to subcortical brain structures requires accurate cannula placement. Stereotactic guiding devices have been developed to accurately target brain nuclei. However, technologies rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf9514a4cbf3bc1f0e4cbc25e53acad
https://pubmed.ncbi.nlm.nih.gov/30771782

Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain

Autor: Sarah J. Nelson, Lucas Carvajal, Peder E. Z. Larson, Philip Pivirotto, James Tropp, Robert Bok, Fraser Robb, Krystof S. Bankiewicz, Adrian P. Kells, Ilwoo Park, Daniel B. Vigneron, Galen D. Reed, John Bringas

Publikováno v: Magnetic Resonance in Medicine. 71:19-25

Purpose To investigate hyperpolarized 13C metabolic imaging methods in the primate brain that can be translated into future clinical trials for patients with brain cancer.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb8bd178aea6a69fe707a95dde345945
https://doi.org/10.1002/mrm.25003