Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Adrian Mallen"'
Autor:
Miguel Hueso, Adrian Mallen, Elia Ripoll, Laura de Ramon, Nuria Bolaños, Christian Valera, Jordi Guiteras, Javier Raya, Estanislao Navarro, Josep Maria Grinyo, Josep Maria Cruzado, Josep Maria Aran, JUAN TORRAS
Publikováno v:
Bio-Protocol, Vol 11, Iss 10 (2021)
The co-stimulatory molecule CD40 and its ligand CD40L play a key role in the regulation of immunological processes and are involved in the pathophysiology of autoimmune and inflammatory diseases. Inhibition of the CD40-CD40L axis is a promising thera
Externí odkaz:
https://doaj.org/article/5dc9ec3fd6f54dd6ba36d0738368d31d
Autor:
Adrián Mallén, Ronny Rodriguez-Urquia, Rafael Alvarez, Eduard Dorca-Duch, Estanis Navarro, Miguel Hueso
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13442 (2023)
This study analyzes sex-based differences in renal structure and the response to the Angiotensin-Converting Enzyme (ACE) inhibitor enalapril in a mouse model of atherosclerosis. Eight weeks old ApoE−/− mice received enalapril (5 mg/kg/day, subcut
Externí odkaz:
https://doaj.org/article/c16d0764542e42df9ea9003603b1f44b
Publikováno v:
Clinical and Translational Medicine, Vol 9, Iss 1, Pp 1-18 (2020)
Abstract Completion of the human genome sequencing project highlighted the richness of the cellular RNA world, and opened the door to the discovery of a plethora of short and long non-coding RNAs (the dark transcriptome) with regulatory or structural
Externí odkaz:
https://doaj.org/article/4d7b192f492648f2bb786d9c9a084523
Autor:
Miguel Hueso, Raquel Griñán, Adrián Mallen, Estanislao Navarro, Elvira Purqueras, Montse Gomá, Fabrizio Sbraga, Arnau Blasco-Lucas, Giovanna Revilla, David Santos, Marina Canyelles, Josep Julve, Joan Carles Escolà-Gil, Noemi Rotllan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112596- (2022)
Objective: To determine whether miR-125b regulates cholesterol efflux in vivo and in vitro through the regulation of scavenger receptor type B1 (SR-B1). Approach and results: We demonstrated that miR-125b is up-regulated in the human aortas of patien
Externí odkaz:
https://doaj.org/article/930b61a38733447f907ef639a1a6b40e
Autor:
Miguel Hueso, Angela Casas, Adrian Mallén, Laura de Ramón, Nuria Bolaños, Cristian Varela, Josep M. Cruzado, Joan Torras, Estanislao Navarro
Publikováno v:
Journal of Inflammation, Vol 16, Iss 1, Pp 1-9 (2019)
Abstract Background Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. Purpose of the study We have previously reported that
Externí odkaz:
https://doaj.org/article/a7604216db334c4e9b04468feb1b2421
Autor:
Miguel Hueso, Adrián Mallén, Marc Suñé-Pou, Josep M. Aran, Josep M. Suñé-Negre, Estanislao Navarro
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11596 (2021)
Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding “on-targ
Externí odkaz:
https://doaj.org/article/97e85df3e1ae4eb990b296c78749e545
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1560 (2021)
This paper concerns 3′-untranslated regions (3′UTRs) of mRNAs, which are non-coding regulatory platforms that control stability, fate and the correct spatiotemporal translation of mRNAs. Many mRNAs have polymorphic 3′UTR regions. Controlling 3
Externí odkaz:
https://doaj.org/article/b5968e3f5f3844f29f2314473f5d8c34
Autor:
Angela Casas, Adrián Mallén, Arnau Blasco-Lucas, Fabrizio Sbraga, Jordi Guiteras, Núria Bolaños, Esther Castaño, Joan Torras, Josep M. Cruzado, Estanislao Navarro, Miguel Hueso
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9689 (2020)
Cardiovascular mortality increases with decreasing renal function although the cause is yet unknown. Here, we have investigated whether low chronic inflammation in chronic kidney diseases (CKD) could contribute to increased risk for coronary artery d
Externí odkaz:
https://doaj.org/article/df6e76c3f4714c8fb2a6c271eb9d90df
Autor:
Miguel Hueso, Adrián Mallén, Ángela Casas, Jordi Guiteras, Fabrizio Sbraga, Arnau Blasco-Lucas, Núria Lloberas, Joan Torras, Josep M Cruzado, Estanislao Navarro
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1943 (2020)
Our interest in the mechanisms of atherosclerosis progression (ATHp) has led to the recent identification of 13 miRNAs and 1285 mRNAs whose expression was altered during ATHp. Here, we deepen the functional relationship among these 13 miRNAs and gene
Externí odkaz:
https://doaj.org/article/7668d6aa116d4d47afa01f247261c30d