Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Adrian M. Timmers"'
Autor:
Guo-jie Ye, Chunjuan Song, Judith A Newmark, Artur V. Cideciyan, Paulette M. Robinson, William A. Beltran, Adrian M. Timmers, David R. Knop, Jeffrey D. Chulay, Valerie L. Dufour, Mark S. Shearman, Malgorzata Swider, Samuel G. Jacobson, Gustavo D. Aguirre
Publikováno v:
Human Gene Therapy. 31:743-755
Recombinant adeno-associated viral (rAAV) vector-mediated gene therapy is being developed to treat X-linked retinitis pigmentosa (XLRP) in patients with mutations in the retinitis pigmentosa GTPase...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d5934e3222dc6e28d819ad2a74f3319
https://doi.org/10.1089/hum.2019.337
https://doi.org/10.1089/hum.2019.337
Autor:
Savitri Mandapati, Chunjuan Song, Alok K. Sharma, Mailin Van Hoosear, William W. Hauswirth, Guo-jie Ye, Jeffrey D. Chulay, Adrian M. Timmers, Cayrn Plummer, Ping Zhu, David R. Knop, Kari B. Green, Paulette M. Robinson, Peter Sonnentag, Wen-Tao Deng, Mark S. Shearman, Thomas J. Conlon, Kirsten E. Coleman
Publikováno v:
Human Gene Therapy Clinical Development. 29:188-197
Applied Genetic Technologies Corporation (AGTC) is developing a recombinant adeno-associated virus (rAAV) vector AGTC-501, also designated AAV2tYF-GRK1-RPGRco, to treat retinitis pigmentosa (RP) in patients with mutations in the retinitis pigmentosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b489755bd2d1a5d95261f2a3fbdae5a
https://doi.org/10.1089/humc.2018.168
https://doi.org/10.1089/humc.2018.168
Autor:
Chunjuan, Song, Valérie L, Dufour, Artur V, Cideciyan, Guo-Jie, Ye, Malgorzata, Swider, Judith A, Newmark, Adrian M, Timmers, Paulette M, Robinson, David R, Knop, Jeffrey D, Chulay, Samuel G, Jacobson, Gustavo D, Aguirre, William A, Beltran, Mark S, Shearman
Publikováno v:
Hum Gene Ther
Recombinant adeno-associated viral (rAAV) vector-mediated gene therapy is being developed to treat X-linked retinitis pigmentosa (XLRP) in patients with mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. In preparation for a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2be0c995000c54107b1d9fc3480798d
https://pubmed.ncbi.nlm.nih.gov/32414297
https://pubmed.ncbi.nlm.nih.gov/32414297
Autor:
Chunjuan Song, Mark S. Shearman, Guo-jie Ye, Artur V. Cideciyan, Paulette M. Robinson, Gui-Shuang Ying, Gustavo D. Aguirre, Valerie L. Dufour, Malgorzata Swider, Adrian M. Timmers, William A. Beltran, Nicole M. Weinstein, Perry L. Habecker, Wei Pan, David R. Knop, Samuel G. Jacobson, Jeffrey D. Chulay, Amy C. Durham
Publikováno v:
Hum Gene Ther
Applied Genetic Technologies Corporation (AGTC) is developing a recombinant adeno-associated virus (rAAV) vector AGTC-501, also designated rAAV2tYF-GRK1-hRPGRco, to treat X-linked retinitis pigmentosa (XLRP) in patients with mutations in the retiniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17baaee2c96a459978db598f5984fe3
https://pubmed.ncbi.nlm.nih.gov/32589471
https://pubmed.ncbi.nlm.nih.gov/32589471
Autor:
Chantelle Gaskin, Tanaz Farivar, Heikki T Turunen, David R. Knop, Chunjuan Song, Judith A Newmark, Mark S. Shearman, Steven Pennock, Guo-jie Ye, Adrian M. Timmers, Jilin Liu
Publikováno v:
Human gene therapy. 31(1-2)
Both subretinal dosing and intravitreal (IVT) dosing of adeno-associated virus (AAV) in higher species induce mild and transient inflammatory responses that increase with dose. Foreign protein and foreign DNA are known inducers of inflammation, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eafab03a357ba8a3a65e2b0391a695d
https://pubmed.ncbi.nlm.nih.gov/31544533
https://pubmed.ncbi.nlm.nih.gov/31544533
Autor:
Mark S. Sands, Judith Mosinger Ogilvie, William W. Hauswirth, Anne K. Hennig, Kevin K. Ohlemiller, Adrian M. Timmers
Publikováno v:
Molecular Therapy. 10(1):106-116
The beta-glucuronidase-deficient mucopolysaccharidosis type VII (MPS VII) mouse accumulates partially degraded glycosaminoglycans in many cell types, including retinal pigmented epithelial (RPE) cells in the eye. This lysosomal storage in RPE cells l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f615688a1e1926b625742eab12ded9
Autor:
Adrian M. Timmers, Judith D. Ochrietor, Takashi Muramatsu, Tatiana P. Moroz, Paul J. Linser, Michael F. Clamp
Publikováno v:
Vision Research. 42:447-453
5A11/Basigin is an immunoglobulin-like glycoprotein expressed on the surface of Müller cells, the apical and basal surfaces of the retinal pigmented epithelium, and photoreceptor cell bodies and their inner segments. Disruption of the 5A11/Basigin g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25609684fdf6c43385f2b52048f8b9d
https://doi.org/10.1016/s0042-6989(01)00236-x
https://doi.org/10.1016/s0042-6989(01)00236-x
Autor:
Seok Hong Min, Yumiko Umino, Drew Everhart, Jijing Pang, William W. Hauswirth, Robert B. Barlow, Qiuhong Li, Adrian M. Timmers, Bo Chang, Norman L. Hawes, John J. Alexander
Publikováno v:
Nature Medicine. 13:685-687
Loss of cone function in the central retina is a pivotal event in the development of severe vision impairment for many prevalent blinding diseases. Complete achromatopsia is a genetic defect resulting in cone vision loss in 1 in 30,000 individuals. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f9ec3bc73bf799857d8f8e340c8958
https://doi.org/10.1038/nm1596
https://doi.org/10.1038/nm1596
Autor:
J.H. McDowell, Krzysztof Palczewski, W. C. Smith, H. Van Der Wel, Robert J. Ulshafer, Adrian M. Timmers, Grazyna Adamus, Paul A. Hargrave
Publikováno v:
Experimental Eye Research. 61:569-578
We sequenced selected peptides of alligator rhodopsin that accounted for about half of the total protein. These sequences were confirmed when the total primary structure of alligator rhodopsin was deduced from the cDNA sequence. Differences in the am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e49a30f1dbf7000dd9db651c4b677f
https://doi.org/10.1016/s0014-4835(05)80051-x
https://doi.org/10.1016/s0014-4835(05)80051-x
Autor:
Adrian M. Timmers, Charles A. Thornton, Karen A. Johnstone, Maurice S. Swanson, Douglas W. Esson, William W. Hauswirth, Codrin Lungu, Ami Mankodi, Rahul N. Kanadia
Publikováno v:
Science. 302:1978-1980
The neuromuscular disease myotonic dystrophy (DM) is caused by microsatellite repeat expansions at two different genomic loci. Mutant DM transcripts are retained in the nucleus together with the muscleblind (Mbnl) proteins, and these abnormal RNAs so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1156cc1fde753f16f1ac8a67353704d5
https://doi.org/10.1126/science.1088583
https://doi.org/10.1126/science.1088583