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pro vyhledávání: '"Adrian M. Eiden"'
Autor:
Wei Shi, Valery Bliskovsky, Adrian M. Eiden, Daniel Connors, Wendy Dubois, Edward S. Ramsay, Beverly A. Mock, Shuling Zhang, Matthew Steinsaltz
Publikováno v:
Journal of Biological Chemistry. 294:16756-16764
Mechanistic target of rapamycin (MTOR) is a highly conserved serine/threonine kinase that critically regulates cell growth, proliferation, differentiation, and survival. Previously, we have implicated Mtor as a plasmacytoma-resistance locus, Pctr2, i
Publikováno v:
Clinical Cancer Research. 22:277-283
As one of the earliest examples of “chemical biology,” the Mechanistic Target of Rapamycin (mTOR) protein and its chemical inhibitors have been extensively studied across a spectrum of physiologic and pathologic processes at the molecular, organi
Autor:
Tomris Mustafa, Ian Thistlethwaite, Adrian M. Eiden, Eberhard Weihe, Sunny Zhihong Jiang, Lee E. Eiden
Publikováno v:
Stress. 18:408-418
Acute restraint stress (ARS) for 3 hours causes CORT elevation in venous blood, which is accompanied by Fos up-regulation in the paraventricular nucleus (PVN) of male C57BL/6 mice. CORT elevation by ARS is attenuated in PACAP-deficient mice, but unaf
Publikováno v:
Psychoneuroendocrinology. 38:702-715
Depression; Stress resiliency; Forced swim test; HPA axis; Pituitary adenylate cyclase-activating polypeptide; Neuropeptide; Hypercortisolemia Summary The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) regulates activation of