Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Adrian M, Seifert"'
Autor:
David Digomann, Max Heiduk, Charlotte Reiche, Jessica Glück, Christoph Kahlert, Peter Mirtschink, Anna Klimova, Florian Bösch, Torsten Tonn, Jochen Gaedcke, Michael Ghadimi, Jürgen Weitz, Lena Seifert, Adrian M. Seifert
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) responds poorly to systemic treatment, including new immunotherapeutic approaches. Biomarkers are urgently needed for early disease detection, patient stratification for treatment, and response predict
Externí odkaz:
https://doaj.org/article/c19f5bd9248f4e8393bbb8bdfd097f13
Autor:
Yi Han, Pascal Drobisch, Alexander Krüger, Doreen William, Konrad Grützmann, Lukas Böthig, Heike Polster, Lena Seifert, Adrian M. Seifert, Marius Distler, Mathieu Pecqueux, Carina Riediger, Verena Plodeck, Heiner Nebelung, Georg F. Weber, Christian Pilarsky, Ulf Kahlert, Ulf Hinz, Susanne Roth, Thilo Hackert, Jürgen Weitz, Fang Cheng Wong, Christoph Kahlert
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-19 (2023)
Abstract Background The prognosis of pancreatic ductal adenocarcinoma (PDAC) is one of the most dismal of all cancers and the median survival of PDAC patients is only 6–8 months after diagnosis. While decades of research effort have been focused on
Externí odkaz:
https://doaj.org/article/79bb2f022f07438e98c676caf4fc5769
Autor:
Janusz vonRenesse, Felix vonBechtolsheim, Sophie Jonas, Lena Seifert, Tiago C. Alves, Adrian M. Seifert, Filip Komorek, Guergana Tritchkova, Mario Menschikowski, Ulrich Bork, Ronny Meisterfeld, Marius Distler, Triantafyllos Chavakis, Jürgen Weitz, Alexander M. Funk, Christoph Kahlert, Peter Mirtschink
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 298-309 (2023)
Abstract Background The detrimental impact of malnutrition and cachexia in cancer patients subjected to surgical resection is well established. However, how systemic and local metabolic alterations in cancer patients impact the serum metabolite signa
Externí odkaz:
https://doaj.org/article/e95fd939168840b18b6713cadf6df5aa
Autor:
Kuailu Lin, Franziska Baenke, Xixi Lai, Martin Schneider, Dominic Helm, Heike Polster, Venkatesh S. Rao, Nicole Ganig, Fang Cheng Wong, Lena Seifert, Adrian M. Seifert, Beatrix Jahnke, Nicole Kretschmann, Tjalf Ziemssen, Fee Klupp, Thomas Schmidt, Yi Han, Tim F. Weber, Verena Plodeck, Heiner Nebelung, Nathalie Schmitt, Felix Korell, Bruno C. Köhler, Carina Riediger, Jürgen Weitz, Nuh N. Rahbari, Christoph Kahlert
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-7 (2022)
Externí odkaz:
https://doaj.org/article/cc0c92fed0734076b039b2ba4af8065c
Autor:
Max Heiduk, Ioana Plesca, Jessica Glück, Luise Müller, David Digomann, Charlotte Reiche, Janusz von Renesse, Rahel Decker, Christoph Kahlert, Ulrich Sommer, Daniela E. Aust, Marc Schmitz, Jürgen Weitz, Lena Seifert, Adrian M. Seifert
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. At diagnosis, only 20% of patients with PDAC are eligible for primary resection. Neoadjuvant chemotherapy can enable surgical resection in 30%–40% of patients with locally a
Externí odkaz:
https://doaj.org/article/9a5a29027fcc4aadb45aea3cef95ab9a
Autor:
Ulrich Sommer, Jürgen Weitz, Daniela Aust, Maximilian Kießler, Ioana Plesca, Rebekka Wehner, Friederike Wilczkowski, Luise Müller, Antje Tunger, Xixi Lai, Anke Rentsch, Adrian M Seifert, Lena Seifert, Michael Bachmann, Martin Bornhäuser, Gustavo Baretton, Marc Schmitz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Plasmacytoid dendritic cells (pDCs) play a key role in the induction and maintenance of antitumor immunity. Conversely, they can act as tolerogenic DCs by inhibiting tumor-directed immune responses. Therefore, pDCs may profoundly influence
Externí odkaz:
https://doaj.org/article/47849b5e9eeb4ac59685008f84a1679c
Autor:
Janusz von Renesse, Felix von Bechtolsheim, Sophie Jonas, Lena Seifert, Tiago C. Alves, Adrian M. Seifert, Filip Komorek, Guergana Tritchkova, Mario Menschikowski, Ulrich Bork, Ronny Meisterfeld, Marius Distler, Triantafyllos Chavakis, Jürgen Weitz, Alexander M. Funk, Christoph Kahlert, Peter Mirtschink
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 14:298-309
The detrimental impact of malnutrition and cachexia in cancer patients subjected to surgical resection is well established. However, how systemic and local metabolic alterations in cancer patients impact the serum metabolite signature, thereby leadin
Autor:
Max Heiduk, Anna Klimova, Charlotte Reiche, David Digomann, Carolin Beer, Daniela E. Aust, Marius Distler, Jürgen Weitz, Adrian M. Seifert, Lena Seifert
Publikováno v:
Clinical Cancer Research.
Purpose: Immunotherapy has led to a fundamental shift in the treatment of several cancers. However, its efficacy in pancreatic ductal adenocarcinoma (PDAC) is limited. Understanding the expression of inhibitory immune checkpoint receptors (ICR) by in
Autor:
Juan A Santamaria-Barria, Shan Zeng, Jonathan B Greer, Michael J Beckman, Adrian M Seifert, Noah A Cohen, Jennifer Q Zhang, Megan H Crawley, Benjamin L Green, Jennifer K Loo, Joanna H Maltbaek, Ronald P DeMatteo
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216275 (2019)
IntroductionMurine Kupffer cells (KCs) comprise CD11bhi and F4/80hi subsets. Tissue-resident macrophages are known to express the tyrosine kinase receptors colony-stimulating factor 1 receptor (Csf1r) and Mer. However, the expression of Csf1r and Mer
Externí odkaz:
https://doaj.org/article/a80dafa8cf094624998c32df6c766544
Autor:
David Digomann, Johannes Strack, Max Heiduk, Ioana Plesca, Luise Rupp, Charlotte Reiche, Simone Nicolaus, Carolin Beer, Ulrich Sommer, Marc Schmitz, Marius Distler, Jürgen Weitz, Adrian M. Seifert, Lena Seifert
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2326
Immunotherapy has shown promising results in multiple solid tumors and hematological malignancies. However, pancreatic ductal adenocarcinoma (PDAC) has been largely refractory to current clinical immunotherapies. The V-domain Ig suppressor of T-cell