Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Adrian M, Guerrero"'
Autor:
Jenny Lam, Jeffery R. Deschamps, Adrian M. Guerrero, Greg H. Imler, Francisco O. Battiti, Alessandro Bonifazi, Sophie L. Cemaj, Rana Rais, Anver Basha Shaik, Barbara S. Slusher, Amy Hauck Newman
Publikováno v:
Journal of Medicinal Chemistry. 62:6287-6314
Because of the large degree of homology among dopamine D2-like receptors, discovering ligands capable of discriminating between the D2, D3, and D4 receptor subtypes remains a significant challenge....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3a86887c560fec57c3c2a409306d8d7
https://doi.org/10.1021/acs.jmedchem.9b00702
https://doi.org/10.1021/acs.jmedchem.9b00702
Autor:
Adrian M. Guerrero, Amy Hauck Newman, Hideaki Yano, Lei Shi, Vivek Kumar, Alexander F. Hoffman, Alessandro Bonifazi, Carl R. Lupica
Publikováno v:
ACS Pharmacology & Translational Science
The discovery of functionally biased and physiologically beneficial ligands directed toward G-protein coupled receptors (GPCRs) has provided the impetus to design dopamine D2 receptor (D2R) targeted molecules that may be therapeutically advantageous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09da799ecb95cf7d821bacb17d3989ed
https://doi.org/10.1021/acsptsci.8b00060
https://doi.org/10.1021/acsptsci.8b00060
Autor:
Ravi Kumar Verma, R. Benjamin Free, Lei Shi, Vivek Kumar, Adrian M. Guerrero, Amy Hauck Newman, David R. Sibley, Amy E. Moritz, Alessandro Bonifazi, J. Robert Lane
Publikováno v:
ACS Chem Neurosci
The D3 dopamine receptor (D3R) has been suggested as a drug target for the treatment of a number of neuropsychiatric disorders, including substance use disorders (SUD). Many D3R-selective antagonists are bivalent in nature in that they engage two dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939fe68655724ab77d56c553c773f9a9
https://europepmc.org/articles/PMC8262072/
https://europepmc.org/articles/PMC8262072/
Autor:
Zheng-Xiong Xi, Sophie L. Cemaj, Alexandra J. Gadiano, Anver Basha Shaik, Rana Rais, Jenny Lam, Vivek Kumar, Amy Hauck Newman, Barbara S. Slusher, Adrian M. Guerrero, Alessandro Bonifazi
Publikováno v:
J Med Chem
Dopamine D(3) receptors (D(3)R) play a critical role in neuropsychiatric conditions including substance use disorders (SUD). Recently, we reported a series of N-(3-hydroxy-4-(4-phenylpiperazin-1yl)butyl)-1H-indole-2-carboxamide analogues as high affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5f4d9f85fc14b5f81fc7f0712360f6
https://europepmc.org/articles/PMC8830247/
https://europepmc.org/articles/PMC8830247/
Autor:
Francisco O, Battiti, Sophie L, Cemaj, Adrian M, Guerrero, Anver Basha, Shaik, Jenny, Lam, Rana, Rais, Barbara S, Slusher, Jeffery R, Deschamps, Greg H, Imler, Amy Hauck, Newman, Alessandro, Bonifazi
Publikováno v:
J Med Chem
Due to the large degree of homology among dopamine D(2)-like receptors, discovering ligands capable of discriminating between the D(2), D(3) and D(4) receptor subtypes remains a significant challenge. Previous work has exemplified the use of bitopic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f80576bccab4763a3aff210449f6fbba
https://pubmed.ncbi.nlm.nih.gov/31257877
https://pubmed.ncbi.nlm.nih.gov/31257877
Autor:
DeMarcus K. Crews, Samuel O. Figueroa Lazú, Jeffrey Mowat, Andrew J. Phillips, Sivaraman Dandapani, Steven James Ferrara, Sina Haftchenary, Shawn D. Nelson, Stuart L. Schreiber, Marcus Bauser, Cristina Brackeen, Thomas Brumby, Adrian M. Guerrero, Laura Furst, Žarko V. Bošković, Juan C. Serrano
Publikováno v:
ACS Combinatorial Science
Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005251dd6def99ba476fe541d99044ad
http://europepmc.org/articles/PMC5022782
http://europepmc.org/articles/PMC5022782
Autor:
Alessandro Bonifazi, Ravi Kumar Verma, R. Benjamin Free, Vivek Kumar, Adrian M. Guerrero, J. Robert Lane, David R. Sibley, Amy Hauck Newman, Lei Shi, Amy E. Moritz
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b19c8c7500615264567a5033152e6a65
https://doi.org/10.1096/fasebj.2018.32.1_supplement.827.12
https://doi.org/10.1096/fasebj.2018.32.1_supplement.827.12
Autor:
Alessandro, Bonifazi, Hideaki, Yano, Michael P, Ellenberger, Ludovic, Muller, Vivek, Kumar, Mu-Fa, Zou, Ning Sheng, Cai, Adrian M, Guerrero, Amina S, Woods, Lei, Shi, Amy Hauck, Newman
Publikováno v:
J Med Chem
The development of bivalent ligands has attracted interest as a way to potentially improve the selectivity and/or affinity for a specific receptor subtype. The ability to bind two distinct receptor binding sites simultaneously can allow the selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2b470938ccfdcea008a46e63121ad33
https://pubmed.ncbi.nlm.nih.gov/28300398
https://pubmed.ncbi.nlm.nih.gov/28300398
Autor:
Debasish Bandyopadhyay, Jesse R. Rivera, Robert K. Dearth, Adrian M. Guerrero, Jorge L. Sanchez, John D. Short, Jose C. Granados, Fang Mei Chang, Bimal K. Banik, Gildardo Rivera
Publikováno v:
European Journal of Medicinal Chemistry. 82:574-583
Direct nitration of estradiol was carried out using metal nitrates on solid surfaces under mild condition, and a combination of bismuth nitrate pentahydrate impregnated KSF clay was found to be the best reagent to synthesize 2- and 4-nitroestradiol e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673e058738cb78dbc5e5c0977455d98f
https://doi.org/10.1016/j.ejmech.2014.06.010
https://doi.org/10.1016/j.ejmech.2014.06.010
Autor:
Jorge L. Sanchez, Jose C. Granados, Adrian M. Guerrero, Bimal K. Banik, Debasish Bandyopadhyay, Fang Mei Chang, Johnny D Short
Publikováno v:
European journal of medicinal chemistry. 89
Polycyclic aromatic hydrocarbons are widespread in nature with a toxicity range from non-toxic to extremely toxic. A series of pyrenyl derivatives has been synthesized following a four-step strategy where the pyrene nucleus is attached with a basic h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ac87185f07ce5b1a42bbf0c39b177b
https://pubmed.ncbi.nlm.nih.gov/25462285
https://pubmed.ncbi.nlm.nih.gov/25462285