Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Adrian L Oblak"'
Autor:
Nicole Ramos Solis, Anthony Cannon, Tinslee Dilday, Melissa Abt, Adrian L. Oblak, Adam C. Soloff, Mark H. Kaplan, Elizabeth S. Yeh
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). TNBC tumors are not sensitive to endocrine therapy, and standardized TNBC treatment
Externí odkaz:
https://doaj.org/article/3b9dc2bcc945418ea6c7b52e97286e08
Autor:
Meichen Yu, Shannon L. Risacher, Kwangsik T. Nho, Qiuting Wen, Adrian L. Oblak, Frederick W. Unverzagt, Liana G. Apostolova, Martin R. Farlow, Jared R. Brosch, David G. Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J. Saykin
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113691- (2024)
Summary: Amyloid-β (Aβ) and tau proteins accumulate within distinct neuronal systems in Alzheimer’s disease (AD). Although it is not clear why certain brain regions are more vulnerable to Aβ and tau pathologies than others, gene expression may p
Externí odkaz:
https://doaj.org/article/ba0c909262094aae9ec7b638a2fb465f
Autor:
Season K. Wyatt-Johnson, Holly N. Kersey, Juan F. Codocedo, Kathy L. Newell, Gary E. Landreth, Bruce T. Lamb, Adrian L. Oblak, Randy R. Brutkiewicz
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Neuroinflammation is an important feature of Alzheimer’s disease (AD). Understanding which aspects of the immune system are important in AD may lead to new therapeutic approaches. We study the major histocompatibility complex cl
Externí odkaz:
https://doaj.org/article/badbf220d5344ded9364a3ed747305d8
Autor:
Cynthia D. Jesudason, Emily R. Mason, Shaoyou Chu, Adrian L. Oblak, June Javens‐Wolfe, Mustapha Moussaif, Greg Durst, Philip Hipskind, Daniel E. Beck, Jiajun Dong, Ovini Amarasinghe, Zhong‐Yin Zhang, Adam K. Hamdani, Kratika Singhal, Andrew D. Mesecar, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Disha M. Soni, Murugesh Kandasamy, Andrea R. Masters, Sara K Quinney, Suzanne Doolen, Hasi Huhe, Stacey J. Sukoff Rizzo, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate‐5‐phosphatase (INPP5D), which encodes Src homology 2 (SH2) domain–containing inositol polyphosphat
Externí odkaz:
https://doaj.org/article/4d6f6a10135b4cdbb5e5fc4dd51947a7
Autor:
Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Evan J. Messenger, Brad T. Casali, Miguel Moutinho, Yunlong Liu, Adrian L. Oblak, Bruce T. Lamb, Gary E. Landreth, Stephanie J. Bissel, Kwangsik Nho
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background Alzheimer’s disease (AD) is characterized by robust microgliosis and phenotypic changes that accompany disease pathogenesis. Accumulating evidence from genetic studies suggests the importance of phospholipase C γ 2 (PLCG2) in l
Externí odkaz:
https://doaj.org/article/214bb87193a04e81a5564cbf54f44674
Autor:
Surendra Maharjan, Andy P. Tsai, Peter B. Lin, Cynthia Ingraham, Megan R. Jewett, Gary E. Landreth, Adrian L. Oblak, Nian Wang
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/166eef53ffd04b3bb18289528c6c2d02
Autor:
Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L. Oblak, Cristian A. Lasagna-Reeves
Publikováno v:
Cells, Vol 12, Iss 12, p 1597 (2023)
The role of TREM2 in Alzheimer’s disease (AD) is not fully understood. Previous studies investigating the effect of TREM2 deletion on tauopathy mouse models without the contribution of b-amyloid have focused only on tau overexpression models. Herei
Externí odkaz:
https://doaj.org/article/f8243020efa242c8bd809996117876e2
Autor:
Surendra Maharjan, Andy P. Tsai, Peter B. Lin, Cynthia Ingraham, Megan R. Jewett, Gary E. Landreth, Adrian L. Oblak, Nian Wang
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
PurposeTo evaluate the age-dependent microstructure changes in 5xFAD mice using high-resolution diffusion tensor imaging (DTI).MethodsThe 5xFAD mice at 4, 7.5, and 12 months and the wild-type controls at 4 months were scanned at 9.4T using a 3D echo-
Externí odkaz:
https://doaj.org/article/a101c0bc7ca54db6b3d837718b536712
Autor:
Adrian L. Oblak, Kevin P. Kotredes, Ravi S. Pandey, Alaina M. Reagan, Cynthia Ingraham, Bridget Perkins, Christopher Lloyd, Deborah Baker, Peter B. Lin, Disha M. Soni, Andy P. Tsai, Scott A. Persohn, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Jill A. Meyer, Johnathan S. Peters, Lucas L. Figueiredo, Michael Sasner, Paul R. Territo, Stacey J. Sukoff Rizzo, Gregory W. Carter, Bruce T. Lamb, Gareth R. Howell
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Obesity is recognized as a significant risk factor for Alzheimer’s disease (AD). Studies have supported the notion that obesity accelerates AD-related pathophysiology in mouse models of AD. The majority of studies, to date, have focused on the use
Externí odkaz:
https://doaj.org/article/b6814a937f1741338ed611ffbc142ff3
Autor:
Christoph Preuss, Ravi Pandey, Erin Piazza, Alexander Fine, Asli Uyar, Thanneer Perumal, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Lara M. Mangravite, Bruce T. Lamb, Adrian L. Oblak, Gareth R. Howell, Michael Sasner, Benjamin A. Logsdon, the MODEL-AD Consortium, Gregory W. Carter
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-16 (2020)
Abstract Background Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack of frank neuropathology from models based on com
Externí odkaz:
https://doaj.org/article/8775aca8b63c4f6aa8ee61934f0936b1