Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Adrian K, West"'
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 323-333 (2006)
Apoptotic-like changes in the neocortex of control, pathologically aged and Alzheimer's disease (AD) cases were investigated. There was no increase in labeling or change in localization of labeling that distinguished between these cases for active ca
Externí odkaz:
https://doaj.org/article/f8c7fb3e2ee14fe0961a573201de2411
Publikováno v:
Neurobiology of Disease, Vol 18, Iss 2, Pp 286-295 (2005)
This study investigated the role of α-internexin in the neuronal alterations associated with β-amyloid plaque formation in Alzheimer's disease (AD). Cortical neurons could be defined by their variable content of neurofilament (NF) triplet and α-in
Externí odkaz:
https://doaj.org/article/d7385e1c58e84e5f90200f07c80000d4
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 5, Pp 349-356 (1998)
We have examined the possible role of metallothionein I/II (MT I/II) in Alzheimer's disease (AD), with a focus on the cellular localization of MT I/II relative to the astrocyte marker, glial fibrillary acidic protein (GFAP). In AD and preclinical AD
Externí odkaz:
https://doaj.org/article/487dbca8c4574cf38c92b68504cd4fe5
Autor:
Michael W Pankhurst, David A Gell, Chris W Butler, Matthew T K Kirkcaldie, Adrian K West, Roger S Chung
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31185 (2012)
UNLABELLED: Experiments with transgenic over-expressing, and null mutant mice have determined that metallothionein-I and -II (MT-I/II) are protective after brain injury. MT-I/II is primarily a zinc-binding protein and it is not known how it provides
Externí odkaz:
https://doaj.org/article/10b5c1aa19d042f3bc6bd541ea4f1ccb
Autor:
Shannon Ray, Claire Howells, Emma D Eaton, Chris W Butler, Lana Shabala, Paul A Adlard, Adrian K West, William R Bennett, Gilles J Guillemin, Roger S Chung
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19026 (2011)
BackgroundOne of the key pathological features of AD is the formation of insoluble amyloid plaques. The major constituent of these extracellular plaques is the beta-amyloid peptide (Aβ), although Aβ is also found to accumulate intraneuronally in AD
Externí odkaz:
https://doaj.org/article/9c68d23971814f2ca8bb9aaff0072687
Autor:
Roger S Chung, Claire Howells, Emma D Eaton, Lana Shabala, Kairit Zovo, Peep Palumaa, Rannar Sillard, Adele Woodhouse, William R Bennett, Shannon Ray, James C Vickers, Adrian K West
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12030 (2010)
BACKGROUND: A major pathological hallmark of AD is the deposition of insoluble extracellular beta-amyloid (Abeta) plaques. There are compelling data suggesting that Abeta aggregation is catalysed by reaction with the metals zinc and copper. METHODOLO
Externí odkaz:
https://doaj.org/article/b844c4b59b574b3c8779ab2d2108c6ba
Autor:
Katherine E A, Lewis, William, Bennett, Christopher L, Blizzard, Adrian K, West, Roger S, Chung, Meng Inn, Chuah
Publikováno v:
The European journal of neuroscienceREFERENCES. 52(4)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterised by the degeneration of motor neurons innervating skeletal muscle. The mechanisms underlying neurodegeneration in ALS are not yet fully elucidated, and with curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8e91731331f5252681778bbb1eb7f53
https://pubmed.ncbi.nlm.nih.gov/31954073
https://pubmed.ncbi.nlm.nih.gov/31954073
Autor:
Lachlan S. Brown, Adrian K. West, Bruce V. Taylor, Macarena Pavez, Lisa Foa, Robert Gasperini, LM Landowski
Publikováno v:
The Journal of Biological Chemistry
The low-density lipoprotein receptor-related protein receptors 1 and 2 (LRP1 and LRP2) are emerging as important cell signaling mediators in modulating neuronal growth and repair. We examined whether LRP1 and LRP2 are able to mediate a specific aspec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dc6f79d87ed0642b56be57442b48a1
http://europepmc.org/articles/PMC4714193
http://europepmc.org/articles/PMC4714193
Autor:
Adrian K. West, Adrian Cuda Banda Meedeniya, Catherine A. Blizzard, Marion Quilty, Gilles J. Guillemin, James C. Vickers, M.B. Wong, Dean Louis Pountney, Alex Rcom-H'cheo-Gauthier, Wei Ping Gai, Rowan A. W. Radford, Roger S. Chung, Emma D. Eaton, Anwar Norazit, Tracey C. Dickson
Publikováno v:
Molecular and Cellular Neuroscience. 65:68-81
Multiple system atrophy (MSA) exhibits widespread astrogliosis together with α-synuclein (α-syn) glial cytoplasmic inclusions (GCIs) in mature oligodendrocytes. We quantified astrocyte activation by morphometric analysis of MSA cases, and investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7c49bdb7cca359794db0224cc972df
https://doi.org/10.1016/j.mcn.2015.02.015
https://doi.org/10.1016/j.mcn.2015.02.015