Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Adrian J. Ryan"'
Publikováno v:
Xenobiotica. 20:457-470
1. 3H-Dibenz[a,j]acridine (DBAJAC) metabolism occurred readily in vitro in incubations with hepatocytes from phenobarbital-pretreated, 3-methylcholanthrene-pretreated and untreated rats, with the formation of water-soluble conjugates and unconjugated
Autor:
Gerald M. Holder, C. E. Scharping, Sugiyanto, D. J. Birkett, Adrian J. Ryan, Michael E. McManus
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(11)
1. The metabolism of 3H-benzo[a]pyrene (BP), 3H-7-methylbenz[c]acridine (7MBAC) and 3H-dibenz[a,j]acridine (DBAJAC) have been studied in human liver microsomes from 13 subjects. 2. When the metabolism of these carcinogens to more polar ethyl acetate-
Publikováno v:
Journal of chromatography. 530(2)
Analytical separations and quantification of eight metabolites of benzo[a]pyrene, nine metabolites of 7-methylbenz[c]acridine and nine metabolites of dibenz[a,j]acridine have been carried out on two reversed-phase high-performance liquid chromatograp
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 28(3)
Mutagen production was examined in lamb and beef in relation to certain common household cooking methods. Mutagenicity was assessed, after extraction of the basic fraction of cooked meat samples, using Salmonella typhimurium strain TA1538 with added
Publikováno v:
Carcinogenesis. 7:1371-1378
The metabolism of the carcinogenic pentacyclic azaaromatic compound, dibenz[a,j]acridine, has been examined in liver microsomal incubations using preparations from 3-methylcholanthrene-pretreated Wistar rats. Using authentic synthetic standards, u.v.
Publikováno v:
Mutation Research/Genetic Toxicology. 158:111-117
Liver microsomal enzymes are essential for the detection of benzo[a]pyrene (B[a]P)-mediated mutagenesis in the Salmonella/mammalian microsome mutagenicity test and, furthermore, this mutagenicity is considerably enhanced by induction of hepatic enzym
Publikováno v:
Xenobiotica. 8:761-768
Curcumin labelled with deuterium and tritium was prepared. Oral and intraperitoneal doses of [3H]curcumin led to the faecal excretion of most of the radioactivity. 2. Intravenous and intraperitoneal doses of [3H]curcumin were well excreted in the bil
Autor:
Peter J. Little, Adrian J. Ryan
Publikováno v:
Biochemical Pharmacology. 31:1795-1798
Publikováno v:
Environmental Health Perspectives
With 8-(14)C-styrene oxide as substrate, specific glutathione S-transferase and epoxide hydrase activities were determined in subcellular fractions of liver, lungs, kidney, and intestinal mucosa from rabbit, rat, and guinea pig. Liver had the highest
Publikováno v:
Biochemical Pharmacology. 30:2685-2690
An enzyme assay for the metabolism of the carcinogenic aza-aromatic polycyclic compound 7-methylbenz[c]acridine has been developed using a modification of a radiochemical assay described for the polycyclic aromatic hydrocarbon benzo[a]pyrene by DePie