Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Adrian J. McNairn"'
Publikováno v:
Nature
Genomic instability can trigger cellular responses that include checkpoint activation, senescence and inflammation1,2. Although genomic instability has been extensively studied in cell culture and cancer paradigms, little is known about its effect du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab4e8c474ecc4c25fc4140299709e29
http://europepmc.org/articles/PMC6497049
http://europepmc.org/articles/PMC6497049
Autor:
Jordana C. Bloom, Matt Kanke, Nicolas Buchon, Michael J. Shanahan, Bailey C.E. Peck, Rebecca L. Cubitt, Lukas E. Dow, Breanna Sheahan, Shengli Ding, Wendy A. Pitman, Alessandro Bonfini, Praveen Sethupathy, Christopher M. Dekaney, Vera D. Rinaldi, Ennessa G. Curry, Elia D. Tait-Wojno, Ajeet Singh, Oyebola O. Oyesola, Adrian J. McNairn, Yu-Han Hung, Jonathan W. Villanueva, John C. Schimenti
SummaryThe role of individual miRNAs in small intestinal (SI) epithelial homeostasis is under-explored. In this study, we discovered that miR-375 is among the most enriched miRNAs in intestinal crypts and stem cells (ISCs), especially facultative ISC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc1408182c0c1329b8c1ce64f8c16cd6
https://doi.org/10.1101/2020.10.01.321612
https://doi.org/10.1101/2020.10.01.321612
Publikováno v:
Genetics. 205:529-537
The mammalian Mcm-domain containing 2 (Mcmdc2) gene encodes a protein of unknown function that is homologous to the minichromosome maintenance family of DNA replication licensing and helicase factors. Drosophila melanogaster contains two separate gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10253dc9fc63c71428b8f4cc5d0fbfb
https://doi.org/10.1534/genetics.116.196808
https://doi.org/10.1534/genetics.116.196808
The mammalianMcm-domain containing 2(Mcmdc2) gene encodes a protein of unknown function that is homologous to the mini-chromosome maintenance family of DNA replication licensing and helicase factors.Drosophila melanogastercontains two separate genes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da2de3f48830fa0398ed7c32a3a650f
https://doi.org/10.1101/080887
https://doi.org/10.1101/080887
Autor:
Adrian J. McNairn, Barbara L Fallon, Teresa L. Southard, Ethan Cerami, Vera D. Rinaldi, Adam D. Pfefferle, Lishuang Shen, John C. Schimenti, Marsha D. Wallace, Charles M. Perou
Publikováno v:
Genetics. 192:385-396
Identifying genomic alterations driving breast cancer is complicated by tumor diversity and genetic heterogeneity. Relevant mouse models are powerful for untangling this problem because such heterogeneity can be controlled. Inbred Chaos3 mice exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e26fedabb94935daf3615785c32cbe7
https://doi.org/10.1534/genetics.112.142802
https://doi.org/10.1534/genetics.112.142802
Autor:
Adrian J. McNairn, Géraldine Guasch
Publikováno v:
European Journal of Dermatology. 21:21-28
Transition zones (TZs) are regions in the body where two different types of epithelial tissue meet resulting in the appearance of a distinct abrupt transition. These TZs are found in numerous locations within the body, including the cornea-conjunctiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64ca07d7d8c3688e13b4c6827ab5252
https://doi.org/10.1684/ejd.2011.1267
https://doi.org/10.1684/ejd.2011.1267
Autor:
Matthew Goering, Sue L. Jaspersen, Scarlett Gard, Adrian J. McNairn, Shuai Lu, Jennifer L. Gerton, Bo Xiong
Publikováno v:
Cell Cycle. 9:3335-3347
The cohesin network has an essential role in chromosome segregation, but also plays a role in DNA damage repair. Eco1 is an acetyltransferase that targets subunits of the cohesin complex and is involved in both the chromosome segregation and DNA dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4c3e9f553c1cb1091e31d8b1cb7b97
https://doi.org/10.4161/cc.9.16.12673
https://doi.org/10.4161/cc.9.16.12673
Autor:
Adrian J. McNairn, Jennifer L. Gerton
Publikováno v:
Chromosome Research. 17:155-163
The evolutionarily conserved cohesin proteins Smc1, Smc3, Rad21 (Mcd1), and Scc3 function in the cohesin complex that provides the basis for chromosome cohesion and is involved in gene regulation. Understanding how these proteins link together the ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f25c18522d06ce3a6d37ea840df51fd
https://doi.org/10.1007/s10577-008-9007-9
https://doi.org/10.1007/s10577-008-9007-9
Autor:
Jennifer L. Gerton, Adrian J. McNairn
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 647:103-111
Over 75 years ago, two human genetic disorders were initially described and named for their founding physicians: Cornelia de Lange (CdLS) and Roberts syndrome (RBS)/SC Phocomelia (SC). In the past 4 years, genetic studies of patients have revealed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c56866a0196bef83bf938bb08cc164
https://doi.org/10.1016/j.mrfmmm.2008.08.010
https://doi.org/10.1016/j.mrfmmm.2008.08.010
Autor:
Adrian J. McNairn, Jennifer L. Gerton
Publikováno v:
Trends in Genetics. 24:382-389
Since their discovery, the cohesin proteins have been intensely studied in multiple model systems to determine the mechanism of chromosome cohesion. Recent studies have demonstrated that cohesin is much more than a molecular glue that holds chromosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e845068c9edf0129a8d30dd8307e18
https://doi.org/10.1016/j.tig.2008.06.002
https://doi.org/10.1016/j.tig.2008.06.002