Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Adrian J. Lambert"'
Autor:
Martin D. Brand, Reinald Pamplona, Adrian J. Lambert, Jake Jacobson, Satomi Miwa, Tapiwanashe Magwere, Linda Partridge, Yasmine Driege, Manuel Portero-Otin
Publikováno v:
Aging Cell. 9:466-477
Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases with age but does not reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2870829fdaf37f911f25ce4117afc191
https://doi.org/10.1111/j.1474-9726.2010.00573.x
https://doi.org/10.1111/j.1474-9726.2010.00573.x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1777:397-403
We investigated the effects of diphenyleneiodonium (DPI) on superoxide production by complex I in mitochondria isolated from rat skeletal muscle. Superoxide production was measured indirectly as hydrogen peroxide production. In a conventional medium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064afefe6085daf634a1e82d06387d37
https://doi.org/10.1016/j.bbabio.2008.03.005
https://doi.org/10.1016/j.bbabio.2008.03.005
Autor:
Adrian J. Lambert, Martin D. Brand
Publikováno v:
Aging Cell. 6:417-420
This review focuses on some of the 'hot topics' that fall under the general heading 'mitochondria and aging'. For each selected topic, we highlight recent publications that have either addressed specific problems within the field or presented novel f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464033206706f7e54e18f0a0b53332e3
https://doi.org/10.1111/j.1474-9726.2007.00316.x
https://doi.org/10.1111/j.1474-9726.2007.00316.x
Autor:
Brian J. Merry, Adrian J. Lambert
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 60:175-180
To investigate the hypothesis that caloric restriction alters mitochondrial function in situ, intact hepatocytes were isolated from fully fed and calorie-restricted (55% of control food intake, 4 months duration) male Brown-Norway rats at 6 months of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6752ffbabf981889da04ff0df8cd31
https://doi.org/10.1093/gerona/60.2.175
https://doi.org/10.1093/gerona/60.2.175
Publikováno v:
Mechanisms of Ageing and Development. 125:529-538
To gain insight into the anti-ageing mechanisms of caloric restriction (CR), liver mitochondria were isolated from male Brown-Norway rats of different ages (fully fed control and CR) and various specific markers of non-enzymatic protein modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d9ea20db2fe9a94c362db799939332
https://doi.org/10.1016/j.mad.2004.06.002
https://doi.org/10.1016/j.mad.2004.06.002
Autor:
Karim S. Echtay, Stephen J. Roebuck, Reinald Pamplona, Telma C. Esteves, Steven Wang, Adrian J. Lambert, Julian L. Pakay, Antonio Vidal-Puig, Mika B. Jekabsons, Manuel Portero-Otin, Martin D. Brand
Publikováno v:
The EMBO Journal. 22:4103-4110
Oxidative stress and mitochondrial dysfunction are associated with disease and aging. Oxidative stress results from overproduction of reactive oxygen species (ROS), often leading to peroxidation of membrane phospholipids and production of reactive al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373a3e4ca21938bee87e926cb744c14b
https://doi.org/10.1093/emboj/cdg412
https://doi.org/10.1093/emboj/cdg412
Autor:
Adrian J, Lambert, Martin D, Brand
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 554
Oxidative damage to cellular macromolecules is believed to underlie the development of many pathological states and aging. The agents responsible for this damage are generally thought to be reactive oxygen species, such as superoxide, hydrogen peroxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de0f54fc38a5db59683ada08b7c4f2b6
https://pubmed.ncbi.nlm.nih.gov/19513674
https://pubmed.ncbi.nlm.nih.gov/19513674
Autor:
Julie A. Buckingham, Adrian J. Lambert, Ting Yang, Rochelle Buffenstein, Andrej Podlutsky, Steven N. Austad, Thomas H. Kunz, Martin D. Brand, Helen M. Boysen
Publikováno v:
Aging cell. 6(5)
An inverse correlation between free radical production by isolated mitochondria and longevity in homeotherms has been reported, but previous comparative studies ignored possible confounding effects of body mass and phylogeny. We investigated this cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a7df1fe30624cf5bed3704fac695a4
https://pubmed.ncbi.nlm.nih.gov/17596208
https://pubmed.ncbi.nlm.nih.gov/17596208
Autor:
Adrian J. Lambert, Martin D. Brand
Publikováno v:
The Journal of biological chemistry. 279(38)
Neither the route of electron transport nor the sites or mechanism of superoxide production in mitochondrial complex I has been established. We examined the rates of superoxide generation (measured as hydrogen peroxide production) by rat skeletal mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21de06187b809fcae122fee5ac867063
https://pubmed.ncbi.nlm.nih.gov/15262965
https://pubmed.ncbi.nlm.nih.gov/15262965
Autor:
Martin D. Brand, Adrian J. Lambert
Publikováno v:
The Biochemical journal. 382(Pt 2)
The relationship between protonmotive force and superoxide production by mitochondria is poorly understood. To address this issue, the rate of superoxide production from complex I of rat skeletal muscle mitochondria incubated under a variety of condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe5f7bf2ec965a6d12bddb870eb6ff3
https://pubmed.ncbi.nlm.nih.gov/15175007
https://pubmed.ncbi.nlm.nih.gov/15175007