Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Adrian J Wolstenholme"'
Autor:
Shivani Choudhary, Samuel K Buxton, Sreekanth Puttachary, Saurabh Verma, Gunnar R Mair, Ciaran J McCoy, Barbara J Reaves, Adrian J Wolstenholme, Richard J Martin, Alan P Robertson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008396 (2020)
Nematode parasites infect approximately 1.5 billion people globally and are a significant public health concern. There is an accepted need for new, more effective anthelmintic drugs. Nicotinic acetylcholine receptors on parasite nerve and somatic mus
Externí odkaz:
https://doaj.org/article/aaa14d3e9cdb433296675d4c9b44bba7
Autor:
Alexandra Blanchard, Fabrice Guégnard, Claude L Charvet, Anna Crisford, Elise Courtot, Christine Sauvé, Abdallah Harmache, Thomas Duguet, Vincent O'Connor, Philippe Castagnone-Sereno, Barbara Reaves, Adrian J Wolstenholme, Robin N Beech, Lindy Holden-Dye, Cedric Neveu
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1006996 (2018)
Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic paralysis by activating acetylcholine receptors (AChRs) expressed in nematode body wall muscles
Externí odkaz:
https://doaj.org/article/28410ae1fb11412eb1de52ffddf3d9f6
Autor:
Ciaran J McCoy, Barbara J Reaves, Steeve Giguère, Ruby Coates, Balázs Rada, Adrian J Wolstenholme
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005279 (2017)
BACKGROUND:Wuchereria bancrofti, Brugia malayi and Brugia timori infect over 100 million people worldwide and are the causative agents of lymphatic filariasis. Some parasite carriers are amicrofilaremic whilst others facilitate mosquito-based disease
Externí odkaz:
https://doaj.org/article/a9c9978a135c483e93810f3938886800
Autor:
Elise Courtot, Claude L Charvet, Robin N Beech, Abdallah Harmache, Adrian J Wolstenholme, Lindy Holden-Dye, Vincent O'Connor, Nicolas Peineau, Debra J Woods, Cedric Neveu
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005267 (2015)
Acetylcholine receptors are pentameric ligand-gated channels involved in excitatory neuro-transmission in both vertebrates and invertebrates. In nematodes, they represent major targets for cholinergic agonist or antagonist anthelmintic drugs. Despite
Externí odkaz:
https://doaj.org/article/0e442599256b407ca8e198036851e625
Autor:
Daniel Kulke, Georg von Samson-Himmelstjerna, Sandra M Miltsch, Adrian J Wolstenholme, Aaron R Jex, Robin B Gasser, Cristina Ballesteros, Timothy G Geary, Jennifer Keiser, Simon Townson, Achim Harder, Jürgen Krücken
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 12, p e3401 (2014)
The cyclooctadepsipeptide emodepside and its parent compound PF1022A are broad-spectrum nematicidal drugs which are able to eliminate nematodes resistant to other anthelmintics. The mode of action of cyclooctadepsipeptides is only partially understoo
Externí odkaz:
https://doaj.org/article/eee59e0458bc4c27a811a0d3f320d95e
Autor:
Susan K Glendinning, Steven D Buckingham, David B Sattelle, Susan Wonnacott, Adrian J Wolstenholme
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22390 (2011)
Anthelmintic resistance is a major problem in livestock farming, especially of small ruminants, but our understanding of it has been limited by the difficulty in carrying out functional genetic studies on parasitic nematodes. An important nematode in
Externí odkaz:
https://doaj.org/article/a662dd775a1b4dd0ad04aaf05fc29d7a
Autor:
Sally M Williamson, Alan P Robertson, Laurence Brown, Tracey Williams, Debra J Woods, Richard J Martin, David B Sattelle, Adrian J Wolstenholme
Publikováno v:
PLoS Pathogens, Vol 5, Iss 7, p e1000517 (2009)
Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasit
Externí odkaz:
https://doaj.org/article/221d850dab8b405b84f62b1d11491fcd
Publikováno v:
International Journal for Parasitology.
Autor:
Vincent Starai, Allyson T. Loy, Lucinda N. Shaffer, Sophia T. Gavalas, Anna A. Mermilliod, Frederick Quinn, Adrian J. Wolstenholme, Barbara J. Reaves
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Its success as a pathogen is dependent on an arsenal of secreted virulence factors which target host cell organelles. In this report, we have characterized the effects of two pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15a993cff97fb5b35bdbf42bf5136e34
https://doi.org/10.22541/au.167659571.17510233/v1
https://doi.org/10.22541/au.167659571.17510233/v1
Autor:
Sabine Specht, Achim Harder, Steffen Hahnel, Ivan Scandale, Marc P. Hübner, Suzanne Gokool, Senyo Tagboto, Daniel Kulke, Achim Hoerauf, Simon Townson, Guilherme G. Verocai, Mary J. Maclean, Stefan J. Frohberger, Adrian J. Wolstenholme, Martin Glenschek-Sieberth
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 27-35 (2021)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 27-35 (2021)
Filariae are vector-borne nematodes responsible for an enormous burden of disease. Human lymphatic filariasis, caused by Wuchereria bancrofti, Brugia malayi, and Brugia timori, and onchocerciasis (caused by Onchocerca volvulus) are neglected parasiti