Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Adrian J Wolstenholme"'
Autor:
Marc P. Hübner, Simon Townson, Suzanne Gokool, Senyo Tagboto, Mary J. Maclean, Guilherme G. Verocai, Adrian J. Wolstenholme, Stefan J. Frohberger, Achim Hoerauf, Sabine Specht, Ivan Scandale, Achim Harder, Martin Glenschek-Sieberth, Steffen R. Hahnel, Daniel Kulke
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 27-35 (2021)
Filariae are vector-borne nematodes responsible for an enormous burden of disease. Human lymphatic filariasis, caused by Wuchereria bancrofti, Brugia malayi, and Brugia timori, and onchocerciasis (caused by Onchocerca volvulus) are neglected parasiti
Externí odkaz:
https://doaj.org/article/252f3ff0161446448f30716b92ceb613
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-10 (2021)
Abstract Background Ivermectin is widely used in human and animal medicine to treat and prevent parasite nematode infections. It has been suggested that its mode of action requires the host immune system, as it is difficult to reproduce its clinical
Externí odkaz:
https://doaj.org/article/0f4d5c1206ec43d0b91c9566fcdc3fd1
Autor:
Melissa M. George, Adriano F. Vatta, Sue B. Howell, Bob E. Storey, Ciaran J. McCoy, Adrian J. Wolstenholme, Elizabeth M. Redman, John S. Gilleard, Ray M. Kaplan
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss , Pp 134-143 (2021)
A population of Haemonchus contortus that was highly resistant to benzimidazoles and avermectin/milbemycins with a subpopulation that was resistant to levamisole, was replaced with a susceptible laboratory isolate of H. contortus in a flock of sheep.
Externí odkaz:
https://doaj.org/article/daffe7448bdc4defb193cf34c0e7a820
Autor:
Jane E. Hodgkinson, Ray M. Kaplan, Fiona Kenyon, Eric R. Morgan, Andrew W. Park, Steve Paterson, Simon A. Babayan, Nicola J. Beesley, Collette Britton, Umer Chaudhry, Stephen R. Doyle, Vanessa O. Ezenwa, Andy Fenton, Sue B. Howell, Roz Laing, Barbara K. Mable, Louise Matthews, Jennifer McIntyre, Catherine E. Milne, Thomas A. Morrison, Jamie C. Prentice, Neil D. Sargison, Diana J.L. Williams, Adrian J. Wolstenholme, Eileen Devaney
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 10, Iss , Pp 51-57 (2019)
Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in ‘refu
Externí odkaz:
https://doaj.org/article/0f597d86787e47a29603f6805ad59e1f
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 10, Iss , Pp 45-50 (2019)
The macrocyclic lactone anthelmintics are the only class of drug currently used to prevent heartworm disease. Their extremely high potency in vivo is not mirrored by their activity against Dirofilaria immitis larvae in vitro, leading to suggestions t
Externí odkaz:
https://doaj.org/article/bca73a66d59f4d89a1242afc9672d04b
Autor:
Molly D. Savadelis, Katherine M. Day, Jenna L. Bradner, Adrian J. Wolstenholme, Michael T. Dzimianski, Andrew R. Moorhead
Publikováno v:
Parasites & Vectors, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Background The American Heartworm Society currently recommends the use of a monthly macrocyclic lactone, a 28-day course of 10 mg/kg doxycycline BID, and the 3-dose protocol of melarsomine dihydrochloride for the treatment of canine heartwor
Externí odkaz:
https://doaj.org/article/98599aa6bd7941d496d5c54bdcd86b47
Autor:
Barbara J. Reaves, Connor Wallis, Ciaran J. McCoy, W. Walter Lorenz, Balazs Rada, Adrian J. Wolstenholme
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 587-595 (2018)
Mass administration of macrocyclic lactones targets the transmission of the causative agents of lymphatic filariasis to their insect vectors by rapidly clearing microfilariae (Mf) from the circulation. It has been proposed that the anti-filarial acti
Externí odkaz:
https://doaj.org/article/94e10d01df374f65935f8dd6f0a09d75
Autor:
Shivani Choudhary, Samuel K Buxton, Sreekanth Puttachary, Saurabh Verma, Gunnar R Mair, Ciaran J McCoy, Barbara J Reaves, Adrian J Wolstenholme, Richard J Martin, Alan P Robertson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008396 (2020)
Nematode parasites infect approximately 1.5 billion people globally and are a significant public health concern. There is an accepted need for new, more effective anthelmintic drugs. Nicotinic acetylcholine receptors on parasite nerve and somatic mus
Externí odkaz:
https://doaj.org/article/aaa14d3e9cdb433296675d4c9b44bba7
Autor:
Mary J. Maclean, Molly D. Savadelis, Ruby Coates, Michael T. Dzimianski, Corey Jones, Cynthia Benbow, Bobby E. Storey, Ray M. Kaplan, Andrew R. Moorhead, Adrian J. Wolstenholme
Publikováno v:
Parasites & Vectors, Vol 10, Iss S2, Pp 17-23 (2017)
Abstract Background Several reports have confirmed that macrocyclic lactone-resistant isolates of Dirofilaria immitis are circulating in the United States; however, the prevalence and potential impact of drug resistance is unknown. We wished to asses
Externí odkaz:
https://doaj.org/article/6b093c73862940b6a3696c9843a4e762
Publikováno v:
International Journal for Parasitology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::491a6334529ab6784fa76d91d73f1377
https://doi.org/10.1016/j.ijpara.2023.02.002
https://doi.org/10.1016/j.ijpara.2023.02.002