Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Adrian J Harwood"'
Autor:
Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood, Megan M. Jones, Lora Jones, Aishah Westwood, Olena Petter, Anthony R. Isles, David Linden, Marianne Van den Bree, Michael Owen, Jeremy Hall, Adrian J. Harwood
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Genetic evidence indicates disrupted epigenetic regulation as a major risk factor for psychiatric disorders, but the molecular mechanisms that drive this association remain to be determined. EHMT1 is an epigenetic repressor that is causal fo
Externí odkaz:
https://doaj.org/article/a29feaa54d654c329a44032677eee659
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/85b720dfc494491c993191ba7ab208f9
Autor:
Karolina Dec, Mouhamed Alsaqati, Joanne Morgan, Sumukh Deshpande, Jamie Wood, Jeremy Hall, Adrian J. Harwood
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: There is a growing interest in the possibility of dietary supplementation with polyunsaturated fatty acids (PUFAs) for treatment and prevention of neurodevelopmental and neuropsychiatric disorders. Studies have suggested that of the two
Externí odkaz:
https://doaj.org/article/41590c9c2cf149a2ae8ad9a7eae48718
Autor:
Jessica Robinson, Orhan Uzun, Ne Ron Loh, Isabelle Rose Harris, Thomas E. Woolley, Adrian J. Harwood, Jennifer Frances Gardner, Yasir Ahmed Syed
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Tuberous sclerosis complex (TSC) is a rare multi-system genetic disorder characterised by the presence of benign tumours throughout multiple organs including the brain, kidneys, heart, liver, eyes, lungs and skin, in addition to n
Externí odkaz:
https://doaj.org/article/8e4146c87a9044bc831f765b58d5b2ee
Autor:
Bret Sanders, Daniel D’Andrea, Mark O. Collins, Elliott Rees, Tom G. J. Steward, Ying Zhu, Gareth Chapman, Sophie E. Legge, Antonio F. Pardiñas, Adrian J. Harwood, William P. Gray, Michael C. O’Donovan, Michael J. Owen, Adam C. Errington, Derek J. Blake, Daniel J. Whitcomb, Andrew J. Pocklington, Eunju Shin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Coordinated programs of gene expression drive brain development. Here, the authors use human embryonic stem cells and foetal cortical tissue as well as available GWAS statistics and analysis of genetic variants associated with neuropsychiatric disord
Externí odkaz:
https://doaj.org/article/42f6d2253f3b4cb0a163dcbb417d1ba0
Autor:
Nicole Gruenheit, Amy Baldwin, Balint Stewart, Sarah Jaques, Thomas Keller, Katie Parkinson, William Salvidge, Robert Baines, Chris Brimson, Jason B. Wolf, Rex Chisholm, Adrian J. Harwood, Christopher R. L. Thompson
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-19 (2021)
Abstract Background Genomes can be sequenced with relative ease, but ascribing gene function remains a major challenge. Genetically tractable model systems are crucial to meet this challenge. One powerful model is the social amoeba Dictyostelium disc
Externí odkaz:
https://doaj.org/article/0a178d1a90004f409c83d0016a7cd7de
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-13 (2020)
Abstract Background Tuberous sclerosis complex (TSC) is a rare genetic multisystemic disorder resulting from autosomal dominant mutations in the TSC1 or TSC2 genes. It is characterised by hyperactivation of the mechanistic target of rapamycin complex
Externí odkaz:
https://doaj.org/article/2d5e00912a784374998241719343ff7e
Autor:
Danijela Drakulic, Srdjan Djurovic, Yasir Ahmed Syed, Sebastiano Trattaro, Nicolò Caporale, Anna Falk, Rivka Ofir, Vivi M. Heine, Samuel J. R. A. Chawner, Antonio Rodriguez-Moreno, Marianne B. M. van den Bree, Giuseppe Testa, Spyros Petrakis, Adrian J. Harwood
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020)
Abstract Patients diagnosed with chromosome microdeletions or duplications, known as copy number variants (CNVs), present a unique opportunity to investigate the relationship between patient genotype and cell phenotype. CNVs have high genetic penetra
Externí odkaz:
https://doaj.org/article/d4e8450a48824f23b625b697df32b39b
Autor:
Aishwarya G. Nadadhur, Mouhamed Alsaqati, Lisa Gasparotto, Paulien Cornelissen-Steijger, Eline van Hugte, Stephanie Dooves, Adrian J. Harwood, Vivi M. Heine
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 42-56 (2019)
Summary: Tuberous sclerosis complex (TSC) is a rare neurodevelopmental disorder resulting from autosomal dominant mutations in the TSC1 or TSC2 genes, leading to a hyperactivated mammalian target of rapamycin (mTOR) pathway, and gray and white matter
Externí odkaz:
https://doaj.org/article/03f59f6c7715412aa20eb66b5c45b209
Autor:
Sharna Lunn, Tanya Singh, Mouhamed Alsaqati, Michael J. Owen, Gareth Chapman, Jeremy Hall, David Edmund Johannes Linden, Marianne Bernadette van den Bree, Adrian J. Harwood, Stefanie C. Linden, Yasir Ahmed Syed, Mike Ziller
Publikováno v:
Molecular Psychiatry, 27(2), 819-830. Nature Publishing Group
Copy Number Variation (CNV) at the 1q21.1 locus is associated with a range of neurodevelopmental and psychiatric disorders in humans, including abnormalities in head size and motor deficits. Yet, the functional consequences of these CNVs (both deleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e82de91a3a5c009ec5e593cbee5efed
https://cris.maastrichtuniversity.nl/en/publications/0d414651-5a0c-4c60-bb17-4f0cc2038f20
https://cris.maastrichtuniversity.nl/en/publications/0d414651-5a0c-4c60-bb17-4f0cc2038f20