Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Adrian Härtsch"'
Autor:
F. Wieland Goetzke, Tobias Hüfner-Wulsdorf, François Diederich, Christoph Hohn, Klaus Reuter, F.R. Ehrmann, Maurice Sebastiani, Adrian Härtsch, E. Hassaan, Gerhard Klebe, Levon D. Movsisyan
Publikováno v:
Journal of Medicinal Chemistry, 63 (13)
Fragment-based lead discovery was applied to tRNA-guanine transglycosylase, an enzyme modifying post-transcriptionally tRNAs in Shigella, the causative agent of shigellosis. TGT inhibition prevents translation of Shigella's virulence factor VirF, hen
Autor:
Andreas Heine, Gerhard Klebe, M. Neeb, Christoph Hohn, Adrian Härtsch, François Diederich, F.R. Ehrmann
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:4900-4910
Small-molecule ligands binding with partial disorder or enhanced residual mobility are usually assumed as unfavorable with respect to their binding properties. Considering thermodynamics, disorder or residual mobility is entropically favorable and co
Autor:
Christoph Hohn, François Diederich, Nils Trapp, F.R. Ehrmann, Oliver Dumele, Gerhard Klebe, Adrian Härtsch, Toni Pfaffeneder
Publikováno v:
Chemistry - A European Journal. 22:6750-6754
Shigellosis is one of the most severe diarrheal diseases worldwide without any efficient treatment so far. The enzyme tRNA-guanine transglycosylase (TGT) has been identified as a promising target for small-molecule drug design. Herein, we report a tr