Výsledky vyhledávání - "Adrian G, Wright"

Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome

Autor: Trevor Morgan, Kazuyoshi Aso, Huilin Li, Wenhu Zhan, Gang Lin, Tierra Ouellette, Peter T. Meinke, Carl Nathan, Manoj K. Ramjee, Adrian G. Wright, Hao-Chi Hsu, Toshihiro Imaeda, Mayako Michino, Kenjiro Sato, Kristin Burns-Huang, Ryoma Hara, Michael Foley, Rei Okamoto

Publikováno v: Journal of Medicinal Chemistry. 62:9246-9253

Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Coevolving with its human host, Mycobacterium tuberculosis (Mtb) has developed mechanisms to resist host-impos...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04bac3c504e9295cab53b06b52750141
https://doi.org/10.1021/acs.jmedchem.9b01187

Zobrazit plný text záznamu

Selective Phenylimidazole-Based Inhibitors of the

Autor: Wenhu, Zhan, Hao-Chi, Hsu, Trevor, Morgan, Tierra, Ouellette, Kristin, Burns-Huang, Ryoma, Hara, Adrian G, Wright, Toshihiro, Imaeda, Rei, Okamoto, Kenjiro, Sato, Mayako, Michino, Manoj, Ramjee, Kazuyoshi, Aso, Peter T, Meinke, Michael, Foley, Carl F, Nathan, Huilin, Li, Gang, Lin

Publikováno v: J Med Chem

Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Co-evolving with its human host, Mycobacterium tuberculosis (Mtb) has developed mechanisms to resist host-imposed nitrosative and oxidative stresses. Genetic delet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e4a3f60ba4d118c2b4f33fb5910f8a8
https://pubmed.ncbi.nlm.nih.gov/31560200

Zobrazit plný text záznamu

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

Autor: Christopher N. Selway, Manoj K. Ramjee, Timothy M. Chapman, Adrian G. Wright, Kristian Birchall, Shishir M. Pant, Topi A. Tervonen, Gary J. Tarver, Amanda Mukonoweshuro, Bimbisar Desai, Juha Klefström

Publikováno v: Journal of medicinal chemistry. 61(10)

Hepsin is a membrane-anchored serine protease whose role in hepatocyte growth factor (HGF) signaling and epithelial integrity makes it a target of therapeutic interest in carcinogenesis and metastasis. Using an integrated design, synthesis, and scree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8612b89fa24e6b54283fb3b2f9ce1f5
https://pubmed.ncbi.nlm.nih.gov/29701962

Zobrazit plný text záznamu

Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

Autor: Christopher N. Selway, Bimbisar Desai, Adrian G. Wright, Gary J. Tarver, Werngard Czechtizky, Karen Dixon, Qixing Feng, Manoj K. Ramjee, David M. Parry, Juergen Dedio, Elizabeth Farrant, Thorsten Schmidt, Trevor Morgan

Publikováno v: ACS Medicinal Chemistry Letters. 4:768-772

A novel integrated discovery platform has been used to synthesize and biologically assay a series of xanthine-derived dipeptidyl peptidase 4 (DPP4) antagonists. Design, synthesis, purification, quantitation, dilution, and bioassay have all been fully

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bace8132944a627147abd3e1a0919fb8
https://doi.org/10.1021/ml400171b

Zobrazit plný text záznamu

A Parallel Micro Turbulent Flow Chromatography-Tandem Mass Spectrometry Method for the Analysis of a Pharmaceutical Compound in Plasma

Autor: Adrian G Wright, Christophe Chassaing, H. Stafford, J. Luckwell, A Edgington

Publikováno v: Chromatographia. 62:17-24

Turbulent flow chromatography coupled to tandem mass spectrometry (TFC-MS-MS) has been widely used within bioanalysis, because of the ability to inject directly neat biological samples with no prior pretreatment. TFC-MS-MS removes the need for time c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a359c692f0aea07c4241d98adf30ba6
https://doi.org/10.1365/s10337-005-0562-3

Zobrazit plný text záznamu

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Autor: Dieter Verzele, Frederic Lynen, Pat Sandra, Melissa Hanna-Brown, Adrian G Wright, Mike De Vrieze

Publikováno v: Chem. Commun.. 48:1162-1164

A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1a33b82fdbbb8a1bae9364525674f1
https://doi.org/10.1039/c2cc16872c

Zobrazit plný text záznamu

Open access capillary electrophoresis

Autor: Gorkhn Sharma-Singh, Frank S. Pullen, David A. Brown, Adrian G Wright

Publikováno v: Journal of Chromatography A. 888:219-227

A capillary electrophoresis (CE) system has been developed to provide routine purity information to support synthetic organic chemists. A single micellar electrokinetic chromatography system that produces good selectivity with short run times was dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d1e2e22588161308dc4f56656dd6d95
https://doi.org/10.1016/s0021-9673(00)00550-1

Zobrazit plný text záznamu

Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform

Autor: Gary J. Tarver, Adrian G. Wright, Trevor Morgan, Qixing Feng, Elizabeth Farrant, Manoj K. Ramjee, Karen Dixon, David M. Parry, Christopher N. Selway, Willem P. van Hoorn, Bimbisar Desai, Gavin A. Whitlock, Karl Richard Gibson, James Edward John Mills

Publikováno v: Journal of medicinal chemistry. 56(7)

Drug discovery faces economic and scientific imperatives to deliver lead molecules rapidly and efficiently. Using traditional paradigms the molecular design, synthesis, and screening loops enforce a significant time delay leading to inefficient use o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37c1c3b131c69733dd8ddcd1ae9f984
https://pubmed.ncbi.nlm.nih.gov/23441572

Zobrazit plný text záznamu

Thermoresponsive poly(N-vinylcaprolactam) as stationary phase for aqueous and green liquid chromatography

Autor: Adrian G Wright, Melvin R. Euerby, Pat Sandra, Frederic Lynen, Bram Miserez

Publikováno v: CHROMATOGRAPHIA

Poly(N-vinylcaprolactam) (PVCL) connected to aminopropyl silica is a new stationary phase for temperature responsive liquid chromatography (TR-LC). PVCL shows a transition from hydrophilic to hydrophobic interaction between 30 and 40 degrees C. The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04cdc52028d672ba953ea700efba87e
https://hdl.handle.net/1854/LU-888915

Zobrazit plný text záznamu

Application of parallel gradient high performance liquid chromatography with ultra-violet, evaporative light scattering and electrospray mass spectrometric detection for the quantitative quality control of the compound file to support pharmaceutical discovery

Autor: Adrian G Wright, Peter Waghorn, Anthony W. Squibb, Barry L. Parnas, Mark R. Taylor, Gareth P. Williams, Frank S. Pullen, Richard Girdler

Publikováno v: Journal of chromatography. A. 1189(1-2)

The success of drug discovery assays, using plate-based technologies, relies heavily on the quality of the substrates being tested. Sample purity, identity and concentration must be assured for a screening hit to be validated. Most major pharmaceutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2153ab9c7ccb5efa01ab97f1a7930cc9
https://pubmed.ncbi.nlm.nih.gov/18061198

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání