Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adrian Funke"'
Autor:
Alexander Ryckaert, Michael Ghijs, Christoph Portier, Dejan Djuric, Adrian Funke, Chris Vervaet, Thomas De Beer
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 293 (2021)
The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules b
Externí odkaz:
https://doaj.org/article/5cf6e50eafa74b3293cc26591d804f2b
Autor:
Valérie Vanhoorne, D. Van Hauwermeiren, Dejan Djuric, Adrian Funke, Chris Vervaet, Alexander Ryckaert, Ingmar Nopens, T. De Beer, F. Stauffer
Publikováno v:
International journal of pharmaceutics. 584
Wetting is the initial stage of wet granulation processes during which the first contact between the powder and the liquid occurs. Wetting is a critical step to allow granule growth and consolidation, but also to ensure uniform active pharmaceutical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679247bb0cf4d9f789ed7bda44619b17
https://pubmed.ncbi.nlm.nih.gov/32454132
https://pubmed.ncbi.nlm.nih.gov/32454132
Autor:
Theresa Hörmann, Adrian Funke, Reinhardt-Karsten Mürb, Johannes Khinast, Amrit Paudel, Nina Jäger
Publikováno v:
International Journal of Pharmaceutics. 553:408-421
This work evaluates several compositions of an amorphous solid dispersion (ASD) comprising nimodipine (NMD) as poorly soluble model API in a dual-polymer carrier system. HPMC E5 and Eudragit E were used for the two polymeric carriers. The formulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9675bc9bb232d90d0ff5e685bd37af5
https://doi.org/10.1016/j.ijpharm.2018.10.035
https://doi.org/10.1016/j.ijpharm.2018.10.035
Autor:
T. De Beer, Jens Dhondt, Dejan Djuric, Ingmar Nopens, D. Van Hauwermeiren, Alexander Ryckaert, A. De Man, Adrian Funke, Chris Vervaet
Publikováno v:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
In recent years, the interest in continuous manufacturing techniques, such as twin-screw wet granulation, has increased. However, the understanding of the influence of the combination of raw material properties and process settings upon the granule q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f2aaaad1b0692491167b63082a6472
https://doi.org/10.1016/j.ijpharm.2021.120785
https://doi.org/10.1016/j.ijpharm.2021.120785
Autor:
Stephan Laske, Amrit Paudel, Otto Scheibelhofer, Stephan Sacher, Theresa Hoermann, Johannes Khinast, Adrian Kelly, Jukka Rantannen, Ossi Korhonen, Fanny Stauffer, Fien De Leersnyder, Thomas De Beer, Jerome Mantanus, Pierre-Francois Chavez, Benjamin Thoorens, Patrizia Ghiotti, Martin Schubert, Pirjo Tajarobi, Gunnar Haeffler, Satu Lakio, Magnus Fransson, Anders Sparen, Susanna Abrahmsen-Alami, Staffan Folestad, Adrian Funke, Ivo Backx, Barbara Kavsek, Francois Kjell, Marc Michaelis, Trevor Page, John Palmer, Alexander Schaepman, Sonja Sekulic, Steve Hammond, Birgit Braun, Brenda Colegrove
Publikováno v:
Journal of Pharmaceutical Sciences. 106:667-712
Pharmaceutical solid oral dosage product manufacturing is a well-established, yet revolutionizing area. To this end, process analytical technology (PAT) involves interdisciplinary and multivariate (chemical, physical, microbiological, and mathematica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993fd1ca3ced0d4bd0f3956bcb28ea3d
https://doi.org/10.1016/j.xphs.2016.11.011
https://doi.org/10.1016/j.xphs.2016.11.011
Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding
Autor:
Ingmar Nopens, Thomas De Beer, Daan Van Hauwermeiren, F. Stauffer, Dejan Djuric, Adrian Funke, Alexander Ryckaert
Publikováno v:
AAPS PharmSciTech. 20
During the last decade, the pharmaceutical industry has shown a growing interest in continuous twin-screw granulation (TSG). Despite flourishing literature on TSG, limited studies focused on fundamental process understanding on its mechanisms. In cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883d0015d5ac9cd32bc38a402641943f
https://doi.org/10.1208/s12249-019-1483-z
https://doi.org/10.1208/s12249-019-1483-z
Autor:
C. Makert, L.-M. Schaden, O. Scheibelhofer, Johannes Khinast, Adrian Funke, Thomas Hörmann, Jakob Rehrl
Publikováno v:
International journal of pharmaceutics. 566
The purpose of this work was to develop a robust hot-melt extrusion and strand pelletization process for manufacturing pellets with an immediate release (IR) of a poorly water-soluble active pharmaceutical ingredient (API), nimodipine. The robustness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619741c9857176f7e80748877a46fb1c
https://pubmed.ncbi.nlm.nih.gov/31103818
https://pubmed.ncbi.nlm.nih.gov/31103818
Autor:
Chris Vervaet, Christoph Portier, Dejan Djuric, Alexander Ryckaert, Thomas De Beer, Michael Ghijs, Adrian Funke
Publikováno v:
Pharmaceutics, Vol 13, Iss 293, p 293 (2021)
Pharmaceutics
Volume 13
Issue 2
PHARMACEUTICS
Pharmaceutics
Volume 13
Issue 2
PHARMACEUTICS
The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4638972edff435a59f6dfd72c80d4fc2
https://doi.org/10.3390/pharmaceutics13020293
https://doi.org/10.3390/pharmaceutics13020293
Autor:
Andreas Altmeyer, Klaus Knop, Peter Kleinebudde, Johannes Khinast, Rok Dreu, Adrian Funke, Gregor Toschkoff
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 106:97-106
The tablet pan coating process involves various types of transverse tablet bed motions, ranging from rolling to cascading. To preserve satisfactory results in terms of coating quality after scale-up, understanding the dynamics of pan coating process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad866f2fcb0b38a41035f51d2fd10c59
https://doi.org/10.1016/j.ejpb.2016.05.022
https://doi.org/10.1016/j.ejpb.2016.05.022
Autor:
Gregor Toschkoff, Klaus Knop, Johannes Khinast, Georg Scharrer, Dejan Djuric, Peter Kleinebudde, Sarah Just, Adrian Funke
Publikováno v:
International Journal of Pharmaceutics. 457:1-8
The objective of this study was to enhance the inter-tablet coating uniformity in an active coating process at lab and pilot scale by statistical design of experiments. The API candesartan cilexetil was applied onto gastrointestinal therapeutic syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b819684bb60decae35e7d7f0c9649797
https://doi.org/10.1016/j.ijpharm.2013.09.010
https://doi.org/10.1016/j.ijpharm.2013.09.010