Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Adrian Fowkes"'
Publikováno v:
Current Research in Toxicology, Vol 5, Iss , Pp 100124- (2023)
Integrated approaches to testing and assessments (IATAs) have been proposed as a method to organise new approach methodologies in order to replace traditional animal testing for chemical safety assessments. To capture the mechanistic aspects of toxic
Externí odkaz:
https://doaj.org/article/09e1b1b6506a456faa670334abe7c064
Autor:
Robert S. Foster, Adrian Fowkes, Alex Cayley, Andrew Thresher, Anne-Laure D. Werner, Chris G. Barber, Grace Kocks, Rachael E. Tennant, Richard V. Williams, Steven Kane, Susanne A. Stalford
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-9 (2020)
Abstract The use of in silico predictions for the assessment of bacterial mutagenicity under the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline is recommended when two complement
Externí odkaz:
https://doaj.org/article/1833385354894e5fa7b556bfdcbab733
Autor:
Adrian Fowkes, Robert Foster, Steven Kane, Andrew Thresher, Anne-Laure Werner, Antonio Anax F. de Oliveira
Publikováno v:
Toxicology mechanisms and methods.
Toxicity safety assessments are a fundamental part of the lifecycle of products and aim to protect human health and the environment from harmful exposures to chemical substances. To make decisions regarding the suitability of testing strategies, the
Autor:
Robert Foster, Adrian Fowkes, Barber Christopher Gordon, Susanne A. Stalford, Emma Hill, Alex Cayley, Artur Polit, Martyn L. Chilton, Jonathan D. Vessey, Crina Heghes, Donna S. Macmillan, Steven Kane, Alun Myden, Natasha T. Hill, Daniel A. Newman, Thomas Ball
Publikováno v:
Toxicology Research
Adverse outcome pathways have shown themselves to be useful ways of understanding and expressing knowledge about sequences of events that lead to adverse outcomes (AOs) such as toxicity. In this paper we use the building blocks of adverse outcome pat
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 108
The development and application of (quantitative) structure-activity relationship ((Q)SAR) models for reproductive toxicology remains challenging, given the complexity of the endpoint and the risks associated with subsequent decision making. Adverse
Autor:
Grace Kocks, Steven Kane, Susanne A. Stalford, Rachael E. Tennant, Andrew Thresher, Robert Foster, Anne-Laure D. Werner, Adrian Fowkes, Alex Cayley, Richard V. Williams, Barber Christopher Gordon
Publikováno v:
Genes and Environment
Genes and Environment, Vol 42, Iss 1, Pp 1-9 (2020)
Genes and Environment, Vol 42, Iss 1, Pp 1-9 (2020)
The use of in silico predictions for the assessment of bacterial mutagenicity under the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline is recommended when two complementary (quan
Autor:
Adrian Fowkes, A. Caley, Steven Kane, Daniel A. Newman, G Kocks, Jonathan D. Vessey, S.A. Stalford, Emma Hill, Robert Foster, Alun Myden, A.A. Oliveira
Publikováno v:
Toxicology Letters. 350:S46
Publikováno v:
Mutagenesis. 34(1)
While high-level performance metrics generated from the validation of quantitative structure-activity relationship (QSAR) systems can provide valuable information on how well these models perform and where they need to be improved, they require appro
Autor:
Geoff Wells, Hélène Bertrand, Albena T. Dinkova-Kostova, Clarisse Thiollier, Nikolaos D. Georgakopoulos, Adrian Fowkes, Liam Baird, Hiroko Kachi, Marjolein Schaap
Publikováno v:
Journal of Medicinal Chemistry. 58:7186-7194
The transcription factor Nrf2 regulates the expression of a large network of cytoprotective and metabolic enzymes and proteins. Compounds that directly and reversibly inhibit the interaction between Nrf2 and its main negative regulator Keap1 are pote
Autor:
Geoff Wells, Adrian Fowkes
Publikováno v:
Fluorinated Pharmaceuticals: Advances in Medicinal Chemistry. :18-29
© 2015 Future Science Ltd. Fluorinated amino acid analogs can be used as enzyme inhibitors, to apply conformational restraints and to modulate the pKa of ionizable groups.