Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Adrian Fabisiak"'
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Akademický článek
Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey
Autor: Tae-Kang Kim, Venkatram Atigadda, Pawel Brzeminski, Adrian Fabisiak, Edith K. Y. Tang, Robert C. Tuckey, Andrzej T. Slominski
Publikováno v: Molecules, Vol 25, Iss 11, p 2583 (2020)
20(S)-Hydroxyvitamin D3 (20(OH)D3) is an endogenous metabolite produced by the action of CYP11A1 on the side chain of vitamin D3 (D3). 20(OH)D3 can be further hydroxylated by CYP11A1, CYP27A1, CYP24A1 and/or CYP27B1 to several hydroxyderivatives. CYP
Externí odkaz: https://doaj.org/article/7b8cb16eafeb4353bb7f2cf2744c8af2
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2
Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey
Autor: Andrzej T Slominski, Russel J Reiter, Pawel Brzeminski, Adrian Fabisiak, Tae-Kang Kim
Publikováno v: Melatonin Research. 5:374-380
We are commenting recent discoveries on the presence of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK and AMK in honey. Serotonin and melatonin, products of the tryptophan metabol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94309a5d66369223d24cef96131777d6
https://doi.org/10.32794/mr112500137
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4
Detection of Serotonin, Melatonin, and Their Metabolites in Honey
Autor: Tae Kang Kim, Venkatram R. Atigadda, Russel J. Reiter, Edith K.Y. Tang, Robert C. Tuckey, Pawel Brzeminski, Andrzej Slominski, Adrian Fabisiak
Publikováno v: ACS Food Sci Technol
Melatonin and serotonin, products of tryptophan metabolism, are endogenous neurotransmitters and hormones. We have identified and quantified these metabolites in natural honey from Australia, USA, and Poland using a Xevo G2 XS qTof LC–MS. To help e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00c44823641becffe2772a3e7982de0
https://pubmed.ncbi.nlm.nih.gov/35449872
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5
Novel superagonist analogs of 2-methylene calcitriol: Design, molecular docking, synthesis and biological evaluation
Autor: Adrian Fabisiak, Hector F. DeLuca, Pawel Brzeminski, Izabela K. Sibilska-Kaminski, Lori A. Plum, Rafal R. Sicinski
Publikováno v: Bioorganic chemistry. 118
A new series of highly biologically active (20S,22R)-1α,25-dihydroxy-22-methyl- 2-methylene-vitamin D3 analogs, possessing different side chains, have been efficiently prepared as potential agents for medical therapy. Design of these synthetic targe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021142f48d1ec77ec5fea729ad1fee0a
https://pubmed.ncbi.nlm.nih.gov/34798456
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6
Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D
Autor: Pawel, Brzeminski, Adrian, Fabisiak, Radomir M, Slominski, Tae-Kang, Kim, Zorica, Janjetovic, Ewa, Podgorska, Yuwei, Song, Mohammad, Saleem, Sivani B, Reddy, Shariq, Qayyum, Yuhua, Song, Robert C, Tuckey, Venkatram, Atigadda, Anton M, Jetten, Rafal R, Sicinski, Chander, Raman, Andrzej T, Slominski
Publikováno v: Bioorg Chem
New and more efficient routes of chemical synthesis of vitamin D(3) (D(3)) hydroxy (OH) metabolites, including 20S(OH)D(3), 20S,23S(OH)(2)D(3) and 20S,25(OH)(2)D(3), that are endogenously produced in the human body by CYP11A1, and of 20S,23R(OH)(2)D(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b538e5da852cfe6389176217f51e03bc
https://pubmed.ncbi.nlm.nih.gov/35168121
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7
RF15 | PMON293 Metabolic activation of tachysterol to biologically active hydroxyderivatives that act on VDR, AhR, LXRs and PPARγ receptors
Autor: Andrzej Slominski, Tae-Kang Kim, Radomir Slominski, Yuwei Song, Zorica Janjetovic, Ewa Podgorska, Sivani Reddy, Yuhua Song, Chander Raman, Edith Tang, Adrian Fabisiak, Pawel Brzeminski, Rafal Sicinski, Venkatram Atigadda, Anton Jetten, Michael Holick, Robert Tuckey
Publikováno v: Journal of the Endocrine Society. 6:A734-A734
Absorption of ultraviolet B (UVB) radiation by the B ring of 7-dehydrocholesterol (7-DHC) leads to the transformation of 7-DHC to previtamin D3, which after absorption of additional UVB isomerizes to tachysterol3 (T3) and lumisterol3 (L3). Previously
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::117743f1f502eb607ef8d2bbbb687609
https://doi.org/10.1210/jendso/bvac150.1515
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9
Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs
Autor: Pawel Brzeminski, Lucie Rárová, Rafal R. Sicinski, Ewa Marcinkowska, Adrian Fabisiak, Klaudia Berkowska
Publikováno v: Bioorganic chemistry. 101
Continuing our studies aimed at A-ring modified vitamin D compounds, we designed novel 19-norcalcitriol derivatives bearing at C-2 pegylated chains of different lengths. The terminal fragments of these substituents contain hydroxyls or moieties posse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199b145f4413b6ce7f8edeb1edfa52b1
https://pubmed.ncbi.nlm.nih.gov/32629275
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10
Synthesis of Gemini analogs of 19-norcalcitriol and their platinum(II) complexes
Autor: Rafal R. Sicinski, Adrian Fabisiak, Lucie Rárová, Pawel Brzeminski, Klaudia Berkowska, Ewa Marcinkowska
Publikováno v: Bioorganic chemistry. 100
Hormonally active vitamin D3 metabolite, calcitriol, plays an important role in calcium-phosphate homeostasis, immune system actions and cell differentiation. Although anticancer activity of calcitriol is well documented and thousands of its analogs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3df298b031e819d87ac3bd15fc7b678
https://pubmed.ncbi.nlm.nih.gov/32361296
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