Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine

Autor: Adrian F. Sagebiel, Fenja Steinert, Sebastian Lunemann, Christian Körner, Renée R. C. E. Schreurs, Marcus Altfeld, Daniel Perez, Konrad Reinshagen, Madeleine J. Bunders

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Innate lymphoid cells (ILC), including natural killer (NK) cells, are important innate immune regulators. Here the authors show that, in human infant intestines, CD103+Eomes+ NK cells are the predominant ILC population, but are replaced gradually by

Externí odkaz: https://doaj.org/article/df407d747ae34b6e86a1aa8b20d600bd

CXCR5

Autor: Ana, Jordan-Paiz, Glòria, Martrus, Fenja L, Steinert, Max, Kaufmann, Adrian F, Sagebiel, Renée R C E, Schreurs, Anne, Rechtien, Martin E, Baumdick, Johannes M, Jung, Kimberly J, Möller, Lucy, Wegner, Cordula, Grüttner, Laura, Richert, Roland, Thünauer, Jennifer, Schroeder-Schwarz, Johannes B, van Goudoever, Teunis B H, Geijtenbeek, Marcus, Altfeld, Steven T, Pals, Daniel, Perez, Paul L, Klarenbeek, Christian, Tomuschat, Guido, Sauter, Ingo, Königs, Udo, Schumacher, Manuel A, Friese, Nathaniel, Melling, Konrad, Reinshagen, Madeleine J, Bunders

Publikováno v: Cellularmolecular immunology.

Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::892631d60396a12f1919895e2a417626
https://pubmed.ncbi.nlm.nih.gov/36600048

Tissue-resident Eomes

Autor: Adrian F, Sagebiel, Fenja, Steinert, Sebastian, Lunemann, Christian, Körner, Renée R C E, Schreurs, Marcus, Altfeld, Daniel, Perez, Konrad, Reinshagen, Madeleine J, Bunders

Publikováno v: Nature Communications

Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31bb5558e7252db37f6678ae311efbf4
https://pubmed.ncbi.nlm.nih.gov/30816112

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Autor: Renée R.C.E. Schreurs, Martin E. Baumdick, Adrian F. Sagebiel, Max Kaufmann, Michal Mokry, Paul L. Klarenbeek, Nicola Schaltenberg, Fenja L. Steinert, Jorik M. van Rijn, Agata Drewniak, Sarah-May M.L. The, Roel Bakx, Joep P.M. Derikx, Niek de Vries, Willemijn E. Corpeleijn, Steven T. Pals, Nicola Gagliani, Manuel A. Friese, Sabine Middendorp, Edward E.S. Nieuwenhuis, Konrad Reinshagen, Teunis B.H. Geijtenbeek, Johannes B. van Goudoever, Madeleine J. Bunders

Publikováno v: Immunity
Schreurs, R R C E, Baumdick, M E, Sagebiel, A F, Kaufmann, M, Mokry, M, Klarenbeek, P L, Schaltenberg, N, Steinert, F L, van Rijn, J M, Drewniak, A, The, S-M M L, Bakx, R, Derikx, J P M, de Vries, N, Corpeleijn, W E, Pals, S T, Gagliani, N, Friese, M A, Middendorp, S, Nieuwenhuis, E E S, Reinshagen, K, Geijtenbeek, T B H, van Goudoever, J B & Bunders, M J 2019, ' Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life ', Immunity, vol. 50, no. 2, pp. 462-476.e8 . https://doi.org/10.1016/j.immuni.2018.12.010
Immunity, 50(2), 462-476.e8. Cell Press
Immunity, 50(2), 462. Cell Press

Although the fetal immune system is considered tolerogenic, preterm infants can suffer from severe intestinal inflammation, including necrotizing enterocolitis (NEC). Here, we demonstrate that human fetal intestines predominantly contain tumor necros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165eee5986f2839a75afb32d37fd2bef
https://doi.org/10.1016/j.immuni.2018.12.010