Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Adrian D. Bonev"'
Autor:
Anne E. Turco, Steven R. Oakes, Kimberly P. Keil Stietz, Cheryl L. Dunham, Diya B. Joseph, Thrishna S. Chathurvedula, Nicholas M. Girardi, Andrew J. Schneider, Joseph Gawdzik, Celeste M. Sheftel, Peiqing Wang, Zunyi Wang, Dale E. Bjorling, William A. Ricke, Weiping Tang, Laura L. Hernandez, Janet R. Keast, Adrian D. Bonev, Matthew D. Grimes, Douglas W. Strand, Nathan R. Tykocki, Robyn L. Tanguay, Richard E. Peterson, Chad M. Vezina
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 7 (2021)
Benign prostatic hyperplasia/lower urinary tract dysfunction (LUTD) affects nearly all men. Symptoms typically present in the fifth or sixth decade and progressively worsen over the remainder of life. Here, we identify a surprising origin of this dis
Externí odkaz:
https://doaj.org/article/4952606b90dc471c92b6828b628113c4
Autor:
Maria Sancho, Nicholas R. Klug, Amreen Mughal, Masayo Koide, Saul Huerta de la Cruz, Thomas J. Heppner, Adrian D. Bonev, David Hill-Eubanks, Mark T. Nelson
Publikováno v:
Sci Signal
The dense network of capillaries composed of capillary endothelial cells (cECs) and pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron- and glial-derived compounds that enhance regional and global cerebral perfus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3454ce1c75f0c8fb2383cf7f7d31555e
https://europepmc.org/articles/PMC9623876/
https://europepmc.org/articles/PMC9623876/
Autor:
Mark T. Nelson, Kalev Freeman, Nuria Villalba, Osama F. Harraz, Adrian M. Sackheim, Travis Nemkov, Adrian D. Bonev, Angelo D'Alessandro, Maria Sancho
Publikováno v:
Function (Oxf)
Trauma can lead to widespread vascular dysfunction, but the underlying mechanisms remain largely unknown. Inward-rectifier potassium channels (Kir2.1) play a critical role in the dynamic regulation of regional perfusion and blood flow. Kir2.1 channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073f6cb1c1aa0f534e6e0d2aa9ed378d
https://pubmed.ncbi.nlm.nih.gov/35330675
https://pubmed.ncbi.nlm.nih.gov/35330675
Autor:
Nathan R. Tykocki, Cheryl L. Dunham, Nicholas M Girardi, Celeste M Sheftel, Janet R. Keast, Diya B. Joseph, Dale E. Bjorling, Laura L. Hernandez, Anne E. Turco, Chad M. Vezina, Matthew D Grimes, Weiping Tang, Thrishna S Chathurvedula, Douglas W. Strand, Peiqing Wang, Kimberly P. Keil Stietz, Steven R Oakes, William A. Ricke, Richard E. Peterson, Adrian D. Bonev, Robyn L Tanguay, Joseph Gawdzik, Andrew J. Schneider, Zunyi Wang
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 7 (2021)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 7 (2021)
Benign prostatic hyperplasia/lower urinary tract dysfunction (LUTD) affects nearly all men. Symptoms typically present in the fifth or sixth decade and progressively worsen over the remainder of life. Here, we identify a surprising origin of this dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cddbb3ff04b6700dfbc50089b89531
http://europepmc.org/articles/PMC8326766
http://europepmc.org/articles/PMC8326766
Autor:
Jesse Moore, Shaun Reining, Michael I. Kotlikoff, Bo Shui, Mark T. Nelson, Zachary D. Miller, Frank K. Lee, Nuria Villalba, Adrian D. Bonev, Kalev Freeman, Daniel M. Collier, Jane C. Lee, Adrian M. Sackheim
Publikováno v:
Am J Physiol Heart Circ Physiol
Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a mechanism suspected to involve en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38894a4176e752f076d0ee5c2cdd72b
https://doi.org/10.1152/ajpheart.00655.2018
https://doi.org/10.1152/ajpheart.00655.2018
Autor:
Kalev Freeman, Mark T. Nelson, Maria Sancho, Angelo D'Alessandro, Adrian D. Bonev, Adrian M. Sackheim, Travis Nemkov, Osama F. Harraz, Nuria Villalba
BACKGROUND AND PURPOSETrauma can lead to widespread vascular endothelial dysfunction, but the underlying mechanisms remain largely unknown. Strong inward-rectifier potassium channels (Kir2.1) play a critical role in the dynamic regulation of regional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::754ffa8da2fcea7a48a3484f4541c07f
https://doi.org/10.1101/2021.01.15.426853
https://doi.org/10.1101/2021.01.15.426853
Autor:
Jessica L. Sheehe, Mark T. Nelson, Adrian D. Bonev, Anna M. Schmoker, Wolfgang R. Dostmann, Bryan A. Ballif, Thomas M. Moon
Publikováno v:
Journal of Biological Chemistry. 293:16791-16802
The type I cGMP-dependent protein kinase (PKG I) is an essential regulator of vascular tone. It has been demonstrated that the type Iα isoform can be constitutively activated by oxidizing conditions. However, the amino acid residues implicated in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15626f23bfa5be5a2a0100ce07d626fd
https://doi.org/10.1074/jbc.ra118.004363
https://doi.org/10.1074/jbc.ra118.004363
Publikováno v:
Tykocki, N R, Bonev, A D, Longden, T A, Heppner, T J & Nelson, M T 2017, ' Inhibition of vascular smooth muscle inward-rectifier K + channels restores myogenic tone in mouse urinary bladder arterioles ', American Journal of Physiology: Renal Physiology, vol. 312, no. 5, pp. F836-F847 . https://doi.org/10.1152/ajprenal.00682.2016
Prolonged decreases in urinary bladder blood flow are linked to overactive and underactive bladder pathologies. However, the mechanisms regulating bladder vascular reactivity are largely unknown. To investigate these mechanisms, we examined myogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d848e487da5539ed3f6052994098e16
https://doi.org/10.1152/ajprenal.00682.2016
https://doi.org/10.1152/ajprenal.00682.2016
Autor:
Adrian D. Bonev, Mark T. Nelson, Gro Klitgaard Povlsen, Thomas A Longden, David C. Hill-Eubanks
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Transient global cerebral ischemia is often followed by delayed disturbances of cerebral blood flow, contributing to neuronal injury. The pathophysiological processes underlying such disturbances are incompletely understood. Here, using an establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d15b35d07ae1882d51eb6908a09db92
https://doi.org/10.1177/0271678x16638350
https://doi.org/10.1177/0271678x16638350
Publikováno v:
The Journal of Physiology. 594:3271-3285
Key points Increase in endothelial cell (EC) calcium activates calcium-sensitive intermediate and small conductance potassium (IK and SK) channels, thereby causing hyperpolarization and endothelium-dependent vasodilatation. Endothelial cells express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::883676c259ab0fa0022050d406ae551c
https://doi.org/10.1113/jp271652
https://doi.org/10.1113/jp271652