Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adrian D, Hobson"'
Autor:
Adrian D. Hobson, Michael J. McPherson, Martin E. Hayes, Christian Goess, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Jindong Yang, Liang Sun, Qiang Zhang, Pei Qu, Shi Yang, Axel Hernandez, Shaughn H. Bryant, Suzanne L. Mathieu, Agnieszka K. Bischoff, Julia Fitzgibbons, Ling C. Santora, Lu Wang, Margaret M. Fettis, Xiaofeng Li, Christopher C. Marvin, Zhi Wang, Meena V. Patel, Diana L. Schmidt, Tongmei Li, John T. Randolph, Rodger F. Henry, Candace Graff, Yu Tian, Ana L. Aguirre, Anurupa Shrestha
Publikováno v:
Journal of Medicinal Chemistry. 65:15893-15934
Using a convergent synthetic route to enable multiple points of diversity, a series of glucocorticoid receptor modulators (GRM) were profiled for potency, selectivity, and drug-like properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaa7289b2011ffa6a540288e003c12a
https://doi.org/10.1021/acs.jmedchem.2c01579
https://doi.org/10.1021/acs.jmedchem.2c01579
Autor:
Adrian D. Hobson, Michael J. McPherson, Wendy Waegell, Christian A. Goess, Robert H. Stoffel, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Axel Hernandez, Shaughn H. Bryant, Suzanne L. Mathieu, Agnieszka K. Bischoff, Julia Fitzgibbons, Martyna Pawlikowska, Sujiet Puthenveetil, Ling C. Santora, Lu Wang, Christopher C. Marvin, Martin E. Hayes, Anurupa Shrestha, Kathy A. Sarris, Biqin Li
Publikováno v:
Journal of Medicinal Chemistry. 66:6011-6011
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87de5b8b24454e72d2401dd3dabc79dd
https://doi.org/10.1021/acs.jmedchem.3c00598
https://doi.org/10.1021/acs.jmedchem.3c00598
Autor:
Adrian D. Hobson, Michael J. McPherson, Martin E. Hayes, Christian Goess, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Jindong Yang, Liang Sun, Qiang Zhang, Pei Qu, Shi Yang, Axel Hernandez, Shaughn H. Bryant, Suzanne L. Mathieu, Agnieszka K. Bischoff, Julia Fitzgibbons, Ling C. Santora, Lu Wang, Margaret M. Fettis, Xiaofeng Li, Christopher C. Marvin, Zhi Wang, Meena V. Patel, Diana L. Schmidt, Tongmei Li, John T. Randolph, Rodger F. Henry, Candace Graff, Yu Tian, Ana L. Aguirre, Anurupa Shrestha
Publikováno v:
Journal of Medicinal Chemistry. 66:6010-6010
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff450fedea2d580153f040ae31c6496
https://doi.org/10.1021/acs.jmedchem.3c00494
https://doi.org/10.1021/acs.jmedchem.3c00494
Autor:
Kathy Sarris, Philip J. Hajduk, Ihle David C, Diana L. Donnelly-Roberts, Arthur Gomtsyan, Christian Goess, David B. Duignan, Danying Song, Chaohong Sun, Andrea Mcclure, Adrian D. Hobson, Robert H. Stoffel, Anil Vasudevan, John A. Mankovich, Sanjay C. Panchal, A. Chris Krueger, Steven L. Swann, Kenneth M. Comess, Andrew M. Petros, Wilson Noel S, Jill M. Wetter, Paul G. Richardson, Kenton L. Longenecker, Paul M. Jung, Vincent S. Stoll, Amanda W. Dombrowski, Suzanne Mathieu, Justin D. Dietrich, Philip B. Cox
Publikováno v:
Journal of Medicinal Chemistry. 64:417-429
Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biologic drugs that inhibit TNFα has led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbe3ede703ddd1435f27709b6c8281
https://doi.org/10.1021/acs.jmedchem.0c01280
https://doi.org/10.1021/acs.jmedchem.0c01280
Autor:
Adrian D. Hobson, Michael J. McPherson, Wendy Waegell, Christian A. Goess, Robert H. Stoffel, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Axel Hernandez, Shaughn H. Bryant, Suzanne L. Mathieu, Agnieszka K. Bischoff, Julia Fitzgibbons, Martyna Pawlikowska, Sujiet Puthenveetil, Ling C. Santora, Lu Wang, Christopher C. Marvin, Martin E. Hayes, Anurupa Shrestha, Kathy A. Sarris, Biqin Li
Publikováno v:
Journal of medicinal chemistry. 65(6)
Glucocorticoid receptor modulators (GRM) are the first-line treatment for many immune diseases, but unwanted side effects restrict chronic dosing. However, targeted delivery of a GRM payload via an immunology antibody-drug conjugate (iADC) may delive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b933fac9976cb8ac1cf5fa1d56a1fbe
https://pubmed.ncbi.nlm.nih.gov/35133822
https://pubmed.ncbi.nlm.nih.gov/35133822
Autor:
Adrian D. Hobson, Russell A. Judge, Ana L. Aguirre, Brian S. Brown, Yifang Cui, Ping Ding, Eric Dominguez, Enrico DiGiammarino, David A. Egan, Gail M. Freiberg, Sujatha M. Gopalakrishnan, Christopher M. Harris, Marie P. Honore, Karen L. Kage, Nicolas J. Kapecki, Christopher Ling, Junli Ma, Helmut Mack, Mulugeta Mamo, Stefan Maurus, Bradford McRae, Nigel S. Moore, Bernhard K. Mueller, Reinhold Mueller, Marian T. Namovic, Kaushal Patel, Steve D. Pratt, C. Brent Putman, Kara L. Queeney, Kathy K. Sarris, Lisa M. Schaffter, Vincent Stoll, Anil Vasudevan, Lei Wang, Lu Wang, William Wirthl, Kimberly Yach
Publikováno v:
Journal of Medicinal Chemistry. 61:11074-11100
A HTS campaign identified compound 1, an excellent hit-like molecule to initiate medicinal chemistry efforts to optimize a dual ROCK1 and ROCK2 inhibitor. Substitution (2-Cl, 2-NH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba127f0c7da3013553a7215d8180f4bd
https://doi.org/10.1021/acs.jmedchem.8b01098
https://doi.org/10.1021/acs.jmedchem.8b01098
Autor:
Victoria E. Scott, Mulugeta Mamo, Russell A. Judge, Connie R. Faltynek, C. Brent Putman, Ana L. Aguirre, Marian Namovic, Vincent S. Stoll, Karen Kage, Steven Cassar, Adrian D. Hobson, Janel M. Boyce-Rustay, Steve D. Pratt, Anil Vasudevan, Steven Swann, Gricelda H. Simler
Publikováno v:
ChemBioChem. 19:613-621
We describe the design, synthesis, and structure-activity relationships (SARs) of a series of 2-aminobenzothiazole inhibitors of Rho kinases (ROCKs) 1 and 2, which were optimized to low nanomolar potencies by use of protein kinase A (PKA) as a struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e598a04cf2ca6f53d0c4aee341f0a73e
https://doi.org/10.1002/cbic.201700547
https://doi.org/10.1002/cbic.201700547
Autor:
Adrian D. Hobson, Mcpherson Michael J
Publikováno v:
Methods in Molecular Biology ISBN: 9781493999286
The majority of ADCs in preclinical and clinical development are for oncology indications where cytotoxic payloads are targeted to antigen-expressing cancer cells. However, the modulation of pathogenic cellular activity via ADC-mediated delivery of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a6208c313311e681ad4625a3564f87
https://doi.org/10.1007/978-1-4939-9929-3_2
https://doi.org/10.1007/978-1-4939-9929-3_2
Autor:
Anil, Vasudevan, Maria A, Argiriadi, Aleksandra, Baranczak, Michael M, Friedman, Julia, Gavrilyuk, Adrian D, Hobson, Jonathan J, Hulce, Sami, Osman, Noel S, Wilson
Publikováno v:
Progress in medicinal chemistry. 58
Covalent modulation of protein function can have multiple utilities including therapeutics, and probes to interrogate biology. While this field is still viewed with scepticism due to the potential for (idiosyncratic) toxicities, significant strides h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f01848ab660f5c8ddca1f6113bba81d
https://pubmed.ncbi.nlm.nih.gov/30879472
https://pubmed.ncbi.nlm.nih.gov/30879472
Autor:
Julia Gavrilyuk, Wilson Noel S, Jonathan J Hulce, Sami Osman, Maria A. Argiriadi, Anil Vasudevan, Aleksandra Baranczak, Michael Friedman, Adrian D. Hobson
Covalent modulation of protein function can have multiple utilities including therapeutics, and probes to interrogate biology. While this field is still viewed with scepticism due to the potential for (idiosyncratic) toxicities, significant strides h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7503c7128199dd6b6b36ccad1165161
https://doi.org/10.1016/bs.pmch.2018.12.002
https://doi.org/10.1016/bs.pmch.2018.12.002