Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Adrian Coscia"'
Autor:
Pan Yang, Wanyu Li, Xiaoyi Fan, Junhua Pan, Colin J. Mann, Haley Varnum, Lars E. Clark, Sarah A. Clark, Adrian Coscia, Himanish Basu, Katherine Nabel Smith, Vesna Brusic, Jonathan Abraham
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Eastern equine encephalitis virus (EEEV) is the most virulent alphavirus that infects humans, and many survivors develop neurological sequelae, including paralysis and intellectual disability. Alphavirus spike proteins comprise trimers of he
Externí odkaz:
https://doaj.org/article/3558839e2a8445dfb2e6a4a3663d9da4
Autor:
Takaaki Koma, Cheng Huang, Adrian Coscia, Steven Hallam, John T Manning, Junki Maruyama, Aida G Walker, Milagros Miller, Jeanon N Smith, Michael Patterson, Jonathan Abraham, Slobodan Paessler
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009356 (2021)
Several arenaviruses cause hemorrhagic fevers in humans with high case fatality rates. A vaccine named Candid#1 is available only against Junin virus (JUNV) in Argentina. Specific N-linked glycans on the arenavirus surface glycoprotein (GP) mask impo
Externí odkaz:
https://doaj.org/article/61eb758c0e974ffaae50ec79a28710df
Autor:
Katherine G. Nabel, Sarah A. Clark, Sundaresh Shankar, Junhua Pan, Lars E. Clark, Pan Yang, Adrian Coscia, Lindsay G. A. McKay, Haley H. Varnum, Vesna Brusic, Nicole V. Tolan, Guohai Zhou, Michaël Desjardins, Sarah E. Turbett, Sanjat Kanjilal, Amy C. Sherman, Anand Dighe, Regina C. LaRocque, Edward T. Ryan, Casey Tylek, Joel F. Cohen-Solal, Anhdao T. Darcy, Davide Tavella, Anca Clabbers, Yao Fan, Anthony Griffiths, Ivan R. Correia, Jane Seagal, Lindsey R. Baden, Richelle C. Charles, Jonathan Abraham
Publikováno v:
Science
Many studies have examined the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant strains. Here, we evaluate the consequences of further viral evolution. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9850b307f3dab4d7e12ef6670e46c550
https://doi.org/10.1126/science.abl6251
https://doi.org/10.1126/science.abl6251
Autor:
Vicki H. Wysocki, Jonathan Abraham, Donald E. Ingber, David Baker, Inna Goreshnik, Ta-Yi Yu, Lars Clark, Daniel Olal, Nur Mustafaoglu, Danny D. Sahtoe, Adrian Coscia, Florian Busch, Ivan Vulovic, Lance Stewart, Yu-Ru Lin, Lauren Miller
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The de novo design of proteins that bind natural target proteins is useful for a variety of biomedical and biotechnological applications. We describe a design strategy to target proteins containing an exposed beta edge strand. We use the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d5e66e3f3a50332524ae7249dcc96f
https://pubmed.ncbi.nlm.nih.gov/33879614
https://pubmed.ncbi.nlm.nih.gov/33879614
Autor:
Michael Patterson, Jonathan Abraham, Aida G. Walker, Adrian Coscia, Cheng Huang, Milagros Miller, Slobodan Paessler, Jeanon N. Smith, John T. Manning, Takaaki Koma, Junki Maruyama, Steven Hallam
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009356 (2021)
PLoS Pathogens
PLoS Pathogens
Several arenaviruses cause hemorrhagic fevers in humans with high case fatality rates. A vaccine named Candid#1 is available only against Junin virus (JUNV) in Argentina. Specific N-linked glycans on the arenavirus surface glycoprotein (GP) mask impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d4ca4ba8a69474b24fe96b3577a565
https://doaj.org/article/61eb758c0e974ffaae50ec79a28710df
https://doaj.org/article/61eb758c0e974ffaae50ec79a28710df
Autor:
Sarah A. Clark, Lindsay G. A. McKay, Sundaresh Shankar, Jonathan Abraham, Anthony Griffiths, Rebecca I. Johnson, Lars Clark, Junhua Pan, Adrian Coscia
Publikováno v:
bioRxiv : the preprint server for biology.
The SARS-CoV-2 viral spike (S) protein mediates attachment and entry into host cells and is a major target of vaccine and drug design. Potent SARS-CoV-2 neutralizing antibodies derived from closely related antibody heavy chain genes (IGHV3-53 or 3-66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2184c0bd840da27d8e692d44f6cee466
https://pubmed.ncbi.nlm.nih.gov/33831372
https://pubmed.ncbi.nlm.nih.gov/33831372
Autor:
Jeffrey D. Tamucci, Emily A. Ng, Xianlin Han, Nicholas A. Eddy, Kevin J. Boyd, Eric R. May, Nathan N. Alder, Hazel H. Szeto, Meixia Pan, Adrian Coscia, Wayne Mitchell, Murugappan Sathappa
Mitochondrial dysfunction includes heritable diseases, acquired pathologies, and age-related declines in health. Szeto-Schiller (SS) peptides comprise a class of amphipathic tetrapeptides that have demonstrated efficacy in treating a wide array of mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fc5b5260d70595618cec0fe7e43307
https://doi.org/10.1101/735001
https://doi.org/10.1101/735001
Autor:
Lindsay G. A. McKay, Sundaresh Shankar, Manish Chandra Choudhary, Anthony Griffiths, James Regan, Lars Clark, Jonathan Abraham, Rebecca I. Johnson, Vesna Brusic, Junhua Pan, Sarah A. Clark, Adrian Coscia, Jonathan Z. Li
Publikováno v:
Cell
bioRxiv
bioRxiv
Many individuals mount nearly identical antibody responses to SARS-CoV-2. To gain insight into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response to common antibody responses, we studied mutations occurring during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c48ead31ea97f6a6c9f031475e5c97
https://doi.org/10.1016/j.cell.2021.03.027
https://doi.org/10.1016/j.cell.2021.03.027
Autor:
Murugappan Sathappa, Wayne Mitchell, Eric R. May, Kevin J. Boyd, Hazel H. Szeto, Nathan N. Alder, Adrian Coscia
Publikováno v:
Biophysical Journal. 112:438a
Szeto-Schiller (SS) peptides are synthetic tetrapeptides containing an alternating aromatic-cationic motif. They are readily taken up by cells and are targeted to the mitochondrial inner membrane. Among them, SS-31 has been shown to bind to bilayers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb49b1cac0ad88883c6181df4d1f5d0
https://doi.org/10.1016/j.bpj.2016.11.2339
https://doi.org/10.1016/j.bpj.2016.11.2339