Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Adrian B McDermott"'
Autor:
Stephen R Walsh, Cynthia L Gay, Shelly T Karuna, Ollivier Hyrien, Timothy Skalland, Kenneth H Mayer, Magdalena E Sobieszczyk, Lindsey R Baden, Paul A Goepfert, Carlos Del Rio, Guiseppe Pantaleo, Philip Andrew, Carissa Karg, Zonglin He, Huiyin Lu, Carmen A Paez, Jane A G Baumblatt, Laura L Polakowski, Wairimu Chege, Maija A Anderson, Sophie Janto, Xue Han, Yunda Huang, Julie Dumond, Margaret E Ackerman, Adrian B McDermott, Britta Flach, Estelle Piwowar-Manning, Kelly Seaton, Georgia D Tomaras, David C Montefiori, Lucio Gama, John R Mascola, HVTN 127/HPTN 087 Study Team
Publikováno v:
PLoS Medicine, Vol 21, Iss 6, p e1004329 (2024)
BackgroundBroadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the Antibody Mediated Prevention (AMP) trials, a CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% prevention
Externí odkaz:
https://doaj.org/article/4be70ce338214ab0a34f240e9ededde1
Autor:
Dustin M McCraw, Mallory L Myers, Neetu M Gulati, Madhu Prabhakaran, Joshua Brand, Sarah Andrews, John R Gallagher, Samantha Maldonado-Puga, Alexander J Kim, Udana Torian, Hubza Syeda, Seyhan Boyoglu-Barnum, Masaru Kanekiyo, Adrian B McDermott, Audray K Harris
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011514 (2023)
Despite the availability of seasonal vaccines and antiviral medications, influenza virus continues to be a major health concern and pandemic threat due to the continually changing antigenic regions of the major surface glycoprotein, hemagglutinin (HA
Externí odkaz:
https://doaj.org/article/82d3481038c84757a30ef4e14fbf435c
Autor:
Hai Nguyen-Tran, Sang Woo Park, Kevin Messacar, Samuel R Dominguez, Matthew R Vogt, Sallie Permar, Perdita Permaul, Michelle Hernandez, Daniel C Douek, Adrian B McDermott, C Jessica E Metcalf, Bryan Grenfell, Alicen B Spaulding
Publikováno v:
The Lancet Microbe, Vol 3, Iss 2, Pp e83-e85 (2022)
Externí odkaz:
https://doaj.org/article/96fe1ce551d4427092df1e439270ef55
Autor:
Michael J Mina, C Jessica E Metcalf, Adrian B McDermott, Daniel C Douek, Jeremy Farrar, Bryan T Grenfell
Publikováno v:
eLife, Vol 9 (2020)
SARS-CoV-2 presents an unprecedented international challenge, but it will not be the last such threat. Here, we argue that the world needs to be much better prepared to rapidly detect, define and defeat future pandemics. We propose that a Global Immu
Externí odkaz:
https://doaj.org/article/c1ab745f0f1545b0b68b0f9ced7c18ae
Autor:
Hugh C Welles, Madeleine F Jennewein, Rosemarie D Mason, Sandeep Narpala, Lingshu Wang, Cheng Cheng, Yi Zhang, John-Paul Todd, Jeffrey D Lifson, Alejandro B Balazs, Galit Alter, Adrian B McDermott, John R Mascola, Mario Roederer
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007395 (2018)
Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such as HIV. We used a rhesus macaque animal model to optimize delivery of naturally-arising, au
Externí odkaz:
https://doaj.org/article/7eecd2e6b1874777aea557531aa773a2
Autor:
Martin R Gaudinski, Emily E Coates, Katherine V Houser, Grace L Chen, Galina Yamshchikov, Jamie G Saunders, LaSonji A Holman, Ingelise Gordon, Sarah Plummer, Cynthia S Hendel, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Sandra Sitar, Kevin Carlton, Carolyn Laurencot, Robert T Bailer, Sandeep Narpala, Adrian B McDermott, Aryan M Namboodiri, Janardan P Pandey, Richard M Schwartz, Zonghui Hu, Richard A Koup, Edmund Capparelli, Barney S Graham, John R Mascola, Julie E Ledgerwood, VRC 606 Study Team
Publikováno v:
PLoS Medicine, Vol 15, Iss 1, p e1002493 (2018)
BACKGROUND:VRC01 is a human broadly neutralizing monoclonal antibody (bnMAb) against the CD4-binding site of the HIV-1 envelope glycoprotein (Env) that is currently being evaluated in a Phase IIb adult HIV-1 prevention efficacy trial. VRC01LS is a mo
Externí odkaz:
https://doaj.org/article/7064e5c4178543e0a29e54c0e8e750e5
Autor:
Godelieve J de Bree, Adam K Wheatley, Rebecca M Lynch, Madhu Prabhakaran, Marlous L Grijsen, Jan M Prins, Stephen D Schmidt, Richard A Koup, John R Mascola, Adrian B McDermott
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
BACKGROUND:Neutralizing antibodies develop in natural HIV-1 infection. Their development often takes several years and may rely on chronic virus exposure. At the same time recent studies show that treatment early in infection may provide opportunitie
Externí odkaz:
https://doaj.org/article/0814e071ae094b289f28b43c05ac2a0a
Autor:
Michelle C Crank, Eleanor M P Wilson, Laura Novik, Mary E Enama, Cynthia S Hendel, Wenjuan Gu, Martha C Nason, Robert T Bailer, Gary J Nabel, Adrian B McDermott, John R Mascola, Richard A Koup, Julie E Ledgerwood, Barney S Graham, VRC012 Study Team
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166393 (2016)
BACKGROUND:VRC 012 was a Phase I study of a prototype recombinant adenoviral-vector serotype-35 (rAd35) HIV vaccine, the precursor to two recently published clinical trials, HVTN 077 and 083. On the basis of prior evaluation of multiclade rAd5 HIV va
Externí odkaz:
https://doaj.org/article/60ff6ef8e2674931b3b78aadb15768ec
Autor:
Uzma N Sarwar, Laura Novik, Mary E Enama, Sarah A Plummer, Richard A Koup, Martha C Nason, Robert T Bailer, Adrian B McDermott, Mario Roederer, John R Mascola, Julie E Ledgerwood, Barney S Graham, VRC 015 study team
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106240 (2014)
Needle-free delivery improves the immunogenicity of DNA vaccines but is also associated with more local reactogenicity. Here we report the first comparison of Biojector and needle administration of a candidate rAd5 HIV vaccine.Thirty-one adults, 18-5
Externí odkaz:
https://doaj.org/article/47b0305e6d714b118f267d172a9204d1
Autor:
Cindy X. Cai, Nicole A. Doria-Rose, Nicole A. Schneck, Vera B. Ivleva, Brad Tippett, William R. Shadrick, Sarah O’Connell, Jonathan W. Cooper, Zachary Schneiderman, Baoshan Zhang, Daniel B. Gowetski, Daniel Blackstock, Jacob Demirji, Bob C. Lin, Jason Gorman, Tracy Liu, Yile Li, Adrian B. McDermott, Peter D. Kwong, Kevin Carlton, Jason G. Gall, Q. Paula Lei
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract CAP256V2LS, a broadly neutralizing monoclonal antibody (bNAb), is being pursued as a promising drug for HIV-1 prevention. The total level of tyrosine-O-sulfation, a post-translational modification, was known to play a key role for antibody b
Externí odkaz:
https://doaj.org/article/92e48070fe3244d88988a4135f9f4025