Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Adrian Staab"'
Autor:
Ralf Schneider, Alessandra Bolsi, C. Ares, Eugen B. Hug, Barbara Rombi, Beate Timmermann, Francesca Albertini, Antony J. Lomax, Adrian Staab, Gudrun Goitein
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 86:578-584
Purpose To evaluate the clinical results of fractionated spot-scanning proton radiation therapy (PT) in 26 pediatric patients treated at Paul Scherrer Institute for chordoma (CH) or chondrosarcoma (CS) of the skull base or axial skeleton. Methods and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536896631bc50525e603c083c7043f77
https://doi.org/10.1016/j.ijrobp.2013.02.026
https://doi.org/10.1016/j.ijrobp.2013.02.026
Autor:
Adrian Staab, Claudiu T. Supuran, Carsten Hagemann, Michael Flentje, Jelena Anacker, Andrea Scozzafava, Bülent Polat, Fabrizio Carta, Harun M. Said, Giles H. Vince, Astrid Katzer
Publikováno v:
Bioorganic & Medicinal Chemistry; Vol 21
Bioorganic & Medicinal Chemistry
Bioorganic & Medicinal Chemistry
HIF-1α regulated genes are mainly responsible for tumour resistance to radiation- and chemo-therapy. Among these genes, carbonic anhydrase isoform IX (CA9) is highly over expressed in many types of cancer especially in high grade brain cancer like G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b937e070b3cde2d22753d09f8aa925
Autor:
Astrid Katzer, Dirk Vordermark, Christian Plathow, Michael Flentje, H. Einsele, Harun M. Said, Markus Fleischer, Juergen Loeffler, Adrian Staab
Publikováno v:
Strahlentherapie und Onkologie. 187:252-259
Hypoxia inducible factor-1 has been identified as a potential target to overcome hypoxia-induced radioresistance The aim of the present study was to investigate whether selective HIF-1 inhibition via small interfering RNA (siRNA) targeting hypoxia-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc2f0eccbbeebc2a91f9b434543b43b
https://doi.org/10.1007/s00066-011-2167-0
https://doi.org/10.1007/s00066-011-2167-0
Autor:
Michael Flentje, Claudiu T. Supuran, Buelent Polat, Adrian Staab, Jelena Anacker, Andrea Scozzafava, Dirk Vordermark, Carsten Hageman, Harun M. Said, Astrid Katzer
Publikováno v:
Current Pharmaceutical Design. 16:3288-3299
Hypoxia is a crucial factor in tumour aggressiveness and its treatment resistance, particularly in human brain cancer. Tumour resistance against radiation- and chemo- therapy is facilitated by oxygenation reduction at tumour areas. HIF-1α regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4555013bfbb9a0d03f6cdbac62aa1c7
https://doi.org/10.2174/138161210793429788
https://doi.org/10.2174/138161210793429788
Publikováno v:
Current Medicinal Chemistry. 15:322-338
Poor oxygenation of solid tumors is a major indicator of adverse prognosis after standard treatment, e.g. radiotherapy. This observation founded on intratumoral pO(2) electrode measurements has been supported more recently by studies of injected hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e9569934753e07e9598702097f5642
https://doi.org/10.2174/092986708783497391
https://doi.org/10.2174/092986708783497391
Autor:
Dirk Vordermark, Adrian Staab, Bülent Polat, Melanie Beyer, Harun M. Said, Hermann Einsele, Michael Flentje, Astrid Katzer, Jürgen Löffler
Publikováno v:
Strahlentherapie und Onkologie. 183:366-373
The hypoxic accumulation of the transcription factor subunit hypoxia-inducible factor-1alpha (HIF-1alpha), a potential endogenous hypoxia marker and therapeutic target, has recently been shown to strongly depend on glucose availability. The aim of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c311ee65bf24d597d941e08a194c8ce
https://doi.org/10.1007/s00066-007-1649-6
https://doi.org/10.1007/s00066-007-1649-6
Autor:
Dirk Vordermark, Michael Flentje, Harun M. Said, Siglinde Kühnel, Adrian Staab, Jelena Stojic, Carsten Hagemann, Giles H. Vince, Klaus Roosen
Publikováno v:
Radiotherapy and Oncology. 83:398-405
To identify molecular markers of tumor hypoxia and potential therapeutic targets in glioblastoma (GBM), we investigated the hypoxia-related expression of osteopontin (OPN), carbonic anhydrase 9 (CA9), erythropoietin (EPO), vascular endothelial growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abba88da10da6147340e925f5eee38a1
https://doi.org/10.1016/j.radonc.2007.05.003
https://doi.org/10.1016/j.radonc.2007.05.003
Autor:
Carsten Hagemann, M. Guckenberger, Buelent Polat, Susanne Stein, Astrid Katzer, Michael Flentje, Dirk Vordermark, Adrian Staab, Harun M. Said, Jelena Anacker
AIM: To study short dsRNA oligonucleotides (siRNA) as a potent tool for artificially modulating gene expression of N-Myc down regulated gene 1 (NDRG1) gene induced under different physiological conditions (Normoxia and hypoxia) modulating NDRG1 trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9315f93e3855eb1f5cd643c1863dc06d
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12338
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12338
Autor:
Dirk Vordermark, Jelena Anacker, Michael Flentje, M. Guckenberger, Adrian Staab, Carsten Hagemann, Buelent Polat, Harun M. Said
Publikováno v:
BMEI
siRNA is a potent tool for artificially modulating gene expression through the introduction of short interfering RNAs. NDRG1 is a member of the N-myc downregulated gene (NDRG) family and is induced via different physiological and pathological conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e618bd318050433bf3bbd44f040911be
https://doi.org/10.1109/bmei.2011.6098607
https://doi.org/10.1109/bmei.2011.6098607
Autor:
Beate Timmermann, Eugen B. Hug, Gudrun Goitein, Ralf Schneider, Hans Peter Rutz, Adrian Staab, Francesca Albertini, C. Ares, Alessandra Bolsi, Antony J. Lomax
Publikováno v:
International journal of radiation oncology, biology, physics. 81(4)
Purpose To evaluate effectiveness and safety of spot-scanning-based proton-radiotherapy (PT) for extracranial chordomas (ECC). Methods and Material Between 1999–2006, 40 patients with chordoma of C-, T-, and L-spine and sacrum were treated at Paul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63404e374f9a1bf57bae9ab038eb9d9
https://pubmed.ncbi.nlm.nih.gov/21497457
https://pubmed.ncbi.nlm.nih.gov/21497457