Výsledky vyhledávání - "Adrian, Vella"

Akademický článek

Implementation of genomic medicine for rare disease in a tertiary healthcare system: Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD)

Autor: Filippo Pinto e Vairo, Jennifer L. Kemppainen, Carolyn R. Rohrer Vitek, Denise A. Whalen, Kayla J. Kolbert, Kaitlin J. Sikkink, Sarah A. Kroc, Teresa Kruisselbrink, Gabrielle F. Shupe, Alyssa K. Knudson, Elizabeth M. Burke, Elle C. Loftus, Lorelei A. Bandel, Carri A. Prochnow, Lindsay A. Mulvihill, Brittany Thomas, Dale M. Gable, Courtney B. Graddy, Giovanna G. Moreno Garzon, Idara U. Ekpoh, Eva M. Carmona Porquera, Fernando C. Fervenza, Marie C. Hogan, Mireille El Ters, Kenneth J. Warrington, John M. Davis, Matthew J. Koster, Amir B. Orandi, Matthew L. Basiaga, Adrian Vella, Seema Kumar, Ana L. Creo, Aida N. Lteif, Siobhan T. Pittock, Peter J. Tebben, Ejigayehu G. Abate, Avni Y. Joshi, Elizabeth H. Ristagno, Mrinal S. Patnaik, Lisa A. Schimmenti, Radhika Dhamija, Sonia M. Sabrowsky, Klaas J. Wierenga, Mira T. Keddis, Niloy Jewel J. Samadder, Richard J. Presutti, Steven I. Robinson, Michael C. Stephens, Lewis R. Roberts, William A. Faubion, Sherilyn W. Driscoll, Lily C. Wong-Kisiel, Duygu Selcen, Eoin P. Flanagan, Vijay K. Ramanan, Lauren M. Jackson, Michelle L. Mauermann, Victor E. Ortega, Sarah A. Anderson, Stacy L. Aoudia, Eric W. Klee, Tammy M. McAllister, Konstantinos N. Lazaridis

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-10 (2023)

Abstract Background In the United States, rare disease (RD) is defined as a condition that affects fewer than 200,000 individuals. Collectively, RD affects an estimated 30 million Americans. A significant portion of RD has an underlying genetic cause

Externí odkaz: https://doaj.org/article/379d322058a142068b8b67a35317dec9

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Akademický článek

Guidelines, position statements, and advisories for the primary prevention of type 2 diabetes, hypertension, and cardiovascular disease in rural populations: A systematic review protocol.

Autor: Hanieh Sadat Tabatabaei Yeganeh, Larry J Prokop, Shangwe A Kiliaki, Karthik Gnanapandithan, Mohammed Yousufuddin, Adrian Vella, Victor M Montori, Sagar B Dugani

Publikováno v: PLoS ONE, Vol 18, Iss 6, p e0288116 (2023)

IntroductionGlobally, noncommunicable diseases (NCDs), which include type 2 diabetes (T2D), hypertension, and cardiovascular disease (CVD), are associated with a high burden of morbidity and mortality. Health disparities exacerbate the burden of NCDs

Externí odkaz: https://doaj.org/article/53283d873b6f49458a98ecfc57892bfb

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Akademický článek

The relationship between insulin and glucagon concentrations in non‐diabetic humans

Autor: Marcello C. Laurenti, Praveer Arora, Chiara Dalla Man, James C. Andrews, Robert A. Rizza, Aleksey Matveyenko, Kent R. Bailey, Claudio Cobelli, Adrian Vella

Publikováno v: Physiological Reports, Vol 10, Iss 13, Pp n/a-n/a (2022)

Abstract Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show an inverse coordinated relationship. However, dysregulation of α�

Externí odkaz: https://doaj.org/article/47de651730664b97a1c702f3f237b300

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Akademický článek

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy s

Externí odkaz: https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3

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Akademický článek

Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes

Autor: Naureen Javeed, Tracy K. Her, Matthew R. Brown, Patrick Vanderboom, Kuntol Rakshit, Aoife M. Egan, Adrian Vella, Ian Lanza, Aleksey V. Matveyenko

Publikováno v: Cell Reports, Vol 36, Iss 8, Pp 109613- (2021)

Summary: Coordinated communication among pancreatic islet cells is necessary for maintenance of glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been shown to perturb β cell communication and function. Compelling

Externí odkaz: https://doaj.org/article/f6142bb336574cc9a398c46f3da9ef28

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Akademický článek

Coronary microvascular dysfunction is associated with poor glycemic control amongst female diabetics with chest pain and non-obstructive coronary artery disease

Autor: Jaskanwal D. Sara, Riad Taher, Nikhil Kolluri, Adrian Vella, Lilach O. Lerman, Amir Lerman

Publikováno v: Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-12 (2019)

Abstract Background Patients with type 2 diabetes mellitus are at an increased risk of adverse cardiovascular events compared to those without diabetes. The timing, relative to disease onset, and degree of glycemic control that reduces the risk of ad

Externí odkaz: https://doaj.org/article/44af5cb624c242c3974968039b9c0d5a

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Akademický článek

Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes

Autor: Gerardo Calderon, Alison McRae, Juraj Rievaj, Judith Davis, Inuk Zandvakili, Sara Linker-Nord, Duane Burton, Geoffrey Roberts, Frank Reimann, Bronislava Gedulin, Adrian Vella, Nicholas F LaRusso, Michael Camilleri, Fiona M Gribble, Andres Acosta

Publikováno v: EBioMedicine, Vol 55, Iss , Pp - (2020)

Background: The bile acid (BA) pathway plays a role in regulation of food intake and glucose metabolism, based mainly on findings in animal models. Our aim was to determine whether the BA pathway is altered and correctable in human obesity and diabet

Externí odkaz: https://doaj.org/article/81f621a9ddf64e54b9db7c70d00bcc3d

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Akademický článek

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose

Autor: Santhosh Karanth, J.D. Adams, Maria de los Angeles Serrano, Ezekiel B. Quittner-Strom, Judith Simcox, Claudio J. Villanueva, Lale Ozcan, William L. Holland, H. Joseph Yost, Adrian Vella, Amnon Schlegel

Publikováno v: Cell Reports, Vol 24, Iss 2, Pp 312-319 (2018)

Summary: The common genetic variation at rs8004664 in the FOXN3 gene is independently and significantly associated with fasting blood glucose, but not insulin, in non-diabetic humans. Recently, we reported that primary hepatocytes from rs8004664 hype

Externí odkaz: https://doaj.org/article/c4f7548fd33b421ea2c46f5ffbc12106

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Akademický článek

Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function

Autor: Sudha S. Shankar, Douglas S. Lee, Ralph H. Raymond, Roberto A. Calle, Claudio Cobelli, Atalanta Ghosh, R. Paul Robertson, Hartmut Ruetten, Myrlene A. Staten, Darko Stefanovski, Adrian Vella, Sanya Whitaker, David A. Fryburg

Publikováno v: Contemporary Clinical Trials Communications, Vol 10, Iss , Pp 94-99 (2018)

Standard practice to minimize variability in beta cell function (BCF) measurement is to test in inpatient (IP) settings. IP testing strains trial subjects, investigators, and budgets. Outpatient (OP) testing may be a solution although there are few r

Externí odkaz: https://doaj.org/article/93654348a84b46b193cff126cf88a764

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