Zobrazeno 1 - 10
of 341
pro vyhledávání: '"Adrian, Goldman"'
Autor:
Jessica C. Boakes, Steven. P. D. Harborne, Jessie T. S. Ngo, Christos Pliotas, Adrian Goldman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Human equilibrative nucleoside transporters represent a major pharmaceutical target for cardiac, cancer and viral therapies. Understanding the molecular basis for transport is crucial for the development of improved therapeutics through structure-bas
Externí odkaz:
https://doaj.org/article/f96b77b34352440880f14624b689e698
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010578 (2022)
Membrane-integral pyrophosphatases (mPPases) are membrane-bound enzymes responsible for hydrolysing inorganic pyrophosphate and translocating a cation across the membrane. Their function is essential for the infectivity of clinically relevant protozo
Externí odkaz:
https://doaj.org/article/2b179b09f8644df08a9ca16c37a4c260
Autor:
Konstantin Kogan, Karita Haapasalo, Tommi Kotila, Robin Moore, Pekka Lappalainen, Adrian Goldman, Taru Meri
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010338 (2022)
Immune evasion facilitates survival of Borrelia, leading to infections like relapsing fever and Lyme disease. Important mechanism for complement evasion is acquisition of the main host complement inhibitor, factor H (FH). By determining the 2.2 Å cr
Externí odkaz:
https://doaj.org/article/e2881d03e0494f5d88d863c96523e8bc
Autor:
Mimmu K. Hiltunen, Alex J. Timmis, Maren Thomsen, Danai S. Gkotsi, Hideo Iwaï, Orquidea M. Ribeiro, Adrian Goldman, Natalia A. Riobo-Del Galdo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2682 (2023)
Deleterious mutations in the X-linked Patched domain-containing 1 (PTCHD1) gene may account for up to 1% of autism cases. Despite this, the PTCHD1 protein remains poorly understood. Structural similarities to Patched family proteins point to a role i
Externí odkaz:
https://doaj.org/article/7d7d3a2e196843389483252be995e8b6
Autor:
Shang-Te Danny Hsu, Yun-Tzai Cloud Lee, Kornelia M. Mikula, Sofia M. Backlund, Igor Tascón, Adrian Goldman, Hideo Iwaï
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Knots have attracted scientists in mathematics, physics, biology, and engineering. Long flexible thin strings easily knot and tangle as experienced in our daily life. Similarly, long polymer chains inevitably tend to get trapped into knots. Little is
Externí odkaz:
https://doaj.org/article/9c596a763eb44327a9496062bfed193e
Autor:
Cristina Cecchetti, Jannik Strauss, Claudia Stohrer, Claire Naylor, Edward Pryor, Jeanette Hobbs, Simon Tanley, Adrian Goldman, Bernadette Byrne
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254118 (2021)
Membrane proteins have a range of crucial biological functions and are the target of about 60% of all prescribed drugs. For most studies, they need to be extracted out of the lipid-bilayer, e.g. by detergent solubilisation, leading to the loss of nat
Externí odkaz:
https://doaj.org/article/22e197f755e54af484c0e5dea3a85437
Autor:
Alex van Belkum, Carina Almeida, Benjamin Bardiaux, Sarah V. Barrass, Sarah J. Butcher, Tuğçe Çaykara, Sounak Chowdhury, Rucha Datar, Ian Eastwood, Adrian Goldman, Manisha Goyal, Lotta Happonen, Nadia Izadi-Pruneyre, Theis Jacobsen, Pirjo H. Johnson, Volkhard A. J. Kempf, Andreas Kiessling, Juan Leva Bueno, Anchal Malik, Johan Malmström, Ina Meuskens, Paul A. Milner, Michael Nilges, Nicole Pamme, Sally A. Peyman, Ligia R. Rodrigues, Pablo Rodriguez-Mateos, Maria G. Sande, Carla Joana Silva, Aleksandra Cecylia Stasiak, Thilo Stehle, Arno Thibau, Diana J. Vaca, Dirk Linke
Publikováno v:
Diagnostics, Vol 11, Iss 7, p 1259 (2021)
Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where
Externí odkaz:
https://doaj.org/article/489cc0016c134be3b318bf59f4b4c4f1
Autor:
Kun-Mou Li, Craig Wilkinson, Juho Kellosalo, Jia-Yin Tsai, Tommi Kajander, Lars J. C. Jeuken, Yuh-Ju Sun, Adrian Goldman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
In some parasites, membrane-bound pyrophosphatases, which couple proton and sodium ion transport across the membrane, are important for infectivity. Here, the authors report crystal structures of these proteins alongside biophysical analyses that all
Externí odkaz:
https://doaj.org/article/9bf03144000f411fad9765f84873b5f9
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Membrane integral pyrophosphatases (mPPases) are responsible for the hydrolysis of pyrophosphate. This enzymatic mechanism is coupled to the pumping of H+ or Na+ across membranes in a process that can be K+ dependent or independent. Understanding the
Externí odkaz:
https://doaj.org/article/2d41e110bfbf4546b2bb29b9f33da4a2
Publikováno v:
AIMS Biophysics, Vol 3, Iss 1, Pp 171-194 (2016)
Membrane-integral pyrophosphatases (mPPases) are found in several human pathogens, including Plasmodium species, the protozoan parasites that cause malaria. These enzymes hydrolyze pyrophosphate and couple this to the pumping of ions (H+ and/or Na+)
Externí odkaz:
https://doaj.org/article/6f96bafa07cd42bbb233f40f5a021ee2