Zobrazeno 1 - 10
of 870
pro vyhledávání: '"Adrian, Danek"'
Autor:
Christopher M. Weise, Annerose Engel, Maryna Polyakova, Qiong Wu, Karsten Mueller, Sabine Herzig, Robert Jech, Janine Diehl-Schmid, Lina Riedl, Sarah Anderl-Straub, Johannes Kornhuber, Klaus Fassbender, Jens Wiltfang, Klaus Fliessbach, Johannes Prudlo, Matthis Synofzik, Adrian Danek, Markus Otto, Matthias L. Schroeter, for the FTLD Consortium Germany
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Behavioral variant frontotemporal dementia (bvFTD) is characterized by profound and early deficits in social cognition (SC) and executive functions (EF). To date it remains unclear whether deficits of the respective cognitive domains are bas
Externí odkaz:
https://doaj.org/article/80788a3e5215425a97484e9e371cda49
Autor:
Ruth H. Walker, Mariana Barreto, James R. Bateman, M. Leonor Bustamante, Graham Chiu, Scott Feitell, Beat M. Frey, Patricio Guerra, Sofia Guerrero, Hans H. Jung, Fernando Maldonado, Eduardo Meyer, Marcelo Miranda, Emelie McFarland, Patricia Oates, Gorka Ochoa, Karin Olsson, Martin Paucar, Jonatan Alvarez Proschle, Esther M. Sammler, Monica Troncoso, Rachel Wu-Wallace, Leo Young, Sunitha Vege, Connie M. Westhoff, Adrian Danek
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
XK disease is a very rare, multi-system disease, which can present with a wide spectrum of symptoms. This disorder can also be identified pre-symptomatically with the incidental detection of serological abnormalities when typing erythrocytes in perip
Externí odkaz:
https://doaj.org/article/6593764dccbd407cabe77da3d2d6c3c6
Autor:
Franziska Albrecht, Karsten Mueller, Tommaso Ballarini, Klaus Fassbender, Jens Wiltfang, Markus Otto, Robert Jech, Mattias L. Schroeter, Adrian Danek, Janine Diehl-Schmid, Holger Jahn, Jan Kassubek, Johannes Kornhuber, Bernhard Landwehrmeyer, Martin Lauer, Johannes Prudlo, Anja Schneider, Albert C. Ludolph, Klaus Fliesbach, Sarah Anderl-Straub, Katharina Brüggen, Marie Fischer, Hans Förstl, Anke Hammer, György Homola, Walter Just, Johannes Levin, Nicolai Marroquin, Anke Marschhauser, Danielé Pino, Magdalena Nagl, Timo Oberstein, Lea Hüper, Maryna Polyakova, Hannah Pellkofer, Tanja Richter-Schmidinger, Carola Rossmeier, Marianna Kulko, Elisa Semler, Annika Spottke, Petra Steinacker, Angelika Thöne-Otto, Ingo Uttner, Heike Zech
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e34910- (2024)
Progressive supranuclear palsy (PSP) is an atypical Parkinsonian syndrome characterized initially by falls and eye movement impairment. This multimodal imaging study aimed at eliciting structural and functional disease-specific brain alterations. T1-
Externí odkaz:
https://doaj.org/article/512938e68e87433097744a778848f048
Publikováno v:
Contact, Vol 6 (2023)
The two very rare neurodegenerative diseases historically known as the “neuroacanthocytosis syndromes” are due to mutations of either VPS13A or XK. These are phenotypically similar disorders that affect primarily the basal ganglia and hence resul
Externí odkaz:
https://doaj.org/article/46945deddc38488394f8024b85d824e9
Autor:
Emma L. van der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David McFall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G. P. Dopper, Martina Bocchetta, Emily Todd, David Cash, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Chris Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Yolande A. L. Pijnenburg, Markus Otto, Barbara Borroni, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Daniela Galimberti, Sandro Sorbi, Henrik Zetterberg, Eric Huang, John C. van Swieten, Jonathan D. Rohrer, Harro Seelaar, the Genetic Frontotemporal Dementia Initiative (GENFI)
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-13 (2022)
Abstract Background Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity,
Externí odkaz:
https://doaj.org/article/319fc84ce3124ac6ae190548e67faa37
Autor:
Aitana Sogorb-Esteve, Johanna Nilsson, Imogen J. Swift, Carolin Heller, Martina Bocchetta, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, John C. van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Johan Gobom, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Jonathan D. Rohrer, on behalf of the GENetic FTD Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN, and MAPT. Impaired synaptic health is a common mechanism in all three genetic va
Externí odkaz:
https://doaj.org/article/363ff6ee7b3c43748cf18f192e1533a6
Autor:
Leonie Lampe, Sebastian Niehaus, Hans-Jürgen Huppertz, Alberto Merola, Janis Reinelt, Karsten Mueller, Sarah Anderl-Straub, Klaus Fassbender, Klaus Fliessbach, Holger Jahn, Johannes Kornhuber, Martin Lauer, Johannes Prudlo, Anja Schneider, Matthis Synofzik, Adrian Danek, Janine Diehl-Schmid, Markus Otto, FTLD-Consortium Germany, Arno Villringer, Karl Egger, Elke Hattingen, Rüdiger Hilker-Roggendorf, Alfons Schnitzler, Martin Südmeyer, Wolfgang Oertel, German Atypical Parkinson Consortium Study Group, Jan Kassubek, Günter Höglinger, Matthias L. Schroeter
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Importance The entry of artificial intelligence into medicine is pending. Several methods have been used for the predictions of structured neuroimaging data, yet nobody compared them in this context. Objective Multi-class prediction is key f
Externí odkaz:
https://doaj.org/article/432717d710b541bc9487a725d27bb8d9
Autor:
Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma van der Ende, Esther van den Berg, Janne M. Papma, Harro Seelaar, Yolande A. L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Isabel Le Ber, Florence Pasquier, John C. van Swieten, Jonathan D. Rohrer, on behalf of the Genetic FTD Initiative (GENFI)
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia (FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but are lacking in genetic FTD. We aimed to create cognitive compo
Externí odkaz:
https://doaj.org/article/61331b84a57a4e7bb6367b9fcacac52f
Autor:
Kevin Peikert, Adrian Danek
Publikováno v:
Contact, Vol 6 (2023)
In 2020, the pandemic interrupted the series of biannual International Neuroacanthocytosis Meetings that brought together clinicians, scientists, and patient groups to share research into a small group of devastating genetic diseases that combine bot
Externí odkaz:
https://doaj.org/article/630abe4d549d4f59b17570a1ebfacfd7
Autor:
Sonja Schönecker, Carla Palleis, Nicolai Franzmeier, Sabrina Katzdobler, Christian Ferschmann, Sebastian Schuster, Anika Finze, Maximilian Scheifele, Catharina Prix, Urban Fietzek, Endy Weidinger, Georg Nübling, Jonathan Vöglein, Marianne Patt, Henryk Barthel, Osama Sabri, Adrian Danek, Günter U. Höglinger, Matthias Brendel, Johannes Levin
Publikováno v:
NeuroImage: Clinical, Vol 38, Iss , Pp 103402- (2023)
In recent years in vivo visualization of tau deposits has become possible with various PET radiotracers. The tau tracer [18F]PI-2620 proved high affinity both to 3-repeat/4-repeat tau in Alzheimer’s disease as well as to 4-repeat tau in progressive
Externí odkaz:
https://doaj.org/article/68a090d29f7945d0a420e88bf7683b0a