Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia.

Autor: Schneider P; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Crump NT; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK., Arentsen-Peters STCJM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Smith AL; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Hagelaar R; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Adriaanse FRS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Bos RS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., de Jong A; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Nierkens S; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Koopmans B; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Milne TA; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Pieters R; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Stam RW; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. R.W.Stam@prinsesmaximacentrum.nl.

Publikováno v: Experimental hematology & oncology [Exp Hematol Oncol] 2023 Sep 22; Vol. 12 (1), pp. 81. Date of Electronic Publication: 2023 Sep 22.

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1.

Autor: Closa A; The Shine-Dalgarno Centre for RNA Innovation, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; Centre for Computational Biomedical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University, Canberra, Australia., Reixachs-Solé M; The Shine-Dalgarno Centre for RNA Innovation, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; Centre for Computational Biomedical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University, Canberra, Australia., Fuentes-Fayos AC; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.; University of Cordoba (UCO), Cordoba, Spain.; Reina Sofía University Hospital, Cordoba, Spain., Hayer KE; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, USA., Melero JL; The Shine-Dalgarno Centre for RNA Innovation, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; Centre for Computational Biomedical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University, Canberra, Australia., Adriaanse FRS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Bos RS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Torres-Diz M; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, USA., Hunger SP; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, USA., Roberts KG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, USA., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, USA., Stam RW; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Thomas-Tikhonenko A; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA., Castaño JP; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.; University of Cordoba (UCO), Cordoba, Spain.; Reina Sofía University Hospital, Cordoba, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, (CIBERobn), Cordoba, Spain., Luque RM; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.; University of Cordoba (UCO), Cordoba, Spain.; Reina Sofía University Hospital, Cordoba, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, (CIBERobn), Cordoba, Spain., Eyras E; The Shine-Dalgarno Centre for RNA Innovation, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; Centre for Computational Biomedical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University, Canberra, Australia.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.

Publikováno v: NAR cancer [NAR Cancer] 2022 Dec 09; Vol. 4 (4), pp. zcac041. Date of Electronic Publication: 2022 Dec 09 (Print Publication: 2022).