Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia.

Autor: Schneider P; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Crump NT; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK., Arentsen-Peters STCJM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Smith AL; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Hagelaar R; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Adriaanse FRS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Bos RS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., de Jong A; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Nierkens S; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Koopmans B; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Milne TA; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Pieters R; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Stam RW; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. R.W.Stam@prinsesmaximacentrum.nl.

Publikováno v: Experimental hematology & oncology [Exp Hematol Oncol] 2023 Sep 22; Vol. 12 (1), pp. 81. Date of Electronic Publication: 2023 Sep 22.

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1.

Autor: Closa A; The Shine-Dalgarno Centre for RNA Innovation, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; Centre for Computational Biomedical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University, Canberra, Australia., Reixachs-Solé M; The Shine-Dalgarno Centre for RNA Innovation, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; Centre for Computational Biomedical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University, Canberra, Australia., Fuentes-Fayos AC; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.; University of Cordoba (UCO), Cordoba, Spain.; Reina Sofía University Hospital, Cordoba, Spain., Hayer KE; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, USA., Melero JL; The Shine-Dalgarno Centre for RNA Innovation, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; Centre for Computational Biomedical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University, Canberra, Australia., Adriaanse FRS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Bos RS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Torres-Diz M; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, USA., Hunger SP; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, USA., Roberts KG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, USA., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, USA., Stam RW; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Thomas-Tikhonenko A; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA., Castaño JP; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.; University of Cordoba (UCO), Cordoba, Spain.; Reina Sofía University Hospital, Cordoba, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, (CIBERobn), Cordoba, Spain., Luque RM; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.; University of Cordoba (UCO), Cordoba, Spain.; Reina Sofía University Hospital, Cordoba, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, (CIBERobn), Cordoba, Spain., Eyras E; The Shine-Dalgarno Centre for RNA Innovation, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; Centre for Computational Biomedical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University, Canberra, Australia.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.

Publikováno v: NAR cancer [NAR Cancer] 2022 Dec 09; Vol. 4 (4), pp. zcac041. Date of Electronic Publication: 2022 Dec 09 (Print Publication: 2022).

Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins.

Autor: Chen, Tian-Qi¹ (AUTHOR), Huang, Heng-Jing¹ (AUTHOR), Zhu, Shun-Xin¹ (AUTHOR), Chen, Xiao-Tong¹ (AUTHOR), Pu, Ke-Jia¹ (AUTHOR), Wang, Dan² (AUTHOR), An, Yan¹ (AUTHOR), Lian, Jun-Yi¹ (AUTHOR), Sun, Yu-Meng¹ (AUTHOR), Chen, Yue-Qin^1,3 (AUTHOR) lsscyq@mail.sysu.edu.cn, Wang, Wen-Tao^1,3 (AUTHOR) wangwt8@mail.sysu.edu.cn

Publikováno v: Experimental Hematology & Oncology. 2/19/2024, Vol. 13, p1-13. 13p.

Genetic background of thrombocytosis in mice mimicking hereditary thrombocytosis in humans.

Autor: Kimura, Hiroyuki¹ (AUTHOR), Onozawa, Masahiro¹ (AUTHOR) onozawa@med.hokudai.ac.jp, Teshima, Takanori¹ (AUTHOR)

Publikováno v: Platelets. 2023, Vol. 34 Issue 1, p1-4. 4p.

Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines.

Autor: Safa-Tahar-Henni S; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Páez Martinez K; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Gress V; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., Esparza N; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada., Roques É; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Bonnet-Magnaval F; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Bilodeau M; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., Gagné V; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Bresson E; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada., Cardin S; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., El-Hachem N; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., Iasenza I; Centre for Translational Biology, McGill University Heath Centre Research Institute, Montréal, QC, Canada., Alzial G; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Metabolic and Epigenetic Alterations in Cancer Research unit, Montréal, QC, Canada., Boivin I; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Molecular Genetics of Stem Cells Research Unit, Montréal, QC, Canada., Nakamichi N; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada., Soufflet AC; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., Mirela Pascariu C; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Proteomics and Bioanalytical Mass Spectrometry Research Unit, Montréal, QC, Canada., Duchaine J; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; High throughput screening platform, Montréal, QC, Canada., Mathien S; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; High throughput screening platform, Montréal, QC, Canada., Bonneil É; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Proteomics and Bioanalytical Mass Spectrometry Research Unit, Montréal, QC, Canada., Eppert K; Centre for Translational Biology, McGill University Heath Centre Research Institute, Montréal, QC, Canada.; Department of Pediatrics, McGill University, Montréal, QC, Canada., Marinier A; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Medicinal Chemistry/Drug Discovery Unit, Montréal, QC, Canada.; Department of Chemistry, Université de Montréal, Montréal, QC, Canada., Sauvageau G; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Molecular Genetics of Stem Cells Research Unit, Montréal, QC, Canada.; Institut universitaire d'hémato-oncologie et de thérapie cellulaire, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada.; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital Research Center, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Deblois G; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Faculty of Medicine, Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada., Thibault P; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Proteomics and Bioanalytical Mass Spectrometry Research Unit, Montréal, QC, Canada.; Department of Chemistry, Faculty of Arts and Sciences, Université de Montréal, Montréal, QC, Canada., Hébert J; Institut universitaire d'hémato-oncologie et de thérapie cellulaire, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada.; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital Research Center, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Eaves CJ; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Cellot S; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada. sonia.cellot@umontreal.ca.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. sonia.cellot@umontreal.ca., Barabé F; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada. Frederic.Barabe@crchudequebec.ulaval.ca.; Department of Medicine, Université Laval, Quebec City, QC, Canada. Frederic.Barabe@crchudequebec.ulaval.ca., Wilhelm BT; Laboratory for High Throughput Biology, Montréal, QC, Canada. brian.wilhelm@umontreal.ca.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada. brian.wilhelm@umontreal.ca.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. brian.wilhelm@umontreal.ca.

Publikováno v: Leukemia [Leukemia] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.