Zobrazeno 1 - 10
of 435
pro vyhledávání: '"Adriaan P IJzerman"'
Autor:
Willem Jespers, Laura H Heitman, Adriaan P IJzerman, Eddy Sotelo, Gerard J P van Westen, Johan Åqvist, Hugo Gutiérrez-de-Terán
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009152 (2021)
Transmembranal G Protein-Coupled Receptors (GPCRs) transduce extracellular chemical signals to the cell, via conformational change from a resting (inactive) to an active (canonically bound to a G-protein) conformation. Receptor activation is normally
Externí odkaz:
https://doaj.org/article/ed5e77758ad342f7b032db580b22f1c5
Autor:
Marga J Bouma, Christian Freund, Adriaan P IJzerman, Dorret I Boomsma, Christine L Mummery, Karine Raymond
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Lymphoblast cells from four individuals of a family of two genetically unrelated parents and their monozygotic twins were used to generate integration-free human induced pluripotent stem cells (hiPSCs). Reprogramming factors were delivered by co-elec
Externí odkaz:
https://doaj.org/article/6f0d0c1dd6694eb997fd28c6d045c575
Autor:
Luca Sala, Zhiyi Yu, Dorien Ward‐van Oostwaard, Jacobus PD van Veldhoven, Alessandra Moretti, Karl‐Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, Milena Bellin
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1065-1081 (2016)
Abstract Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms o
Externí odkaz:
https://doaj.org/article/767b30a7cd6e491aa4968dd31eb2d71b
Autor:
Gerard J P van Westen, Alwin Hendriks, Jörg K Wegner, Adriaan P Ijzerman, Herman W T van Vlijmen, Andreas Bender
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 2, p e1002899 (2013)
Infection with HIV cannot currently be cured; however it can be controlled by combination treatment with multiple anti-retroviral drugs. Given different viral genotypes for virtually each individual patient, the question now arises which drug combina
Externí odkaz:
https://doaj.org/article/f197fee6c52b4459a61d79705f7ca90c
Autor:
Gerard J P van Westen, Jörg K Wegner, Peggy Geluykens, Leen Kwanten, Inge Vereycken, Anik Peeters, Adriaan P Ijzerman, Herman W T van Vlijmen, Andreas Bender
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27518 (2011)
In quite a few diseases, drug resistance due to target variability poses a serious problem in pharmacotherapy. This is certainly true for HIV, and hence, it is often unknown which drug is best to use or to develop against an individual HIV strain. In
Externí odkaz:
https://doaj.org/article/a056380cc36b4a66bd687e6a2468d1ed
Autor:
Marina Gorostiola González, Remco L. van den Broek, Thomas G.M. Braun, Magdalini Chatzopoulou, Willem Jespers, Adriaan P. IJzerman, Laura H. Heitman, Gerard J.P. van Westen
Proteochemometric (PCM) modelling is a powerful computational drug discovery tool used in bioactivity prediction of potential drug candidates relying on both chemical and protein information. In PCM features are computed to describe small molecules a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48815af3fb6cb4d8a67d679ca410b30c
https://doi.org/10.26434/chemrxiv-2023-90082
https://doi.org/10.26434/chemrxiv-2023-90082
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
GnRH1 and GnRH2 receptors (provisonal nomenclature [39], also called Type I and Type II GnRH receptor, respectively [85]) have been cloned from numerous species, most of which express two or three types of GnRH receptor [85, 84, 114]. GnRH I (p-Glu-H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05ba538b68e303aa3586d7ace044dd4
https://doi.org/10.2218/gtopdb/f31/2023.1
https://doi.org/10.2218/gtopdb/f31/2023.1
Autor:
Alan Wise, M. Gerard Waters, Graeme Semple, Stefan Offermanns, Timothy W. Lovenberg, Adriaan P. IJzerman, Steven L. Colletti
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The hydroxycarboxylic acid family of receptors (ENSFM00500000271913, nomenclature as agreed by the NC-IUPHAR Subcommittee on Hydroxycarboxylic acid receptors [36, 12]) respond to organic acids, including the endogenous hydroxy carboxylic acids 3-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8424a24561efca02ad12bf8e01ad7af
https://doi.org/10.2218/gtopdb/f48/2023.1
https://doi.org/10.2218/gtopdb/f48/2023.1
Autor:
Gary L. Stiles, Ulrich Schwabe, Christa E. Müller, Joel Linden, Karl-Norbert Klotz, Kenneth A. Jacobson, Adriaan P. IJzerman, Rebecca Hills, Bruno G. Frenguelli, Bertil B. Fredholm
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [112]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for the antagonist-bound [155, 316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc4b5988ea942e62d534968888f2e3d
https://doi.org/10.2218/gtopdb/f3/2023.1
https://doi.org/10.2218/gtopdb/f3/2023.1
Autor:
Bert L H, Beerkens, Çağla, Koç, Rongfang, Liu, Bogdan I, Florea, Sylvia E, Le Dévédec, Laura H, Heitman, Adriaan P, IJzerman, Daan, van der Es
Publikováno v:
ACS chemical biology. 17(11)
G protein-coupled receptors (GPCRs) have been known for decades as attractive drug targets. This has led to the development and approval of many ligands targeting GPCRs. Although ligand binding effects have been studied thoroughly for many GPCRs, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6758d955734c581dc85df001534a5323
https://pubmed.ncbi.nlm.nih.gov/36279267
https://pubmed.ncbi.nlm.nih.gov/36279267