Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Adriaan G, Holleboom"'
Autor:
Lars Verschuren, Anne Linde Mak, Arianne van Koppen, Serdar Özsezen, Sonia Difrancesco, Martien P. M. Caspers, Jessica Snabel, David van der Meer, Anne-Marieke van Dijk, Elias Badal Rashu, Puria Nabilou, Mikkel Parsberg Werge, Koen van Son, Robert Kleemann, Amanda J. Kiliaan, Eric J. Hazebroek, André Boonstra, Willem P. Brouwer, Michail Doukas, Saurabh Gupta, Cornelis Kluft, Max Nieuwdorp, Joanne Verheij, Lise Lotte Gluud, Adriaan G. Holleboom, Maarten E. Tushuizen, Roeland Hanemaaijer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Accurate non-invasive biomarkers to diagnose metabolic dysfunction-associated steatotic liver disease (MASLD)-related fibrosis are urgently needed. This study applies a translational approach to develop a blood-based biomarker panel for fibr
Externí odkaz:
https://doaj.org/article/6be533e026b74a099d1ef00fbf2fcead
Autor:
Matthew McTeer, Douglas Applegate, Peter Mesenbrink, Vlad Ratziu, Jörn M Schattenberg, Elisabetta Bugianesi, Andreas Geier, Manuel Romero Gomez, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Hannele Yki-Jarvinen, Michael Allison, Luca Valenti, Luca Miele, Michael Pavlides, Jeremy Cobbold, Georgios Papatheodoridis, Adriaan G Holleboom, Dina Tiniakos, Clifford Brass, Quentin M Anstee, Paolo Missier, LITMUS Consortium investigators
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0299487 (2024)
AimsMetabolic dysfunction Associated Steatotic Liver Disease (MASLD) outcomes such as MASH (metabolic dysfunction associated steatohepatitis), fibrosis and cirrhosis are ordinarily determined by resource-intensive and invasive biopsies. We aim to sho
Externí odkaz:
https://doaj.org/article/67ecf06493dd4d75bdee07628520f62d
Autor:
Daniela Stols-Gonçalves, Anne Linde Mak, Mette S. Madsen, Eduard W. J. van der Vossen, Eveline Bruinstroop, Peter Henneman, Femke Mol, Torsten P. M. Scheithauer, Loek Smits, Julia Witjes, Abraham Stijn Meijnikman, Joanne Verheij, Max Nieuwdorp, Adriaan G. Holleboom, Evgeni Levin
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTIndividuals with nonalcoholic fatty liver disease (NAFLD) have an altered gut microbiota composition. Moreover, hepatic DNA methylation may be altered in the state of NAFLD. Using a fecal microbiota transplantation (FMT) intervention, we aime
Externí odkaz:
https://doaj.org/article/614e1712deb34c56a7a373a90e4405b5
Autor:
Lars E. Larsen, Marjolein A.W. van den Boogert, Wilson A. Rios-Ocampo, Jos C. Jansen, Donna Conlon, Patrick L.E. Chong, J. Han M. Levels, Roos E. Eilers, Vinay V. Sachdev, Noam Zelcer, Tobias Raabe, Miao He, Nicholas J. Hand, Joost P.H. Drenth, David J. Rader, Eric S.G. Stroes, Dirk J. Lefeber, Johan W. Jonker, Adriaan G. Holleboom
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 583-597 (2022)
Background & Aims: Recently, novel inborn errors of metabolism were identified because of mutations in V-ATPase assembly factors TMEM199 and CCDC115. Patients are characterized by generalized protein glycosylation defects, hypercholesterolemia, and f
Externí odkaz:
https://doaj.org/article/f83a6ee89be64fb6964bdd0493f8352e
Autor:
Veera Houttu, Julia Bouts, Yasaman Vali, Joost Daams, Aldo Grefhorst, Max Nieuwdorp, Adriaan G. Holleboom
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundExercise is an effective strategy for the prevention and regression of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD), but it is unclear whether it can reduce advanced stages of NAFLD, i.e., steatohepatitis and
Externí odkaz:
https://doaj.org/article/73680892769540abbd16d46e9eff9039
Autor:
Marian A. Troelstra, Anne-Marieke Van Dijk, Julia J. Witjes, Anne Linde Mak, Diona Zwirs, Jurgen H. Runge, Joanne Verheij, Ulrich H. Beuers, Max Nieuwdorp, Adriaan G. Holleboom, Aart J. Nederveen, Oliver J. Gurney-Champion
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Recent literature suggests that tri-exponential models may provide additional information and fit liver intravoxel incoherent motion (IVIM) data more accurately than conventional bi-exponential models. However, voxel-wise fitting of IVIM results in n
Externí odkaz:
https://doaj.org/article/7d3f47e3e2a64397869ab0de5bffe129
Autor:
Julia J. Witjes, Loek P. Smits, Ceyda T. Pekmez, Andrei Prodan, Abraham S. Meijnikman, Marian A. Troelstra, Kristien E.C. Bouter, Hilde Herrema, Evgeni Levin, Adriaan G. Holleboom, Maaike Winkelmeijer, Ulrich H. Beuers, Krijn vanLienden, Judith Aron‐Wisnewky, Ville Mannisto, Jacques J. Bergman, Jurgen H. Runge, Aart J. Nederveen, Lars O. Dragsted, Prokopis Konstanti, Erwin G. Zoetendal, Willem deVos, Joanne Verheij, Albert K. Groen, Max Nieuwdorp
Publikováno v:
Hepatology Communications, Vol 4, Iss 11, Pp 1578-1590 (2020)
The intestinal microbiota has been linked to the development and prevalence of steatohepatitis in humans. Interestingly, steatohepatitis is significantly lower in individuals taking a plant‐based, low‐animal‐protein diet, which is thought to be
Externí odkaz:
https://doaj.org/article/3a828877c8044547b262b85e4264f55c
Autor:
Daisuke Yamamuro, Hisataka Yamazaki, Jun-ichi Osuga, Kenta Okada, Tetsuji Wakabayashi, Akihito Takei, Shoko Takei, Manabu Takahashi, Shuichi Nagashima, Adriaan G. Holleboom, Masayuki Kuroda, Hideaki Bujo, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 9, Pp 1287-1299 (2020)
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in
Externí odkaz:
https://doaj.org/article/7b302d366e724dc48d0fc049e847b5aa
Autor:
Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly, James Clark, Heather J. Cordell, Rebecca Darlay, Christopher P. Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M. Bossuyt, Adriaan G. Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss
Publikováno v:
JHEP Reports, Vol 4, Iss 2, Pp 100409- (2022)
Background & Aims: Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods: We profiled 2,083 s
Externí odkaz:
https://doaj.org/article/bf7c90fd285b4e33a8d02523458d147c
Autor:
Esmée J Grobbee, Vivian D de Jong, Ilse C Schrieks, Maarten E Tushuizen, Adriaan G Holleboom, Jean-Claude Tardif, A Michael Lincoff, Gregory G Schwartz, Manuel Castro Cabezas, Diederick E Grobbee
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277706 (2022)
BackgroundPeroxisome proliferator-activated receptor (PPAR) agonists may have favorable outcomes on non-alcoholic fatty liver disease. This study serves as proof of concept to evaluate whether dual PPAR-α/γ agonists improve non-invasive tests of li
Externí odkaz:
https://doaj.org/article/5b5d95f9a31641c0967f7bed447b386a