Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Adriaan E. Basson"'
Autor:
Kiran S. Toti, Nicole Pribut, Michael D’Erasmo, Madhuri Dasari, Savita K. Sharma, Perry W. Bartsch, Samantha L. Burton, Hannah B. Gold, Anatoliy Bushnev, Cynthia A. Derdeyn, Adriaan E. Basson, Dennis C. Liotta, Eric J. Miller
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Nucleoside- and nucleotide-based therapeutics are indispensable treatment options for patients suffering from malignant and viral diseases. These agents are most commonly administered to patients as prodrugs to maximize bioavailability and efficacy.
Externí odkaz:
https://doaj.org/article/95897a2077a94f00b1666c0194367d18
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234937 (2020)
We have previously reported on HIV-1 infected patients who fail anti-retroviral therapy but manage to re-suppress without a regimen change despite harbouring major drug resistance mutations. Here we explore phenotypic drug resistance in such patients
Externí odkaz:
https://doaj.org/article/806754f1efbe4f92a833a010a0d57ec5
Autor:
Anatoliy S. Bushnev, Perry W. Bartsch, Savita Sharma, Kyle E. Giesler, Dennis C. Liotta, Eric J. Miller, Madhuri Dasari, D'erasmo Michael, Adriaan E. Basson, Soyon S. Hwang, Akshay Raghuram, Nicole Pribut, Iskandar Sabrina, Samantha L. Burton, Cynthia A. Derdeyn
Publikováno v:
Journal of Medicinal Chemistry. 64:12917-12937
Tenofovir (TFV) is the cornerstone nucleotide reverse transcriptase inhibitor (NtRTI) in many combination antiretroviral therapies prescribed to patients living with HIV/AIDS. Due to poor cell permeability and oral bioavailability, TFV is administere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fe8f64ae776888f4188d89e13f619a
https://doi.org/10.1021/acs.jmedchem.1c01083
https://doi.org/10.1021/acs.jmedchem.1c01083
Publikováno v:
Arkivoc. 2020:152-170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95d2393a79fc1d7265001dc55b111289
https://doi.org/10.24820/ark.5550190.p011.282
https://doi.org/10.24820/ark.5550190.p011.282
Autor:
Heini W. Dirr, Alison Williams, Ikechukwu Achilonu, Yasien Sayed, Lynn Morris, Adriaan E. Basson
Publikováno v:
Biochemical Journal. 476:375-384
HIV protease is essential for processing the Gag polyprotein to produce infectious virions and is a major target in antiretroviral therapy. We have identified an unusual HIV-1 subtype C variant that contains insertions of leucine and asparagine (L38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f64932525013a457753ad38ee075036
https://doi.org/10.1042/bcj20180692
https://doi.org/10.1042/bcj20180692
Autor:
Charles R. K. Changunda, Sandy van Vuuren, Moira L. Bode, Adriaan E. Basson, Amanda L. Rousseau
Publikováno v:
Tetrahedron. 73:137-147
Novel N-, O- and S-substituted pyridyl-benzamides, -benzylamines and -sulfonamides were prepared by means of palladium-catalysed cross-coupling reactions. The synthetic approach, using Pd2(dba)3 as palladium source and rac-BINAP as supporting ligand,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::727d4993f7790e89ca555aa4ce5af8f8
https://doi.org/10.1016/j.tet.2016.11.071
https://doi.org/10.1016/j.tet.2016.11.071
Publikováno v:
Water Research. 104:349-360
The wastewater treatment process, besides discharging pharmaceuticals into the environment, has been found to result in the formation of a variety of undescribed compounds. Here we investigate the laboratory scale chlorination of the commonly used an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0766e56aa81e4efa95f864dec9dde002
https://doi.org/10.1016/j.watres.2016.08.038
https://doi.org/10.1016/j.watres.2016.08.038
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234937 (2020)
PLoS ONE
PLoS ONE
We have previously reported on HIV-1 infected patients who fail anti-retroviral therapy but manage to re-suppress without a regimen change despite harbouring major drug resistance mutations. Here we explore phenotypic drug resistance in such patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405f4c0efc1b8fb5ed6d8184e14692a9
https://doi.org/10.1371/journal.pone.0234937
https://doi.org/10.1371/journal.pone.0234937
Autor:
Nicole Pribut, Stephen C. Pelly, Adriaan E. Basson, Dennis C. Liotta, Willem A. L. van Otterlo
Publikováno v:
ACS medicinal chemistry letters. 10(2)
[Image: see text] Since the discovery of HIV as the etiological agent of AIDS, the virus has infected millions of people each year. Fortunately, with the use of HAART, viremia can be suppressed to below detectable levels in the infected individuals,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92496fe9d10d0706e230611c9b58feb0
https://pubmed.ncbi.nlm.nih.gov/30783503
https://pubmed.ncbi.nlm.nih.gov/30783503
Autor:
Lynn Morris, Louise Kuhn, Elaine J. Abrams, Ashraf Coovadia, Adriaan E. Basson, Renate Strehlau, Gillian Hunt, Jennifer Giandhari
Publikováno v:
AIDS Research and Human Retroviruses. 31:776-782
Studies have shown a low frequency of HIV-1 protease drug resistance mutations in patients failing protease inhibitor (PI)-based therapy. Recent studies have identified mutations in Gag as an alternate pathway for PI drug resistance in subtype B viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4aa5aa30fee03cb2f8a01b7b2c11cc4
https://doi.org/10.1089/aid.2014.0349
https://doi.org/10.1089/aid.2014.0349