Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Adriaan B Houtsmuller"'
Autor:
Lieke Koornneef, Johan A Slotman, Esther Sleddens-Linkels, Wiggert A van Cappellen, Marco Barchi, Attila Tóth, Joost Gribnau, Adriaan B Houtsmuller, Willy M Baarends
Publikováno v:
PLoS Genetics, Vol 18, Iss 7, p e1010046 (2022)
Recombinases RAD51 and its meiosis-specific paralog DMC1 accumulate on single-stranded DNA (ssDNA) of programmed DNA double strand breaks (DSBs) in meiosis. Here we used three-color dSTORM microscopy, and a mouse model with severe defects in meiotic
Externí odkaz:
https://doaj.org/article/73600dd4da354f6792a689909bee6f67
Autor:
Jeffrey Stedehouder, Demi Brizee, Johan A Slotman, Maria Pascual-Garcia, Megan L Leyrer, Bibi LJ Bouwen, Clemens MF Dirven, Zhenyu Gao, David M Berson, Adriaan B Houtsmuller, Steven A Kushner
Publikováno v:
eLife, Vol 8 (2019)
GABAergic fast-spiking parvalbumin-positive (PV) interneurons are frequently myelinated in the cerebral cortex. However, the factors governing the topography of cortical interneuron myelination remain incompletely understood. Here, we report that seg
Externí odkaz:
https://doaj.org/article/4cad7d845a4943d6bf4fae401a2ebf6e
Autor:
Tamara Hoppenbrouwers, Anouchska S A Autar, Andi R Sultan, Tsion E Abraham, Wiggert A van Cappellen, Adriaan B Houtsmuller, Willem J B van Wamel, Heleen M M van Beusekom, Johan W van Neck, Moniek P M de Maat
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176472 (2017)
Multiple inducers of in vitro Neutrophil Extracellular Trap (NET) formation (NETosis) have been described. Since there is much variation in study design and results, our aim was to create a systematic review of NETosis inducers and perform a standard
Externí odkaz:
https://doaj.org/article/2b7d03f564614e1cb8f3d165dff712ab
Quantitation of glucocorticoid receptor DNA-binding dynamics by single-molecule microscopy and FRAP.
Autor:
Femke L Groeneweg, Martin E van Royen, Susanne Fenz, Veer I P Keizer, Bart Geverts, Jurrien Prins, E Ron de Kloet, Adriaan B Houtsmuller, Thomas S Schmidt, Marcel J M Schaaf
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90532 (2014)
Recent advances in live cell imaging have provided a wealth of data on the dynamics of transcription factors. However, a consistent quantitative description of these dynamics, explaining how transcription factors find their target sequences in the va
Externí odkaz:
https://doaj.org/article/d47c3fc061a64d269c690076030ab728
Autor:
W Martijn ter Haar, Magda A Meester-Smoor, Karel H M van Wely, Claudia C M M Schot, Marjolein J F W Janssen, Bart Geverts, Jacqueline Bonten, Gerard C Grosveld, Adriaan B Houtsmuller, Ellen C Zwarthoff
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46085 (2012)
The leukemia-associated fusion protein MN1-TEL combines the transcription-activating domains of MN1 with the DNA-binding domain of the transcriptional repressor TEL. Quantitative photobleaching experiments revealed that ∼20% of GFP-tagged MN1 and T
Externí odkaz:
https://doaj.org/article/d0f348eb9bb8484dbff8f98ebdb66193
Autor:
Sangeetha Hari, Johan A. Slotman, Yoram Vos, Christian Floris, Wiggert A. van Cappellen, C. W. Hagen, Sjoerd Stallinga, Adriaan B. Houtsmuller, Jacob P. Hoogenboom
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Super-resolution fluorescence microscopy can be achieved by image reconstruction after spatially patterned illumination or sequential photo-switching and read-out. Reconstruction algorithms and microscope performance are typically tested usi
Externí odkaz:
https://doaj.org/article/3f31cd4d184c44cc863fdb915eacefde
Autor:
Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, René Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.
Externí odkaz:
https://doaj.org/article/8ae0ddc4ec8841d3a8a8b7435095a252
Autor:
Karin Legerstee, Jason Sueters, Tsion E. Abraham, Johan A. Slotman, Gert-Jan Kremers, Jacob P. Hoogenboom, Adriaan B. Houtsmuller
Publikováno v:
Biology Open, Vol 11, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/0442c45b12564bca8f692c82b784d27d
Autor:
Karin Legerstee, Tsion E. Abraham, Wiggert A. van Cappellen, Alex L. Nigg, Johan A. Slotman, Adriaan B. Houtsmuller
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Focal adhesions (FAs) are flat elongated structures that mediate cell migration and link the cytoskeleton to the extracellular matrix. Along the vertical axis FAs were shown to be composed of three layers. We used structured illumination mic
Externí odkaz:
https://doaj.org/article/04042c18fbe1426ea391cb28c528894f
Autor:
Koen van den Dries, Leila Nahidiazar, Johan A. Slotman, Marjolein B. M. Meddens, Elvis Pandzic, Ben Joosten, Marleen Ansems, Joost Schouwstra, Anke Meijer, Raymond Steen, Mietske Wijers, Jack Fransen, Adriaan B. Houtsmuller, Paul W. Wiseman, Kees Jalink, Alessandra Cambi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Podosomes are actin-based protrusions used by cells for invasion and local degradation but the structure underlying their protrusiveness and mechanosensitivity is unclear. Here, the authors report that podosomes have a modular actin nano-architecture
Externí odkaz:
https://doaj.org/article/f02ec8baa69243f385139e1d26c11672