Výsledky vyhledávání - "Adriaan A van Beek"

Akademický článek

FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background OX40 (CD134) is a costimulatory molecule of the tumor necrosis factor receptor superfamily that is currently being investigated as a target for cancer immunotherapy. However, despite promising results in murine tumor models, the clinical e

Externí odkaz: https://doaj.org/article/e56e3eb9973e485888dbd8bd5af2b0dc

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Akademický článek

Supplementation with Lactobacillus plantarum WCFS1 prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1-/Δ7 Mice

Autor: Adriaan A Van Beek, Bruno Sovran, Floor Hugenholtz, Ben Meijer, Joanne Hoogerland, Violeta Mihailova, Corine van der Ploeg, Clara Belzer, Mark V Boekschoten, Jan JH Hoeijmakers, Wilbert P Vermeij, Paul De Vos, Jerry M Wells, Pieter JM Leenen, Claudio Nicoletti, Rudi W Hendriks, Huub FJ Savelkoul

Publikováno v: Frontiers in Immunology, Vol 7 (2016)

Although it is clear that probiotics improve intestinal barrier function, little is known about the effects of probiotics on the aging intestine. We investigated effects of 10-wk bacterial supplementation of Lactobacillus plantarum WCFS1, Lactobacill

Externí odkaz: https://doaj.org/article/089a5bce46ee410bb166763dc679f0a9

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Akademický článek

Case report: Persistent hypogammaglobulinemia and mixed chimerism after HLA class-II disparate-hematopoietic stem cell transplant

Autor: Melanie de Gier, Ingrid Pico-Knijnenburg, Monique M. van Ostaijen-ten Dam, Dagmar Berghuis, Frans J. Smiers, Adriaan A. van Beek, Hetty Jolink, Patty M. Jansen, Arjan C. Lankester, Mirjam van der Burg

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for various hematological, immunological and metabolic diseases, replacing the patient’s hematopoietic system with donor-derived healthy hematopoietic stem cells. HSC

Externí odkaz: https://doaj.org/article/43cc956a59494f48bfa1c4c189550255

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Akademický článek

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 −/Δ7 mice

Autor: Benthe van der Lugt, Adriaan A. van Beek, Steven Aalvink, Ben Meijer, Bruno Sovran, Wilbert P. Vermeij, Renata M. C. Brandt, Willem M. de Vos, Huub F. J. Savelkoul, Wilma T. Steegenga, Clara Belzer

Publikováno v: Immunity & Ageing, Vol 16, Iss 1, Pp 1-17 (2019)

Abstract Background The use of Akkermansia muciniphila as potential therapeutic intervention is receiving increasing attention. Health benefits attributed to this bacterium include an improvement of metabolic disorders and exerting anti-inflammatory

Externí odkaz: https://doaj.org/article/2009f81821734aafbf450b1122f78a11

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Akademický článek

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

Autor: Adriaan A. van Beek, Floris Fransen, Ben Meijer, Paul de Vos, Edward F. Knol, Huub F. J. Savelkoul

Publikováno v: Immunity & Ageing, Vol 15, Iss 1, Pp 1-11 (2018)

Abstract Background The influence of age on basophils is poorly understood, as well as the effect of aging-associated microbiota on basophils. Therefore, we studied the influence of aging and aging-associated microbiota on basophil frequency and phen

Externí odkaz: https://doaj.org/article/ccd14a573eb448138d6ec74f07f889dd

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Akademický článek

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

Autor: Guoying Zhou, Lisanne Noordam, Dave Sprengers, Michail Doukas, Patrick P. C. Boor, Adriaan A. van Beek, Remco Erkens, Shanta Mancham, Dirk Grünhagen, Anand G. Menon, Johan F. Lange, Pim J. W. A. Burger, Alexandra Brandt, Boris Galjart, Cornelis Verhoef, Jaap Kwekkeboom, Marco J. Bruno

Publikováno v: OncoImmunology, Vol 7, Iss 7 (2018)

Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra-t

Externí odkaz: https://doaj.org/article/860f7b5822ba4d95acd8859e33f3e7a5

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Akademický článek

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

Autor: Floris Fransen, Adriaan A. van Beek, Theo Borghuis, Sahar El Aidy, Floor Hugenholtz, Christa van der Gaast – de Jongh, Huub F. J. Savelkoul, Marien I. De Jonge, Mark V. Boekschoten, Hauke Smidt, Marijke M. Faas, Paul de Vos

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition. However, whether inflammaging is a cause or consequence of an altered

Externí odkaz: https://doaj.org/article/4b89781d37d84a47976bbb1f8cf57c7c

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Akademický článek

The Impact of Gut Microbiota on Gender-Specific Differences in Immunity

Autor: Floris Fransen, Adriaan A. van Beek, Theo Borghuis, Ben Meijer, Floor Hugenholtz, Christa van der Gaast-de Jongh, Huub F. Savelkoul, Marien I. de Jonge, Marijke M. Faas, Mark V. Boekschoten, Hauke Smidt, Sahar El Aidy, Paul de Vos

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Males and females are known to have gender-specific differences in their immune system and gut microbiota composition. Whether these differences in gut microbiota composition are a cause or consequence of differences in the immune system is not known

Externí odkaz: https://doaj.org/article/7a28dc18453d4c6c88fff233769d4cec

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GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells

Autor: Yannick S. Rakké, Lucia Campos Carrascosa, Adriaan A. van Beek, Valeska de Ruiter, Rachelle S. van Gemerden, Michail Doukas, Pascal G. Doornebosch, Maarten Vermaas, Susan ter Borg, Erwin van der Harst, Peter Paul L.O. Coene, Mike Kliffen, Dirk J. Grünhagen, Cornelis Verhoef, Jan N.M. IJzermans, Jaap Kwekkeboom, Dave Sprengers

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, 15(1), 77-97. Elsevier Inc.

BACKGROUND & AIMS: In contrast to mismatch repair deficient colorectal carcinoma (CRC), MMR proficient (pMMR) CRC does not respond to immune checkpoint blockade. We studied immune checkpoint stimulation via glucocorticoid-induced tumor necrosis facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee35edf9632ee9a16ffd8ef605685e30
https://pubmed.ncbi.nlm.nih.gov/36155259

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FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells

Publikováno v: Journal for ImmunoTherapy of Cancer, 8(2):000816. BioMed Central Ltd.
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

BackgroundOX40 (CD134) is a costimulatory molecule of the tumor necrosis factor receptor superfamily that is currently being investigated as a target for cancer immunotherapy. However, despite promising results in murine tumor models, the clinical ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3767bcd457655fb8a2181aa857e8ae
https://pure.eur.nl/en/publications/e71ad835-6f0e-4dad-86a9-c7b601739007

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