Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Adria E. Colletti"'
Autor:
Bradley K. Wong, Yun Ling, Adria E. Colletti, Liyue Huang, Jonathan Roberts, Eskouhie Tchaparian, Xuhai Be, Meghan Langley, Lixia Jin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:316-324
This study was designed to characterize breast cancer resistance protein (Bcrp) knockout Abcg2(-/-) rats and assess the effect of ATP-binding cassette subfamily G member 2 (Abcg2) deletion on the excretion and pharmacokinetic properties of probe subs
Autor:
Min-Hwa Jasmine Lin, Zhiyang Zhao, Jingzhou Liu, L. Steven Hollis, Adria E. Colletti, Yohannes Teffera, Deborah Choquette
Publikováno v:
Chemical Research in Toxicology. 23:1743-1752
Compound 1, (7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine) is a potent, selective inhibitor of c-Met (mesenchymal-epithelial transition factor), a receptor tyrosine kinase that is oft
Autor:
Matthew Peterson, Adria E. Colletti, Eric J. Munson, Mary K. Stanton, Y.-H. Kiang, John Roberts, Mary C. Wells, Meghan Langley, Ron C. Kelly
Publikováno v:
Journal of Pharmaceutical Sciences. 99:3769-3778
The dissolution and pharmacokinetics (PK) of two carboxylic acid co-crystals (cinnamic acid and benzoic acid) with the corresponding amide co-crystals (cinnamamide and benzamide) of AMG 517 were investigated. Powder and intrinsic dissolution studies
Autor:
Harmange Jean-Christophe, Brian K. Albrecht, Alessandro Boezio, Jingzhou Liu, Zhiyang Zhao, L. Steven Hollis, Yohannes Teffera, Adria E. Colletti
Publikováno v:
Chemical Research in Toxicology. 21:2216-2222
AMG 458 {1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide} is a potent, selective inhibitor of c-Met, a receptor tyrosine kinase that is often deregulated in canc
Autor:
Adria E. Colletti, Yohannes Teffera, Zhiyang Zhao, Paul Krolikowski, Jingzhou Liu, Loren Berry
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(4)
The mammalian target of rapamycin (mTOR) is a protein kinase that shows key involvement in age-related disease and promises to be a target for treatment of cancer. In the present study, the elimination of potent ATP-competitive mTOR inhibitor 3-(6-am
Publikováno v:
Journal of Applied Physiology. 86:592-597
In certain conditions, renal prostaglandins (PGs) are important determinants of kidney function. Under these “renal PG-dependent states,” pharmacological inhibition of vasodilatory PG may result in excessive renal vasoconstriction and adversely a
Autor:
Alan C. Cheng, Ti Cai, Barbara Grubinska, Daniel S. La, Tammy L. Bush, Yohannes Teffera, Joseph L. Kim, Christiane Boezio, Michele Potashman, Russell Graceffa, Erin L. Mullady, Paul S. Andrews, James R. Coats, Katrina W. Copeland, Alessandro Boezio, Emily A. Peterson, Richard T. Lewis, John Stellwagen, Jingzhou Liu, Deborah Choquette, Karina Romero, Adria E. Colletti, Shuyan Yi, Mary K. Stanton, Paul L. Shaffer, Michelle DuPont
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(15)
mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to disc
Autor:
Philip R. Olivieri, Barbara Grubinska, Alan C. Cheng, Alessandro Boezio, Katrina W. Copeland, Yohannes Teffera, Daniel S. La, Xuhai Be, James R. Coats, Paul S. Andrews, Jean-Christophe Harmange, Joseph L. Kim, Ti Cai, Emily A. Peterson, Michelle DuPont, Douglas A. Whittington, Laurie B. Schenkel, Adria E. Colletti, Mary K. Stanton, Tammy L. Bush, Russell Graceffa, Erin L. Mullady
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(7)
mTOR is part of the PI3K/AKT pathway and is a central regulator of cell growth and survival. Since many cancers display mutations linked to the mTOR signaling pathway, mTOR has emerged as an important target for oncology therapy. Herein, we report th
Autor:
Danielle M. Zurcher, Daniel Waldon, Katrina W. Copeland, Jingzhou Liu, Adria E. Colletti, Yohannes Teffera, Zhiyang Zhao
Publikováno v:
Chemical research in toxicology. 23(12)
High-resolution accurate MS with an LTQ-Orbitrap was used to identify quinone imine metabolites derived from the 5-hydroxy (5-OH) and 4 prime-hydroxy (4'-OH) glutathione conjugates of diclofenac in rat bile. The initial quinone imine metabolites form
Autor:
Daniel J. Waldon, Yohannes Teffera, Adria E. Colletti, Jingzhou Liu, Danielle Zurcher, Katrina W. Copeland, Zhiyang Zhao
Publikováno v:
Chemical Research in Toxicology; Dec2010, Vol. 23 Issue 12, p1947-1953, 7p