Výsledky vyhledávání - "Adri Zevenbergen"

Akademický článek

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.

Autor: Marvin M van Luijn, Arjan A van de Loosdrecht, Margit H Lampen, Peter A van Veelen, Adri Zevenbergen, Michel G D Kester, Arnoud H de Ru, Gert J Ossenkoppele, Thorbald van Hall, S Marieke van Ham

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34649 (2012)

Antigen presentation by HLA class I (HLA-I) and HLA class II (HLA-II) complexes is achieved by proteins that are specific for their respective processing pathway. The invariant chain (Ii)-derived peptide CLIP is required for HLA-II-mediated antigen p

Externí odkaz: https://doaj.org/article/c4a5eb86be014846968ef1aa4463edb1

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Akademický článek

Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome

Autor: Martine E.D. Chamuleau, Theresia M. Westers, Linda van Dreunen, Judith Groenland, Adri Zevenbergen, Corien M. Eeltink, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht

Publikováno v: Haematologica, Vol 94, Iss 4 (2009)

Background An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified. On the one hand an activated and skewed T-cell repertoire has been

Externí odkaz: https://doaj.org/article/d8cce6d5de1e4ecfacffca1af507e296

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Akademický článek

High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome

Autor: Martine E.D. Chamuleau, Arjan A. van de Loosdrecht, Corine J. Hess, Jeroen J.W.M. Janssen, Adri Zevenbergen, Ruud Delwel, Peter J.M. Valk, Bob Löwenberg, Gert J. Ossenkoppele

Publikováno v: Haematologica, Vol 93, Iss 12 (2008)

Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression. Rec

Externí odkaz: https://doaj.org/article/5ddbe106a6d043fabeed84bdabe498e6

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Supplementary Figure 1 from Absence of Class II–Associated Invariant Chain Peptide on Leukemic Blasts of Patients Promotes Activation of Autologous Leukemia-Reactive CD4+ T Cells

Autor: Arjan A. van de Loosdrecht, S. Marieke van Ham, Gert J. Ossenkoppele, Theresia M. Westers, Adri Zevenbergen, Martine E.D. Chamuleau, Willemijn van den Ancker, Marvin M. van Luijn

Supplementary Figure 1 from Absence of Class II–Associated Invariant Chain Peptide on Leukemic Blasts of Patients Promotes Activation of Autologous Leukemia-Reactive CD4+ T Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5070ca928b1d1b1945b9bb42ae9f2a90
https://doi.org/10.1158/0008-5472.22390910.v1

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Data from Absence of Class II–Associated Invariant Chain Peptide on Leukemic Blasts of Patients Promotes Activation of Autologous Leukemia-Reactive CD4+ T Cells

Autor: Arjan A. van de Loosdrecht, S. Marieke van Ham, Gert J. Ossenkoppele, Theresia M. Westers, Adri Zevenbergen, Martine E.D. Chamuleau, Willemijn van den Ancker, Marvin M. van Luijn

Immune escape in cancer poses a substantial obstacle to successful cancer immunotherapy. Multiple defects in HLA class I antigen presentation exist in cancer that may contribute to immune escape, but less is known about roles for HLA class II antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd7275abb8c2f0f40d63049f78775b95
https://doi.org/10.1158/0008-5472.c.6503099.v1

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Absence of Class II-Associated Invariant Chain Peptide on Leukemic Blasts of Patients Promotes Activation of Autologous Leukemia-Reactive CD4(+) T Cells

Autor: Willemijn van den Ancker, S. Marieke van Ham, Marvin M. van Luijn, Arjan A. van de Loosdrecht, Adri Zevenbergen, Gert J. Ossenkoppele, Theresia M. Westers, Martine E.D. Chamuleau

Publikováno v: Cancer research, 71(7), 2507-2517. American Association for Cancer Research Inc.
Cancer Research, 71(7), 2507-2517. American Association for Cancer Research Inc.
van Luijn, M M, van den Ancker, W, Chamuleau, M E D, Zevenbergen, A, Westers, T M, Ossenkoppele, G J, van Ham, S M & van de Loosdrecht, A A 2011, ' Absence of Class II-Associated Invariant Chain Peptide on Leukemic Blasts of Patients Promotes Activation of Autologous Leukemia-Reactive CD4(+) T Cells ', Cancer Research, vol. 71, no. 7, pp. 2507-2517 . https://doi.org/10.1158/0008-5472.CAN-10-3689

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9be8bd3ac7b2140c496b5e7f40a564c
https://doi.org/10.1158/0008-5472.can-10-3689

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Alternative Ii-independent antigen-processing pathway in leukemic blasts involves TAP-dependent peptide loading of HLA class II complexes

Autor: Suzanne Ostrand-Rosenberg, Maaike E. Ressing, S. Marieke van Ham, Adri Zevenbergen, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, Emmanuel J. H. J. Wiertz, Martine E.D. Chamuleau, Marvin M. van Luijn, Yuri Souwer

Publikováno v: Cancer immunology and immunotherapy, 59(12), 1825-1838. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy, 59(12), 1825-1838
van Luijn, M M, Chamuleau, M E D, Ressing, M E, Wiertz, E J, Ostrand-Rosenberg, S, Souwer, Y, Zevenbergen, A, Ossenkoppele, G J, van de Loosdrecht, A A & van Ham, S M 2010, ' Alternative Ii-independent antigen-processing pathway in leukemic blasts involves TAP-dependent peptide loading of HLA class II complexes ', Cancer Immunology and Immunotherapy, vol. 59, no. 12, pp. 1825-1838 . https://doi.org/10.1007/s00262-010-0908-z
Cancer Immunology and Immunotherapy, 59(12), 1825-1838. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer immunology, immunotherapy, 59(12), 1825-1838. Springer Science and Business Media Deutschland GmbH

During HLA class II synthesis in antigen-presenting cells, the invariant chain (Ii) not only stabilizes HLA class II complexes in the endoplasmic reticulum, but also mediates their transport to specialized lysosomal antigen-loading compartments terme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b6c04f972d97c0da8b53463a53f25f
https://doi.org/10.1007/s00262-010-0908-z

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Combining counterflow centrifugal elutriation and glycoprotein lb-dependent purification of human megakaryocytes: Efficacy and selectivity

Autor: Adri Zevenbergen, Gert J. Ossenkoppele, B. J. M. Geel, Mart M. A. C. Langenhuijsen, F. Rodriguez, Peter C. Huijgens, P. W. Wijermans, Elisabeth C.M. van Pampus

Publikováno v: European Journal of Haematology. 47:299-304

To estimate the efficacy of human megakaryocyte purification techniques, mixtures of known numbers of megakaryocytes with a known ploidy range and of bone marrow or peripheral blood mononuclear cells were made. These artificial bone marrow samples we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebd889f1b9cf10330649ff86cdc3ad6
https://doi.org/10.1111/j.1600-0609.1991.tb01575.x

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Influence of aspirin on human megakaryocyte prostaglandin synthesis

Autor: P. C. Huijgens, Mart M. A. C. Langenhuijsen, E. C. M. Van Pampus, G.J. van Kamp, Adri Zevenbergen, H. Twaalfhoven

Publikováno v: European Journal of Haematology. 50:264-268

To evaluate whether currently popular aspirin regimens have an effect on the prostaglandin synthesis in human megakaryocytes we measured thromboxane B2 (TXB2) synthesis in response to thrombin stimulation in human megakaryocytes ex vivo. Human megaka

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5400c8db266d28371d97e797afdab4
https://doi.org/10.1111/j.1600-0609.1993.tb00160.x

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