Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Adrián E. Granada"'
Autor:
Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes H. Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administrati
Externí odkaz:
https://doaj.org/article/7f9b4ff997de4ecbb614a0fa51da477c
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Cells must accurately and quickly detect DNA damage through a set of checkpoint mechanisms that enable repair and control proliferation. Heterogeneous levels of cellular stress and noisy signaling processes can lead to phenotypic variability
Externí odkaz:
https://doaj.org/article/515cf06ef05642a1b35c6a797fecb919
Autor:
Christian H. Gabriel, Marta del Olmo, Amin Zehtabian, Marten Jäger, Silke Reischl, Hannah van Dijk, Carolin Ulbricht, Asylkhan Rakhymzhan, Thomas Korte, Barbara Koller, Astrid Grudziecki, Bert Maier, Andreas Herrmann, Raluca Niesner, Tomasz Zemojtel, Helge Ewers, Adrián E. Granada, Hanspeter Herzel, Achim Kramer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Live-cell recordings have been an important tool for studying circadian rhythms. Here the authors use CRISPR gene editing mediated knock-in to fluorescently tag Per2 and Cry1, and study cellular circadian dynamics of these two clock proteins.
Externí odkaz:
https://doaj.org/article/b3b650cbf5af40ee9a15a843fab1524b
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2482
Experiments that compare rhythmic properties across different genetic alterations and entrainment conditions underlie some of the most important breakthroughs in circadian biology. A robust estimation of the rhythmic properties of the circadian signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7ac59a3887a6ce29fa3171a7858e1cd
https://pubmed.ncbi.nlm.nih.gov/35610418
https://pubmed.ncbi.nlm.nih.gov/35610418
Autor:
Nils Blüthgen, Galit Lahav, Alba Jiménez, Adrián E. Granada, Ashwini Jambhekar, Jacob Stewart-Ornstein, Simone Reber
Publikováno v:
Molecular Biology of the Cell
DNA-damaging chemotherapeutics are widely used in cancer treatments, but for solid tumors they often leave a residual tumor-cell population. Here we investigated how cellular states might affect the response of individual cells in a clonal population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65b48bd7e0d0a7f20604bc312353e82
https://doi.org/10.1091/mbc.e19-09-0515
https://doi.org/10.1091/mbc.e19-09-0515
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622483
Experiments that compare rhythmic properties across different genetic alterations and entrainment conditions underlie some of the most important breakthroughs in circadian biology. A robust estimation of the rhythmic properties of the circadian signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3dee59e353379d34879124c9944c518
https://doi.org/10.1007/978-1-0716-2249-0_3
https://doi.org/10.1007/978-1-0716-2249-0_3
Methods for the quantification of rhythmic biological signals have been essential for the discovery of function and design of biological oscillators. Advances in live measurements have allowed recordings of unprecedented resolution revealing a new wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a843e91d3a875b9cb6d7a16ca7021dc9
https://doi.org/10.1101/2020.04.29.067744
https://doi.org/10.1101/2020.04.29.067744
Autor:
Achim Kramer, Barbara Koller, Hannah van Dijk, Bert Maier, Amin Zehtabian, Astrid Grudziecki, Helge Ewers, Adrián E. Granada, Silke Reischl, Hanspeter Herzel, Christian H. Gabriel, Marta del Olmo
The current model of the mammalian circadian oscillator is predominantly based on data from genetics and biochemistry experiments, while the cell biology of circadian clocks is still in its infancy. Here, we describe a new strategy for the efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020091449d7065c02a20beb9d4bf28fe
Publikováno v:
SSRN Electronic Journal.
Methods for the quantification of rhythmic biological signals have been essential for the discovery of function and design of biological oscillators. Advances in live measurements have allowed recordings of unprecedented resolution revealing a new wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::157103c55cc2a94a49e3d68620ec839a
https://doi.org/10.2139/ssrn.3748561
https://doi.org/10.2139/ssrn.3748561
Publikováno v:
Information-and Communication Theory in Molecular Biology ISBN: 9783319547282
Most species evolved a circadian clock to adapt to the 24 h period of the solar day. In mammals, these clocks generate endogenous rhythms by regulatory gene networks in almost every cell. A pacemaker, the suprachiasmatic nucleus (SCN) as the master c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca09ae307a3d76c22675687ecfa99dd
https://doi.org/10.1007/978-3-319-54729-9_11
https://doi.org/10.1007/978-3-319-54729-9_11