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Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids

Autor: Marie-Christin Jäger, Víctor González-Ruiz, Friedrich L. Joos, Denise V. Winter, Julien Boccard, Thorsten Degenhardt, Steve Brand, Serge Rudaz, George R. Thompson, Alex Odermatt

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

The triazole antifungals posaconazole and itraconazole can cause pseudohyperaldosteronism with hypertension and hypokalemia, edema, and gynecomastia by inhibiting steroid synthesis and metabolism. Mechanisms underlying pseudohyperaldosteronism includ

Externí odkaz: https://doaj.org/article/afe101840dac4196825e2d8599c4e6ac

Corrigendum to "Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19" [Metabolism volume 160 (2024) 155980].

Autor: Wen TZ; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Li TR; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Chen XY; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Chen HY; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Wang S; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Fu WJ; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Xiao SQ; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Luo J; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Huang JF; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Tang R; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., He ZC; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Luo T; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Zhao HL; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Chen C; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Miao JY; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Niu Q; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China., Wang Y; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China; Jinfeng Laboratory, Chongqing, China., Bian XW; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China; YuYue Laboratory, Chongqing, China. Electronic address: bianxiuwu@263.net., Yao XH; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China. Electronic address: yxh15@163.com.

Publikováno v: Metabolism: clinical and experimental [Metabolism] 2024 Dec; Vol. 161, pp. 156033. Date of Electronic Publication: 2024 Oct 04.

Updates in adrenal steroidogenesis inhibitors for Cushing’s syndrome – A practical guide

Autor: Varlamov, Elena V., Han, Ashley J., Fleseriu, Maria

Publikováno v: In Best Practice & Research Clinical Endocrinology & Metabolism January 2021 35(1)