Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Adozelesin"'
Autor:
J. Carlos Menéndez, Carmen Avendaño
Publikováno v:
Medicinal Chemistry of Anticancer Drugs ISBN: 9780128185490
This chapter study the characteristics and types of minor groove binders. The in situ bioreductive activation leading to a cytotoxic species, which is the main mechanism of action of mitomycin C, is studied in detail. The bioactivation mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af526e01373ada9690d8802b0d1d9b72
https://doi.org/10.1016/b978-0-12-818549-0.00020-0
https://doi.org/10.1016/b978-0-12-818549-0.00020-0
Akademický článek
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Autor:
Andrew S. Thompson, Suzanne R. Hopton
Publikováno v:
Biochemistry. 50:4143-4154
Previous structural studies of the cyclopropapyrroloindole (CPI) antitumor antibiotics have shown that these ligands bind covalently edge-on into the minor groove of double-stranded DNA. Reversible covalent modification of the DNA via N3 of adenine o
Publikováno v:
Pharmacogenomics. 8:1267-1272
Evaluation of: Woynarowski JM, Krugliak M, Ginsburg H: Pharmacogenomic analyses of targeting the AT-rich malaria parasite genome with AT-specific alkylating drugs. Mol. Biochem. Parasitol. 154(1), 70–81 (2007) [1] . The sequencing of the malaria ge
Publikováno v:
Molecular and Biochemical Parasitology. 154:70-81
Human malaria parasites, including the most lethal Plasmodium falciparum , are increasingly resistant to existing antimalarial drugs. One remarkable opportunity to selectively target P. falciparum stems from the unique AT-richness of its genome (80%
Publikováno v:
Journal of Molecular Biology. 361:898-919
To understand how bulky adducts might perturb DNA helicase function, three distinct DNA-binding agents were used to determine the effects of DNA alkylation on a DNA helicase. Adozelesin, ecteinascidin 743 (Et743) and hedamycin each possess unique str
Publikováno v:
Molecular and Biochemical Parasitology. 148:52-59
There is an urgent need for new anti-malarial drugs to combat the resurgence of resistance to current therapies. To exploit the A/T richness of malaria DNA as a potential target for anti-malarial drugs we tested an A/T-specific DNA synthesis inhibito
Autor:
John David Trzupek, Moses Lee, James L. Toth, William T. Pennington, Lloyd V. Flores, Konstantinos Kiakos, John A. Hartley
Publikováno v:
Medicinal Chemistry. 1:13-19
The design, synthesis and DNA binding properties of a novel achiral and amino-containing seco-cyclopropylindoline analog (seco-amino-CI-TMI, 1) of the duocarmycins are described. Thermal induced DNA cleavage studies on pUC18 DNA revealed compound 1 t
Akademický článek
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Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 532:215-226
To better understand the different cellular responses to replication fork pausing versus blockage, early DNA damage response markers were compared after treatment of cultured mammalian cells with agents that either inhibit DNA polymerase activity (hy