Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Adovi Akue"'
Autor:
Robert J. Dorosky, Jeremy E. Schreier, Stephanie L. Lola, Rosa L. Sava, Michael P. Coryell, Adovi Akue, Mark KuKuruga, Paul E. Carlson, Sheila M. Dreher-Lesnick, Scott Stibitz
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Nanobodies are highly specific binding domains derived from naturally occurring single chain camelid antibodies. Live biotherapeutic products (LBPs) are biological products containing preparations of live organisms, such as Lactobacillus, th
Externí odkaz:
https://doaj.org/article/7cd372ca8a2e40b3a7ac94c9591b6358
Autor:
Andrew M Lewis, Gideon Foseh, Wei Tu, Keith Peden, Adovi Akue, Mark KuKuruga, Daniel Rotroff, Gladys Lewis, Ilya Mazo, Steven R Bauer
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0293406 (2023)
The AGMK1-9T7 cell line has been used to study neoplasia in tissue culture. By passage in cell culture, these cells evolved to become tumorigenic and metastatic in immunodeficient mice at passage 40. Of the 20 x 106 kidney cells originally plated, le
Externí odkaz:
https://doaj.org/article/de997a3a85884fda8da535cf8cfeb3e0
Autor:
Parna Bhattacharya, Sreenivas Gannavaram, Nevien Ismail, Ankit Saxena, Pradeep K. Dagur, Adovi Akue, Mark KuKuruga, Hira L. Nakhasi
Publikováno v:
Pathogens, Vol 12, Iss 4, p 534 (2023)
No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted L. donovani (LdCen−/−) parasite vaccine has been shown to induce robust innate immunity and provide protection in animal models. Toll-like recepto
Externí odkaz:
https://doaj.org/article/ce954f59d47649aeac64fc072e4e623b
Autor:
Parna Bhattacharya, Nevien Ismail, Ankit Saxena, Sreenivas Gannavaram, Ranadhir Dey, Timur Oljuskin, Adovi Akue, Kazuyo Takeda, James Yu, Subir Karmakar, Pradeep K Dagur, John Philip McCoy, Hira L Nakhasi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 2, p e0010224 (2022)
BackgroundNeutrophils are involved in the initial host responses to pathogens. Neutrophils can activate T cell responses either independently or through indirect involvement of Dendritic cells (DCs). Recently we have demonstrated direct neutrophil-T
Externí odkaz:
https://doaj.org/article/2d1df771608e44698a707b8c704a0dad
Autor:
Roberto De Pascalis, Amy P Rossi, Lara Mittereder, Kazuyo Takeda, Adovi Akue, Sherry L Kurtz, Karen L Elkins
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237034 (2020)
Production of IFN-γ is a key innate immune mechanism that limits replication of intracellular bacteria such as Francisella tularensis (Ft) until adaptive immune responses develop. Previously, we demonstrated that the host cell types responsible for
Externí odkaz:
https://doaj.org/article/a2ed8fdb6e5040ad9e4817799e1499a2
Autor:
Marcela Parra, Megan Weitner, Amy Yang, Adovi Akue, Xia Liu, Thomas Schmidt, Windy R Allman, Mustafa Akkoyunlu, Steven C Derrick
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238493 (2020)
To better understand anti-malaria protective immune responses, we examined the cellular mechanisms that govern protective immunity in a murine Plasmodium yoelii 17X NL (PyNL) re-infection model. Initially, we confirmed that immune B cells generated d
Externí odkaz:
https://doaj.org/article/8d120fb6b5b741499b1a91dbcc7fed97
Autor:
Taylor A. Harper, Silvia M. Bacot, Christie Jane Fennell, Rebecca L. Matthews, Christina Zhu, Peng Yue, Alexander Benton, Devira Friedman, Adovi Akue, Mark A. KuKuruga, Shiowjen Lee, Tao Wang, Gerald M. Feldman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11848 (2021)
Immune checkpoint inhibitor (ICI) therapy has revolutionized anti-cancer treatment for many late-stage cancer patients. However, ICI therapy has thus far demonstrated limited efficacy for most patients, and it remains unclear why this is so. Interleu
Externí odkaz:
https://doaj.org/article/593e5988af814e43a4f69208f2a1b7c8
Autor:
Peng Yue, Taylor Harper, Silvia M. Bacot, Monica Chowdhury, Shiowjen Lee, Adovi Akue, Mark A. Kukuruga, Tao Wang, Gerald M. Feldman
Publikováno v:
OncoImmunology, Vol 8, Iss 1 (2019)
Immune checkpoint inhibitors (ICIs) such as the anti-PD-1 antibody Nivolumab, achieve remarkable clinical efficacy in patients with late stage cancers. However, only a small subset of patients benefit from this therapy. Numerous clinical trials are u
Externí odkaz:
https://doaj.org/article/371c9dae9a2948adab855ac32f0cc9b9
Autor:
Silvia M. Bacot, Taylor A. Harper, Rebecca L. Matthews, Christie Jane Fennell, Adovi Akue, Mark A. KuKuruga, Shiowjen Lee, Tao Wang, Gerald M. Feldman
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9023 (2020)
The absence of reliable, robust, and non-invasive biomarkers for anti- Programmed cell death protein 1 (PD-1) immunotherapy is an urgent unmet medical need for the treatment of cancer patients. No predictive biomarkers have been established based on
Externí odkaz:
https://doaj.org/article/ec0c6f66aa864bccaacb4729e00af4a1
Autor:
Miranda S Oakley, Joanna K Chorazeczewski, Maya Aleshnick, Vivek Anantharaman, Victoria Majam, Bhavna Chawla, Timothy G Myers, Qin Su, Winter A Okoth, Kazuyo Takeda, Adovi Akue, Mark KuKuruga, L Aravind, Sanjai Kumar
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201043 (2018)
Macrophages express a wide array of invariant receptors that facilitate host defense and mediate pathogenesis during pathogen invasion. We report on a novel population of CD11bhighCD14+F4/80+ macrophages that express TCRβ. This population expands dr
Externí odkaz:
https://doaj.org/article/d11403876389432dbbf5a9e4209c03f2