Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Adorjan Aszalos"'
Autor:
Adorjan Aszalos
Publikováno v:
Current Drug Metabolism. 9:1010-1018
Medicinal use of natural products such as extracts of plants has existed for many years in China and in other countries and they are now available worldwide. Citrus fruit juices are consumed on a daily basis around the world. Modern medicine provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e315e967c16904029016b4ca97f4172
https://doi.org/10.2174/138920008786927776
https://doi.org/10.2174/138920008786927776
Autor:
Adorjan Aszalos, Jun-Jie Yin, Ding Wu Shen, Michael M. Gottesman, Toren Finkel, Xing-Jie Liang
Publikováno v:
Molecular Cancer Research. 6:1499-1506
Tumors frequently develop resistance to cisplatin, a platinum drug used as a cornerstone of present-day chemotherapy regimens, significantly decreasing its usefulness in the clinic. Although it is known that cisplatin-resistant (CP-r) cancer cells co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ded12dd9b590cc7233ee73a4e68ada
https://doi.org/10.1158/1541-7786.mcr-07-2130
https://doi.org/10.1158/1541-7786.mcr-07-2130
Autor:
Adorjan Aszalos
Publikováno v:
Drug Discovery Today. 12:833-837
The simultaneous use of several drugs (polypharmacy) for the treatment of cancer, HIV, and other diseases and for multiple ailments of the elderly is a common practice in modern medicine. Co-administration of drugs may result in unwanted side effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620b686f67f83b4565299b63336d9b16
https://doi.org/10.1016/j.drudis.2007.07.022
https://doi.org/10.1016/j.drudis.2007.07.022
Publikováno v:
Acta Microbiologica et Immunologica Hungarica. 52:407-432
The relationship of plasma membrane biophysical properties to the anti-proliferative effect of interferon-alpha (IFN-alpha) was investigated in Daudi lymphoblasts cell lines with sensitivity to growth inhibition, parallel clonal variants selected for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9c438fdf035c716fd5e818eda10855
https://doi.org/10.1556/amicr.52.2005.3-4.12
https://doi.org/10.1556/amicr.52.2005.3-4.12
Autor:
Raynard Forte, Barbara J. Taylor, Adorjan Aszalos, Michael M. Gottesman, Jien-Wei Zhou, Jun-Jie Yin, Michael P. Kozar, Xing-Jie Liang, Paul C. Wang, Carol O. Cardarelli
Publikováno v:
Experimental Cell Research. 293:283-291
The mechanism of resistance of cancer cells to the anticancer drug cisplatin is not fully understood. Using cisplatin-sensitive KB-3-1 and -resistant KCP-20 cells, we found that the resistant cells have higher membrane potential, as determined by mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5254cb3a5356961da12e8c8b27e573c
https://doi.org/10.1016/j.yexcr.2003.10.012
https://doi.org/10.1016/j.yexcr.2003.10.012
Publikováno v:
Cancer Letters. 167:157-162
The application of most agents with the capacity to reverse multidrug resistance (MDR) via modulation of the multidrug transporter P-glycoprotein (Pgp) was shown to be associated with toxic side-effects. For this reason, we have investigated the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17c5508e13cebf1416b52fbfb2b679e
https://doi.org/10.1016/s0304-3835(01)00488-8
https://doi.org/10.1016/s0304-3835(01)00488-8
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 423:153-159
The antiviral mechanism of action of the polysulfonated azo-dyes is discussed in this paper. Crucial to the antiviral activity of these dyes is the inhibition of the HIV entry into the host cell. This is a result of the covering strategic areas of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66f33dd0ebadf3970051b9c93531ee22
https://doi.org/10.1016/s0166-1280(97)00363-1
https://doi.org/10.1016/s0166-1280(97)00363-1
Autor:
Syed N. Alam, John J. Jessop, Adorjan Aszalos, Kenneth L. Hastings, Chang-Ho Ahn, Young S. Choi, James L. Weaver
Publikováno v:
Drug Information Journal. 31:1357-1361
Determination of the potential for an investigational drug to adversely affect the immune system is a standard component of nonclinical toxicology studies. Potential adverse immune effects include ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b38a49199f2ab018597f4eebe78bd9
https://doi.org/10.1177/009286159703100438
https://doi.org/10.1177/009286159703100438
Autor:
Myung-Sil Hwang, P. Scott Pine, Christine A. Hrycyna, Adorjan Aszalos, Thomas Licht, Chang-Ho Ahn, Jun-Jie Yin
Publikováno v:
International Journal of Cancer. 65:389-397
Pharmacologically active in vivo doses of P-glycoprotein (Pgp) blockers, specifically verapamil, Cremophor EL and PSC833 cause toxicity in addition to that from the concomitantly used cancer chemotherapeutic drugs. It was shown before that these bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71f348852d6159cbffa41361470aed6c
https://doi.org/10.1002/(sici)1097-0215(19960126)65:3<389::aid-ijc19>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19960126)65:3<389::aid-ijc19>3.0.co