Zobrazeno 1 - 10 of 82 pro vyhledávání: '"Adoración G. Quiroga"'
1
Akademický článek
Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells
Autor: Jorge Melones-Herrero, Sonia Alcalá, Laura Ruiz-Cañas, Carlos Benítez-Buelga, Sandra Batres-Ramos, Carmela Calés, Oscar Lorenzo, Rosario Perona, Adoración G. Quiroga, Bruno Sainz, Isabel Sánchez-Pérez
Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Cisplatin-based chemotherapy has associated clinical disadvantages, such as high toxicity and resistance. Thus, the development of new antitumor metallodrugs able to overcome different clinical barriers is a public healthcare priority. Here,
Externí odkaz: https://doaj.org/article/3950323370b4436097434ef697f118ef
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3
Akademický článek
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools
Autor: Sandra Muñoz-Galván, Blanca Felipe-Abrio, Miguel García-Carrasco, Julia Domínguez-Piñol, Elisa Suarez-Martinez, Eva M. Verdugo-Sivianes, Asunción Espinosa-Sánchez, Lola E. Navas, Daniel Otero-Albiol, Juan J. Marin, Manuel P. Jiménez-García, Jose M. García-Heredia, Adoración G. Quiroga, Purificacion Estevez-Garcia, Amancio Carnero
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response probability to subsequen
Externí odkaz: https://doaj.org/article/12556c9773934197bdfe15b251bd3b2e
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5
Chemical and Biological Evaluation of Thiosemicarbazone-Bearing Heterocyclic Metal Complexes
Autor: Jorge M. Herrero, Adoración G. Quiroga, Ana I. Matesanz
Publikováno v: Current Topics in Medicinal Chemistry. 21:59-72
Thiosemicarbazones (TSCNs) constitute a broad family of compounds (R1R2C=N-NH-C(S)- NR3R4), particularly attractive because many of them display some biological activity against a wide range of microorganisms and cancer cells. Their activity can be r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a75bceb12bd4d0da8fc733e4b6e332f
https://doi.org/10.2174/1568026620666201022144004
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6
Thiosemicarbazone Derivatives as Inhibitors of Amyloid-β Aggregation: Effect of Metal Coordination
Autor: Ana I. Matesanz, Carmen Lorenzo, Raimon Sabaté, Alba Espargaró, Ana B. Caballero, Adoración G. Quiroga, Patrick Gamez
Publikováno v: Inorganic Chemistry. 59:6978-6987
Three thiosemicarbazone derivatives, namely 4-(dimethylamino)benzaldehyde 4,4-dimethylthiosemicarbazone (HL1), 4-(dimethylamino)benzaldehyde thiosemicarbazone (HL2), and 4-(dimethylamino)benzaldehy...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93afb77350de01dc2de37e5f3db138b7
https://doi.org/10.1021/acs.inorgchem.0c00467
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7
New Platinum(II) Triazole Thiosemicarbazone Complexes: Analysis of Their Reactivity and Potential Antitumoral Action
Autor: Eva J Faraco, Ana I. Matesanz, Leticia Cubo, Jorge M. Herrero, Adoración G. Quiroga
Publikováno v: ChemBioChem. 21:1226-1232
The synthesis and characterization of three new platinum complexes, with 3,5-diacetyl-1,2,4-triazole bis(4-N-isopropylthiosemicarbazone) as a ligand, are reported. The specific conditions under which solvent coordination takes place are reported and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb7dca8cfc2a510999de72d24c532a3
https://doi.org/10.1002/cbic.201900545
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8
Novel structures of platinum complexes bearing N‑bisphosphonates and study of their biological properties
Autor: Célia Fernandes, Filipa Mendes, Josefina Perles, Ana I. Matesanz, Amparo Alvarez-Valdés, Adoración G. Quiroga, João D. G. Correia
Publikováno v: Journal of Inorganic Biochemistry. 191:112-118
Novel bisphosphonate platinum complexes: [Pt(isopropylamine) 2 (BP)]NO 3 (BP = pamidronate and alendronate) have been synthesized and characterized. Their monomeric structure contains a bisphosphonate acting as chelate ligand through its oxygen atom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9b4f54d80f17931a71689ebe3b0892
https://doi.org/10.1016/j.jinorgbio.2018.11.010
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9
Combining imaging and anticancer properties with new heterobimetallic Pt(ii)/M(i) (M = Re, 99mTc) complexes
Autor: Huaiyi Huang, Gilles Gasser, Filipa Mendes, Amparo Alvarez-Valdés, Letícia Quental, António Paulo, Adoración G. Quiroga, Riccardo Rubbiani, Paula D. Raposinho, Carmen Navarro-Ranninger, Hui Chao, Isabel Santos
Publikováno v: Dalton Transactions. 46:14523-14536
In this article, we report on the development of new metal-based anticancer agents with imaging, chemotherapeutic and photosensitizing properties. Hence, a new heterobimetallic complex (Pt-LQ-Re) was prepared by connecting a non-conventional trans-ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b11d81c1756f9570635eb8546adbe05
https://doi.org/10.1039/c7dt00043j
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10
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools
Autor: Manuel P. Jiménez-García, Daniel Otero-Albiol, Elisa Suarez-Martinez, Amancio Carnero, Adoración G. Quiroga, Blanca Felipe-Abrio, Asunción Espinosa-Sánchez, Lola E. Navas, Eva M. Verdugo-Sivianes, Julia Domínguez-Piñol, Purificacion Estevez-Garcia, Sandra Muñoz-Galván, Juan Marín, Miguel García-Carrasco, José M. García-Heredia
Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Digital.CSIC. Repositorio Institucional del CSIC
[Background] Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response probability to subsequent lines
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29f9ddcd8136f42d5b5e8b1f491efa2
https://hdl.handle.net/10668/3169
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