Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Adoptive cell therapy (ACT)"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumor-infiltrating lymphocyte (TIL) therapy in adoptive T-cell therapy (ACT) has already caused durable regression in a variety of cancer types due to T-cell persistence, clinical activity, and duration of objective response and safety. TILs
Externí odkaz:
https://doaj.org/article/9ea2ea92a91e4eacbebc1cd27cde25f4
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Malignant melanoma, the most aggressive form of skin cancer, is characterized by unpredictable growth patterns, and its mortality rate has remained alarmingly high over recent decades, despite various treatment approaches. One promising strategy for
Externí odkaz:
https://doaj.org/article/0836652ad0524473ae7c934f3dbd62a3
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cells engineered to express chimeric-antigen receptors (CAR-T cells) can effectively control relapsed and refractory haematological malignancies in the clinic. However, the successes of CAR-T cell therapy have not been recapitulated in solid tumour
Externí odkaz:
https://doaj.org/article/fa242560a31a4b1d922320b9532f4577
Autor:
Joanna Chmiel, Mariusz Stasiak, Maria Skrzypkowska, Lucjan Samson, Piotr Łuczkiewicz, Piotr Trzonkowski
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36512- (2024)
Cellular therapies utilizing regulatory T cells (Tregs) have flourished in the autoimmunity space as a new pillar of medicine. These cells have shown a great promise in the treatment of such devastating conditions as type 1 diabetes mellitus (T1DM),
Externí odkaz:
https://doaj.org/article/719b97bd43d54ce881f54fde55f1c5b9
Autor:
Chmiel, Joanna a, b, ⁎, Stasiak, Mariusz a, b, Skrzypkowska, Maria c, Samson, Lucjan a, b, Łuczkiewicz, Piotr b, Trzonkowski, Piotr c
Publikováno v:
In Heliyon 15 September 2024 10(17)
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Cutaneous melanoma is the deadliest and most aggressive form of skin cancer owing to its high capacity for metastasis. Over the past few decades, the management of this type of malignancy has undergone a significant revolution with the advent of both
Externí odkaz:
https://doaj.org/article/9238a61fdb91425fbe8f88d0e2a82875
Autor:
Mengshi Luo, Wenjian Gong, Yuewen Zhang, Huayi Li, Ding Ma, Kongming Wu, Qinglei Gao, Yong Fang
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-23 (2023)
Abstract T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthrough of chimeric antigen receptor therapy (CAR-T) in hematologic malignancies. It relies on the pool of functional T ce
Externí odkaz:
https://doaj.org/article/e06ce864c10748189c45e05e52da659d
Publikováno v:
Hematology Reports, Vol 15, Iss 4, Pp 608-626 (2023)
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy that is often associated with relapse and drug resistance after standard chemotherapy or targeted therapy, particularly in older patients. Hematopoietic stem cell transplants ar
Externí odkaz:
https://doaj.org/article/8430404a0b2a4e86a3f1e9a0ae2d38ba
Autor:
Sally Taylor, Kate Law, Jake Coomber-Moore, Michelle Davies, Fiona Thistlethwaite, Mel Calvert, Olalekan Aiyegbusi, Janelle Yorke
Publikováno v:
Systematic Reviews, Vol 12, Iss 1, Pp 1-24 (2023)
Abstract Introduction Adoptive cell therapy (ACT) is a rapidly evolving field. Patient-reported outcomes (PROs) allow patients to report the impact of treatment on their quality of life during and after treatment. The systematic review aims to charac
Externí odkaz:
https://doaj.org/article/6f2755b1ddc24d2db741168f88fcafbb
Autor:
Tao Chen, Yucheng Xue, Shengdong Wang, Jinwei Lu, Hao Zhou, Wenkan Zhang, Zhiyi Zhou, Binghao Li, Yong Li, Zenan Wang, Changwei Li, Yinwang Eloy, Hangxiang Sun, Yihang Shen, Mohamed Diaty Diarra, Chang Ge, Xupeng Chai, Haochen Mou, Peng Lin, Xiaohua Yu, Zhaoming Ye
Publikováno v:
Bioactive Materials, Vol 23, Iss , Pp 508-523 (2023)
Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell therapy (ACT) against solid tumors. Here, we present a facile immune cell surface engineering strategy aiming to substantially enhance the anti-tumor ef
Externí odkaz:
https://doaj.org/article/5f5e8f8ff6a1474f944c8a3e823b0570