Zobrazeno 1 - 10
of 1 645
pro vyhledávání: '"Adoptive T-cell therapy"'
Autor:
Jian Liu, Min Wu, Yifan Yang, Xinyu Mei, Liming Wang, Jingyu Wang, Zixuan Wang, Shan He, Hangyu Liu, Han Jiang, Shen Qu, Yuwei Zhang, Ying Chen, Xun Tian, Yafei Huang, Hui Wang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Clinical trials have shown that immunotherapy based on Vγ9Vδ2 T cells (Vδ2 T cells) is safe and well-tolerated for various cancers including cervical cancer (CC), but its overall treatment efficacy remains limited. Therefore, e
Externí odkaz:
https://doaj.org/article/55b102c0746543a88b6f2bc28deb4dd8
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117296- (2024)
Over the past decades, cancer immunotherapy has encountered challenges such as immunogenicity, inefficiency, and cytotoxicity. Consequently, exosome-based cancer immunotherapy has gained rapid traction as a promising alternative. Exosomes, a type of
Externí odkaz:
https://doaj.org/article/9824b21c53a64cf89c4d9f2aa636ac81
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-25 (2024)
Abstract T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different immune challenges dependent on
Externí odkaz:
https://doaj.org/article/151482897f094856a2a5eab46430d9b0
Autor:
Ashwathi Puravankara Menon, Helena Villanueva, Daniel Meraviglia-Crivelli, Hisse M. van Santen, Joschka Hellmeier, Angelina Zheleva, Francesca Nonateli, Timo Peters, Tassilo L.A. Wachsmann, Mercedes Hernandez-Rueda, Johannes B. Huppa, Gerhard J. Schütz, Eva Sevcsik, Beatriz Moreno, Fernando Pastor
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102198- (2024)
The CD3/T cell receptor (TCR) complex is responsible for antigen-specific pathogen recognition by T cells, and initiates the signaling cascade necessary for activation of effector functions. CD3 agonistic antibodies are commonly used to expand T lymp
Externí odkaz:
https://doaj.org/article/6c3ef753dfa94901b0ef2480454cb96e
Autor:
Michael W. Moles, Henry Erdlei, Lutz Menzel, Marialucia Massaro, Agnese Fiori, Mario Bunse, Moritz Schrimpf, Kerstin Gerlach, Venugopal Gudipati, John Reiser, Ketan Mathavan, Jodie P. Goodrich, Johannes B. Huppa, Jan Krönke, Bahram Valamehr, Uta E. Höpken, Armin Rehm
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Multiple myeloma (MM) is a plasma cell disease with a preferential bone marrow (BM) tropism. Enforced expression of tissue-specific chemokine receptors has been shown to successfully guide adoptively-transferred CAR NK cells towards the malignant mil
Externí odkaz:
https://doaj.org/article/2dd8f8910e9849f68e43bc637bdeee21
Autor:
Isabella Elias Yonezawa Ogusuku, Vera Herbel, Simon Lennartz, Caroline Brandes, Eva Argiro, Caroline Fabian, Carola Hauck, Conny Hoogstraten, Sabrina Veld, Lois Hageman, Karin Teppert, Georgia Koutsoumpli, Marieke Griffioen, Nadine Mockel-Tenbrinck, Thomas Schaser, Rosa de Groot, Ian C.D. Johnston, Dominik Lock
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101224- (2024)
Acute myeloid leukemia (AML) is a heterogeneous malignancy that requires further therapeutic improvement, especially for the elderly and for subgroups with poor prognosis. A recently discovered T cell receptor (TCR) targeting mutant nucleophosmin 1 (
Externí odkaz:
https://doaj.org/article/722f01dd698746e597d61bf1c55d549c
Autor:
Vrunda Trivedi, Changlin Yang, Kelena Klippel, Oleg Yegorov, Christina von Roemeling, Lan Hoang-Minh, Graeme Fenton, Elizabeth Ogando-Rivas, Paul Castillo, Ginger Moore, Kaytora Long-James, Kyle Dyson, Bently Doonan, Catherine Flores, Duane A. Mitchell
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Despite advancements in the successful use of immunotherapy in treating a variety of solid tumors, applications in treating brain tumors have lagged considerably. This is due, at least in part, to the lack of well-characterized an
Externí odkaz:
https://doaj.org/article/dd7adebdc5ef44db8761e569a2065eb9
Autor:
Elizabeth E. Sweeney, Palak Sekhri, Nethaji Muniraj, Jie Chen, Sally Feng, Joshua Terao, Samantha J. Chin, Danielle E. Schmidt, Catherine M. Bollard, Conrad Russell Y. Cruz, Rohan Fernandes
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 3, Pp n/a-n/a (2024)
Abstract Prussian blue nanoparticle‐based photothermal therapy (PBNP‐PTT) is an effective tumor treatment capable of eliciting an antitumor immune response. Motivated by the ability of PBNP‐PTT to potentiate endogenous immune responses, we rece
Externí odkaz:
https://doaj.org/article/c5f0a8eec6a54e4d89e45d10ca68fcd8
Autor:
Markus Benedikt Krueger, Agnes Bonifacius, Anna Christina Dragon, Maria Michela Santamorena, Björn Nashan, Richard Taubert, Ulrich Kalinke, Britta Maecker-Kolhoff, Rainer Blasczyk, Britta Eiz-Vesper
Publikováno v:
Transplant International, Vol 37 (2024)
Infectious complications, including widespread human cytomegalovirus (CMV) disease, frequently occur after hematopoietic stem cell and solid organ transplantation due to immunosuppressive treatment causing impairment of T-cell immunity. Therefore, in
Externí odkaz:
https://doaj.org/article/2510528d4a8b4271b8afed71ba6d2b25
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Despite significant progress in targeted therapy for acute myeloid leukemia (AML), clinical outcomes are disappointing for elderly patients, patients with less fit disease characteristics, and patients with adverse disease risk characteristics. Over
Externí odkaz:
https://doaj.org/article/c1327cd8794d4895b9da778ae8835be7