The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

Autor: Saavedra Harold I, Adon Arsene M, Harrison Mary K

Publikováno v: Cell Division, Vol 6, Iss 1, p 2 (2011)

Abstract Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that

Externí odkaz: https://doaj.org/article/f8451bc19312442eb2b518c156edf5cd

The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.

Autor: Harrison, Mary K.¹, Adon, Arsene M.¹, Saavedra, Harold I.¹ hsaaved@emory.edu

Publikováno v: Cell Division. 2011, Vol. 6 Issue 1, p1-13. 13p.

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Correction for Adon et al., "Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells".

Autor: Adon AM; Department of Radiation Oncology, Emory University School of Medicine, 1365C Clifton Rd., Room C3084, Atlanta, Georgia 30322., Zeng X; Department of Radiation Oncology, Emory University School of Medicine, 1365C Clifton Rd., Room C3084, Atlanta, Georgia 30322., Harrison MK; Department of Radiation Oncology, Emory University School of Medicine, 1365C Clifton Rd., Room C3084, Atlanta, Georgia 30322., Sannem S; Department of Radiation Oncology, Emory University School of Medicine, 1365C Clifton Rd., Room C3084, Atlanta, Georgia 30322., Kiyokawa H; Northwestern University, Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Mail Code S215, 303 East Chicago Avenue, Chicago, Illinois 60611-3008., Kaldis P; Institute of Molecular and Cell Biology (IMCB) Cell Division and Cancer Laboratory (PRK), 61 Biopolis Drive, Proteos 3-10B, Singapore 138673, Singapore., Saavedra HI; Department of Radiation Oncology, Emory University School of Medicine, 1365C Clifton Rd., Room C3084, Atlanta, Georgia 30322 hsaavedra@psm.edu.

Publikováno v: Molecular and cellular biology [Mol Cell Biol] 2020 Nov 06; Vol. 40 (23). Date of Electronic Publication: 2020 Nov 06 (Print Publication: 2020).