Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Adolph M. Pietruszkiewicz"'
Autor:
Adolph M. Pietruszkiewicz, William A. Bolhofer, C. N. Habecker, Henry I. Jacoby, M. L. Torchiana, Clement A. Stone
Publikováno v:
Journal of Medicinal Chemistry. 22:295-301
A series of N-substituted 2-mercaptoacetamidines was synthesized and evaluated for gastric antisecretory activity in dogs stimulated with gastrin tetrapeptide. The most potent analogues showed 80--95% inhibition of acid secretion after an oral dose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab794c23208d884fdd9d6ae8ceb2069f
https://doi.org/10.1021/jm00189a015
https://doi.org/10.1021/jm00189a015
Autor:
M. L. Torchiana, William A. Bolhofer, C. N. Habecker, Jacob M. Hoffman, Adolph M. Pietruszkiewicz, Edward J. Cragoe
Publikováno v:
Journal of Medicinal Chemistry. 22:301-306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fec34f0528f62d844e1fd104c0e55c
https://doi.org/10.1021/jm00189a016
https://doi.org/10.1021/jm00189a016
Autor:
D. Szarowski, O. W. Woltersdorf, E. J. Cragoe, J.W. Rose, Adolph M. Pietruszkiewicz, L. R. Nelson, H.K. Kimelberg, A. J. Popp
Publikováno v:
Central Nervous System Trauma. 4:3-14
Cats, injured by a mechanical plus hypoxic model of traumatic brain injury, were treated by intracisternal injection of a modified loop diuretic (L-644,711). This drug inhibits the chloride/bicarbonate anion exchange transport system. The treatment r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f06cd2218bb49432698f05efea6f14f
https://doi.org/10.1089/cns.1987.4.3
https://doi.org/10.1089/cns.1987.4.3
Autor:
Charles N. Habecker, Adolph M. Pietruszkiewicz, Baldwin John J, William A. Bolhofer, Edward J. Cragoe, Brian T. Phillips, William C. Lumma, Jacob M. Hoffman, M. L. Torchiana
Publikováno v:
Journal of Medicinal Chemistry. 26:140-144
Two series of compounds related to cimetidine and tiotidine were synthesized as part of a study to evaluate the importance of conformational parameters in binding at histamine H2 receptors. The flexible methylthioethyl connecting chain was replaced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43aef62d68b6ea27490250f8d4fbbc8
https://doi.org/10.1021/jm00356a005
https://doi.org/10.1021/jm00356a005
Publikováno v:
The Journal of Organic Chemistry. 22:1338-1345
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c19cb4e0a06645739e326ca854fac6f3
https://doi.org/10.1021/jo01362a012
https://doi.org/10.1021/jo01362a012
Publikováno v:
The Journal of Organic Chemistry. 23:971-980
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a67df36f2af2d33f96fd02d7614873
https://doi.org/10.1021/jo01101a009
https://doi.org/10.1021/jo01101a009
Autor:
Gerald E. Stokker, Harold K. Kimelberg, Carl B. Ziegler, Cragoe Edward J, Otto W. Woltersdorf, N. P. Gould, Bourke Rs, Adolph M. Pietruszkiewicz, Yoshiya Sakurai, P. S. Anderson
Publikováno v:
Journal of medicinal chemistry. 29(5)
Our initial paper discussed brain edema resulting from traumatic head injury and the need for specific and effective agents to treat the disorder and disclosed a novel approach for the discovery of a drug of this kind. The current study describes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f8f7365e7041f4855f4374b10d6e7d
https://pubmed.ncbi.nlm.nih.gov/3701792
https://pubmed.ncbi.nlm.nih.gov/3701792
Autor:
N. P. Gould, A. A. Deana, Ralph Hirschmann, Edward J. Cragoe, M. L. Torchiana, Adolph M. Pietruszkiewicz, William A. Bolhofer, John D. Prugh, Charles N. Habecker, Jacob M. Hoffman
Publikováno v:
Journal of medicinal chemistry. 26(4)
A series of aminoalkyl-substituted pyridylureas has been prepared and evaluated as inhibitors of gastric acid secretion. N,N-Dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea (8g) was the most potent example of the class. Compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923e6e2847e10af35f235aef4ec87028
https://pubmed.ncbi.nlm.nih.gov/6834386
https://pubmed.ncbi.nlm.nih.gov/6834386
Autor:
Charles N. Habecker, William A. Bolhofer, M. L. Torchiana, Jacob M. Hoffman, Ralph Hirschmann, Adolph M. Pietruszkiewicz, Edward J. Cragoe
Publikováno v:
Journal of medicinal chemistry. 26(11)
The use of isotopic substitution to retard the oxidative metabolism of the gastric antisecretory agent N,N-dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea (1) and improve its antisecretory potency was examined. The pyridine ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd721a3435bed799c93e13e4e157c7ba
https://pubmed.ncbi.nlm.nih.gov/6631919
https://pubmed.ncbi.nlm.nih.gov/6631919
Autor:
John J. Baldwin, Jacob M. Hoffman, Adolph M. Pietruszkiewicz, William C. Lumma, William A. Bolhofer
Publikováno v:
Chemischer Informationsdienst. 15
Two methods have been developed for the synthesis of 3-amino-1,2,5-thiadiazole 1,1-dioxides; one leads to 4-alkyl derivatives, the other to 4-aryl analogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68aa085f01c84d5f24c34eff31d69bbc
https://doi.org/10.1002/chin.198403217
https://doi.org/10.1002/chin.198403217